Navigation Links
Gamma Secretase Modulators Show Promise in Alzheimer's Disease Animal Model Efficacy Studies, According to Research Conducted by TorreyPines Therapeutics
Date:3/31/2008

LA JOLLA, Calif., March 31 /PRNewswire/ -- Gamma secretase modulators (GSMs) have shown promise in Alzheimer's disease animal model efficacy studies, according to research conducted by TorreyPines Therapeutics, Inc. (Nasdaq: TPTX).

Presented by Steven Wagner, Ph.D., the company's Chief Scientific Officer, at the recent Keystone Symposium on Alzheimer's Disease, data demonstrated that GSMs provide a more selective mechanism than gamma secretase inhibitors (GSIs). The in vivo research involved internally discovered and optimized compounds that modulate the g-secretase complex without inhibiting its catalytic activity. These GSMs appear to reduce the formation of the longer pathogenic Ab peptides (e.g, Ab42) and allow the g-secretase enzyme complex to generate the shorter, less fibrillogenic Ab peptides such as Ab38 and Ab37 and to perform its other necessary functions.

"We have identified a series of GSM compounds that are intended to modulate the enzyme's activity without preventing it from performing its normal functions," said Dr. Wagner. "These orally bio-available, small molecule GSMs appear to have addressed some of the pitfalls associated with the GSI compounds, which have been associated with side effects. The significance of our findings is that we may be able to selectively attenuate the pathological functions of this enzyme complex without affecting the other critical physiological functions it performs."

The major pathological hallmark of Alzheimer's disease is the abundance of deposits called neuritic plaques in key areas of the brain that control memory and cognition. These neuritic plaques are largely comprised of aggregations of fibrillar peptides referred to as amyloid b, or Ab peptides. Evidence indica
'/>"/>

SOURCE TorreyPines Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Study Determines Breast-Specific Gamma Imaging Has Higher Specificity Than MRI in Patients With Equivocal Mammograms
2. Breast-Specific Gamma Imaging (BSGI) Changes Patient Care Management
3. Breast Cancer Imaging Study Indicates Breast-Specific Gamma Imaging (BSGI) Is a Strong Adjunct Imaging Modality to Mammography and Ultrasound
4. Moving beyond tamoxifen: Drug discovery and the future of selective hormone receptor modulators
5. New study shows promise in reducing surgical risks associated with surgical bleeding
6. New Heart Pump Shows Promise in Trial
7. Blood-flow detector software show promise in preventing brain damage
8. The 7 Key Questions About the Schwarzenegger/Nunez Health Care Compromise
9. Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
10. Genetics Hold Promise, Challenges for Cancer Care
11. New way to diagnose Alzheimers disease promises earlier treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... It’s a pattern that won’t relent anytime ... on this planet, cyber scammers will immediately be thinking ... their own personal gain. And on April 30, ... issued an alert titled “Nepal Earthquake Disaster Email Scams,” ... earthquake in Nepal. The scam emails may contain links ...
(Date:5/2/2015)... “ Peachtree Audio ” was featured on NewsWatch ... the latest and coolest technology products available to consumers. ... NewsWatch, conducted the review and shared with viewers how ... is an important part of people’s lives – and ... royal treatment. Peachtree Audio does just that with high-end ...
(Date:5/2/2015)... 2015 Kare Visits LLC. launched in Chicago ... caregivers. Kare Visits offers relief for caregivers by visiting ... According to the Caregiver Action Network, eight in ... 20 hours a week caring for an elderly or disabled ... hire a nurse, a caregiver is now empowered to schedule ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 ZoomCare, the ... has submitted plans to offer its new healthcare insurance ... The ZOOM+ Personal Health Insurance System is the nation’s ... to enhance human performance. ZOOM+ Personal Health Insurance was ... delivery system that are subject to review and regulation ...
(Date:5/1/2015)... 2015 IDLife LLC, a health and ... announce the addition of its newest partner and fitness ... long athlete, growing up in gymnastics and competitive diving, ... becoming a personal trainer and helping others achieve their ... several TV shows highlighting her stunning physique and unique ...
Breaking Medicine News(10 mins):Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:ZoomCare Applies to be on Oregon Exchange 2Health News:IDLife LLC Announces New Partnership with Fitness Celebrity, Jen Widerstrom 2
... NEW YORK, Jan. 7 Crystal Research Associates, ... Informational Overview(R),(EIO(R)) on Unilife Medical Solutions Limited (UNI-ASX). ... www.crystalra.com and www.unilife.com . , ... or "the Company") develops,and supplies innovative safety medical ...
... can be healthy and hazardous for seniors, experts ... head south each winter to escape the cold often feel ... are adjustments to be made to make sure these "snowbirds" ... more time socializing, boosts mood and well being for 65-plus ...
... Jan. 7 AGA Medical Corporation ("AGA,Medical") announced ... Ministry,of Health, Labour and Welfare (MHLW) for its ... transcatheter occlusion device used for the,non-surgical closure of ... heart defect that occurs when a blood vessel ...
... Jan. 7 Pearson VUE, the computer-based testing ... signed an agreement with the National Association of ... test delivery provider of the computer-based Foreign Pharmacy ... these exams will be delivered throughout the secure ...
... FL, Jan. 7 /PRNewswire-FirstCall/ - Hard to Treat Diseases ... announce that it has identified a cosmetics company as ... in E Europe (Serbia) is engaged in online sales ... skin and lip balm. It has a wide variety ...
... REDWOOD CITY, Calif., Jan. 7 Ingenuity Systems, ... researchers, today,announced the release of IPA 7 with ... of a series of powerful biological filters and ... experimental results and fine-,tune scientific hypotheses in relation ...
Cached Medicine News:Health News:Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Unilife Medical Solutions Limited 2Health News:Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Unilife Medical Solutions Limited 3Health News:'Snowbirds' Beware the Climate Changes 2Health News:'Snowbirds' Beware the Climate Changes 3Health News:AGA Medical Receives Japanese Approval for AMPLATZER(R) Duct Occluder 2Health News:AGA Medical Receives Japanese Approval for AMPLATZER(R) Duct Occluder 3Health News:NABP Expanding Computer-Based Test Delivery to Include Foreign Pharmacy Graduate Equivalency Examination(R) 2Health News:Hard To Treat Diseases (HTDS) Set To Acquire Cosmetics Company 2Health News:IPA 7 Introduces Unique Contextual Search and Analysis Capabilities 2
(Date:5/1/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/vzcw2v/americas_clinical ) has ... Market by Product, by End-Users - Forecast to 2019" ... Analyzers market is estimated to grow at a CAGR of ... Canada , Mexico , ... are covered in this report. The Americas is ...
(Date:5/1/2015)... -- Portal Instruments, Inc., an emerging leader in the development ... Robert Langer, Sc. D., MIT Institute Professor, and ... have joined the company,s Scientific Advisory Board. ... Professor Robert Langer and Professor Peter ... Anquetil , Chief Executive Officer of Portal Instruments. "We ...
(Date:5/1/2015)... May 1, 2015  CytRx Corporation (CYTR), a ... today reported financial results for the three months ... of recent accomplishments and upcoming milestones for its ... milestones in the early months of 2015, including ... trial of aldoxorubicin in patients with soft tissue ...
Breaking Medicine Technology:Americas Clinical Chemistry Analyzer (Semi-Automated Clinical Chemistry and Fully-Automated Clinical Chemistry) Market - Forecast to 2019 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 3Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 4CytRx Reports First Quarter 2015 Financial Results 2CytRx Reports First Quarter 2015 Financial Results 3CytRx Reports First Quarter 2015 Financial Results 4CytRx Reports First Quarter 2015 Financial Results 5CytRx Reports First Quarter 2015 Financial Results 6CytRx Reports First Quarter 2015 Financial Results 7CytRx Reports First Quarter 2015 Financial Results 8CytRx Reports First Quarter 2015 Financial Results 9CytRx Reports First Quarter 2015 Financial Results 10CytRx Reports First Quarter 2015 Financial Results 11
... 17, 2012  PLC Systems Inc. (OTC: PLCSF), a company ... an article summarizing the results from its U.S. pilot ... December 26, 2011 International Journal of Cardiology , ... Adult Congenital Heart Disease. The results from this ...
...  Palatin Technologies, Inc. (NYSE Amex: PTN ) ... $1.1 million of non-dilutive funding through the New Jersey ... sold both New Jersey net operating losses and research ... Last year, Palatin Technologies received approximately $637,000 under this ...
Cached Medicine Technology:Results From Pilot Trial of PLC's RenalGuard® Published in International Journal of Cardiology 2Results From Pilot Trial of PLC's RenalGuard® Published in International Journal of Cardiology 3
... Card, three HRR symbol cards and instructions. Kit ... subsequent HRR 4th Edition color testing. There are ... youngest patients, the parents can borrow the kit ... matching and become familiar with the HRR symbols. ...
Magnetic Farnsworth D15 kit. Magnets move the color disks. Protects disks from fingerprints. Keeps all the disks in one place. Clear glass insures accurate color perception. Makes color testing fun....
... pseudoisochromatic test from Richmond Products includes the four ... 14 diagnostic series for a total of 24 ... tab for easy and clean page selection. The ... English and a laminated copy of the score ...
Ishihara 14 plate color vision testing set. Suitable for screening purposes....
Medicine Products: