Navigation Links
Gamma Secretase Modulators Show Promise in Alzheimer's Disease Animal Model Efficacy Studies, According to Research Conducted by TorreyPines Therapeutics
Date:3/31/2008

tes that individuals genetically predisposed to early-onset forms of Alzheimer's disease make a greater proportion of the longer Ab peptides, especially Ab42, relative to unaffected individuals. All of these Ab peptides, including the pathogenic Ab42 peptide, are derived via proteolysis from a much larger precursor molecule known as the amyloid b precursor protein (APP).

During normal catabolism, two crucial enzymes, or proteases, are responsible for generating these Ab peptides from APP. The first enzyme, beta secretase (b-secretase), cuts the APP molecule into two major pieces comprised of a soluble extracellular fragment and a membrane-associated fragment. The second enzyme, gamma secretase (g-secretase), then cleaves the membrane- associated fragment into one of several different Ab peptides that vary in length from 34 to 42 amino acids.

About TorreyPines Therapeutics

TorreyPines Therapeutics, Inc. is a biopharmaceutical company committed to providing patients with better alternatives to existing therapies through the research, development and commercialization of small molecule compounds. The company's goal is to develop versatile product candidates each capable of treating a number of acute and chronic diseases and disorders such as migraine, chronic pain, muscle spasticity and rigidity, xerostomia and cognitive disorders. The company is currently developing four product candidates, two ionotropic glutamate receptor antagonists and two muscarinic receptor agonists. Further information is available at http://www.torreypinestherapeutics.com.

This press release contains forward-looking statements or predictions. Such forward-looking statements include, but are not limited to, statements regarding the potential for GSMs as a treatment for Alzheimer's disease. Such statements are subject to numerous known and unknown risks, uncertainties and other factors, which may cause
'/>"/>

SOURCE TorreyPines Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Study Determines Breast-Specific Gamma Imaging Has Higher Specificity Than MRI in Patients With Equivocal Mammograms
2. Breast-Specific Gamma Imaging (BSGI) Changes Patient Care Management
3. Breast Cancer Imaging Study Indicates Breast-Specific Gamma Imaging (BSGI) Is a Strong Adjunct Imaging Modality to Mammography and Ultrasound
4. Moving beyond tamoxifen: Drug discovery and the future of selective hormone receptor modulators
5. New study shows promise in reducing surgical risks associated with surgical bleeding
6. New Heart Pump Shows Promise in Trial
7. Blood-flow detector software show promise in preventing brain damage
8. The 7 Key Questions About the Schwarzenegger/Nunez Health Care Compromise
9. Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
10. Genetics Hold Promise, Challenges for Cancer Care
11. New way to diagnose Alzheimers disease promises earlier treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... August 29, 2014 Senior Independence ... operations & business development. , Rees has been with ... of business development. , A wholly owned subsidiary of ... provides older adults with options, including personalized home health ... (e.g., meal preparation) and therapeutic adult day centers. , ...
(Date:8/29/2014)... 29, 2014 Los Angeles dental ... mini implants to area patients. With this treatment, patients ... long-term teeth shifting and loss of appearance. Although mini ... implants , their smaller size allows for less ... easier recovery. Once placed, mini implants can be topped ...
(Date:8/29/2014)... A home should be a safe haven, but there ... Amica Insurance is sharing some tips to help improve safety in ... following safety measures: , Kitchen, , Store hazardous ... and keep them away from food. , ... , Bathroom , Put slip-resistant ...
(Date:8/29/2014)... life support (BLS) videos available on YouTube provide ... according to a new study published in ... Australasian College for Emergency Medicine (ACEM). , ... are known to improve survival for,victims. , A ... the study, which reviewed educational videos from the ...
(Date:8/29/2014)... Saturday 30 August 2014: New ESC registries ... coronary syndromes (ACS). The announcement comes as the ... and the study on heart failure patients conducted ... and Development (OECD) begins an outcomes evaluation. , ... EURObservational Research Programme (EORP). , Professor Roberto Ferrari, ...
Breaking Medicine News(10 mins):Health News:Senior Independence Promotes Rees to Vice President of Operations & Business Development 2Health News:Dental Implants Dentist, Kevin Sands DDS, Is Now Offering Mini Implants 2Health News:Improve Home Safety with Tips from Amica Insurance 2Health News:New ESC registries launched on cardiac oncology and ACS 2Health News:New ESC registries launched on cardiac oncology and ACS 3Health News:New ESC registries launched on cardiac oncology and ACS 4
... ... of software & technology to Home Medical Equipment, Durable Medical Equipment, Respiratory ... a solution for each individual segment of Home Care as well as ... provider offering several or all of these product/service lines within one integrated ...
... ... interactive database on tap water quality. The data has been compiled from state environment ... concerning the database. , ... Washington (Vocus) December 11, 2009 -- On December 12, 2009, the Environmental Working ...
... 11 They feature real patients, real stories and ... campaign titled "Real Patients, Real Stories" won Platinum in ... event held in Chicago this fall. , Baylor teamed ... the non-traditional spots. The documentary-style ads feature actual patients ...
... sensory problems before onset of complex disease symptoms benefits ... -- Identifying sight and hearing problems in teens who ... doctors fully restore those senses and lessen the impact ... A new study found that problems in basic sensory ...
... A gene commonly studied by cancer researchers has been linked ... Understanding how the gene works means scientists may be ... a study by Texas AgriLife Research appearing in the Journal ... understand the mechanism, or how the gene works, we believe a ...
... The Visiting Nurse Association (VNA) of Greater Philadelphia is ... who reside in lower Bucks County. , The ... wound and ostomy care, and chronic care services. Nurses, ... to patients in their homes. , VNA also ...
Cached Medicine News:Health News:Fastrack Announces Enhancements to the Enterprise System for Home Care 2Health News:Statement from American Water Works Association on the Environmental Working Group's report on Tap Water Quality Testing and Violations 2Health News:Baylor Health Care System's Patient Testimonial Ad Campaign Wins National Award 2Health News:Early Treatment of Hearing, Vision Helps in Schizophrenia 2Health News:Study shows how gene action may lead to diabetes prevention, cure 2Health News:The Visiting Nurse Association of Greater Philadelphia Expands Service to Bucks County 2
(Date:8/28/2014)... CHENGDU, China , Aug. 28, 2014 /PRNewswire/ ... TPI ), a pharmaceutical company that specializes ... branded generics and active pharmaceutical ingredients (API) today ... the Company,s Qionglai Facility (QLF). ... Manufacturing Practice (GMP) dataset for China Food & ...
(Date:8/28/2014)... SALT LAKE CITY , Aug. 28, 2014 /PRNewswire-iReach/ ... in 2000 by service academy graduates, has published a ... its concentrated, three-day Leadership Excellence Course . In ... the  Leadership Excellence Course to Albuquerque , ... Tucson . Photo - http://photos.prnewswire.com/prnh/20140828/140814 ...
(Date:8/28/2014)... Aug. 28, 2014 Nonin Medical, Inc., the ... noninvasive medical monitoring, today announced that the Food and ... OEM/eHealth finger pulse oximeter for use in ... plugs into a telemedicine hub or kiosk through a ... in pediatric to adult patients. The Model 3231 received ...
Breaking Medicine Technology:TPI Submits Dataset for GMP Inspection at Qionglai Facility (QLF) 2Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 2Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 3Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 4Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 5Nonin Medical Announces FDA Clearance of Nonin Model 3231 USB Pulse Oximeter 2
... N.J., May 03, 2007 /PRNewswire-FirstCall/ --,Alpharma ... pharmaceutical company,through its Pharmaceuticals Division, this ... study of its investigational,abuse-deterrent, extended-release opioid ... the American Pain Society in Washington, ...
... /PRNewswire-FirstCall/ --,Genelabs Technologies, Inc. announced today that ... International Conference on Antiviral,Research being held in ... virus (HCV) polymerase inhibitor,discovered by Genelabs. , ... D. Roberts,Ph.D., Director of Medicinal Chemistry at ...
Cached Medicine Technology:Alpharma Presents Positive Pharmacokinetic Study Results of Its,Investigational Abuse-Deterrent, Extended-Release Opioid 2Alpharma Presents Positive Pharmacokinetic Study Results of Its,Investigational Abuse-Deterrent, Extended-Release Opioid 3Alpharma Presents Positive Pharmacokinetic Study Results of Its,Investigational Abuse-Deterrent, Extended-Release Opioid 4Genelabs Technologies Announces Presentation of Data on,Non-Nucleoside HCV Polymerase Inhibitor at 20th International,Conference on Antiviral Research Meeting 2Genelabs Technologies Announces Presentation of Data on,Non-Nucleoside HCV Polymerase Inhibitor at 20th International,Conference on Antiviral Research Meeting 3
Inquire...
Flextend is a hydrocolloid skin barrier that is designed to be the most resistant to discharge and is the barrier of choice for urostomies and high output ileosotomies....
Premier pouches provide the ultimate in skin protection with our long wearing Flextend skin barriers and superior comfort with our soft and silky ComfortWear panels....
... APTT-based kit for the screening of factor-V-related ... of the test for the factor V:Q506 ... plasma with an excess of V-DEF Plasma ... to discriminate between heterozygous and homozygous factor ...
Medicine Products: