Navigation Links
Game changer: Biomarker identified for noncancerous pancreatic cysts
Date:2/11/2014

INDIANAPOLIS -- Researchers at the Indiana University School of Medicine have discovered a highly accurate, noninvasive test to identify benign pancreatic cysts, which could spare patients years of nerve-racking trips to the doctor or potentially dangerous surgery.

The findings are reported in "Vascular Endothelial Growth Factor, a Novel and Highly Accurate Pancreatic Fluid Biomarker for Serous Pancreatic Cysts" online in the Journal of the American College of Surgeons.

The test, which analyzes fluid from pancreatic cysts, can identify a common type of benign cyst that can't be differentiated by imaging alone from cysts that may progress to pancreatic cancer.

Pancreatic cyst fluid is tested for a biomarker, a specific isoform of vascular endothelial growth factor A, or VEGF-A. Pancreatic cyst fluid is often obtained in patients with pancreatic cysts as a part of standard testing during endoscopy. High levels of VEGF-A indicate with 99 percent accuracy that the cyst will not become malignant, the researchers found after analyzing the results of 87 patients.

First author Michele T. Yip-Schneider, Ph.D., associate research professor of surgery, and senior author C. Max Schmidt, M.D., Ph.D., MBA, professor of surgery, biochemistry and molecular biology, report this is the first cyst fluid protein biomarker that can differentiate serous cystic neoplasms, a benign type of cystic lesion, from all other cancerous or precancerous cystic lesions without surgery.

Pancreatic cancer is one of the deadliest cancers in part because it is frequently diagnosed late and treatment options are somewhat limited. According to the National Cancer Institute, about 45,220 people will be diagnosed this year with pancreatic cancer and about 38,460 will die from the disease.

Treatments may include chemotherapy, radiation and surgery, but few patients are cured.

"Only 15 percent of pancreatic cancer patients will benefit from surgery, and of those, only about 20 percent will survive five years," said Dr. Schmidt, who is a researcher with the Indiana University Melvin and Bren Simon Cancer Center and director of the IU Health Pancreatic Cyst and Cancer Early Detection Center.

Complications from pancreatic surgery are common and can be life threatening, so sparing a patient unnecessary surgery is important, Dr. Schmidt said.

"As scientists, we have tried to figure out which cystic lesions are benign, which are pre-cancerous and which are malignant," Dr. Yip-Schneider said. "Although pancreatic cysts are best seen on pancreatic MRI-MRCP, making a diagnosis of which type of cyst and how likely cancer will develop is not usually possible through imaging alone."

Surgery is not the panacea that patients frequently hope for, and the majority of pancreatic cancer patients aren't even eligible due to the advanced stage of the disease at presentation.

Pancreatic cysts and cancer are becoming more common in the American population. It is unclear why, but pancreatic cancer is clearly associated with obesity, smoking and a family history of pancreatic cancer.

Today, about 3 percent of the U.S. population has pancreatic cysts, although many are asymptomatic and go undiagnosed. Most of these cysts are pre-cancerous, but some are completely benign while others are cancerous. Patients go through extensive follow-up medical visits, invasive biopsies and sometimes unnecessary surgery to determine the true nature of their pancreatic cyst. The novel marker VEGF-A can completely eliminate the need for this extensive follow-up and potential harm for patients with unrecognized benign cysts, the researchers said.

"Many of my patients when initially told they have pancreatic cysts are very fearful and ask for surgical removal of the cyst or the entire pancreas before they even learn their options," Dr. Schmidt said. "Now, physicians will have an outpatient procedure to offer that can take some of the guesswork out of the equation."


'/>"/>

Contact: Mary Hardin
mhardin@iu.edu
317-274-5456
Indiana University
Source:Eurekalert  

Related medicine news :

1. SomaLogic publishes proteomic biomarker analysis of lung cancer tissue samples
2. Biomarkers can reveal IBS
3. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
4. Early biomarker for pancreatic cancer identified
5. New biomarker test predicts arthritis at much earlier stage, MU researchers say
6. Biomarker predicts response to cancer treatment
7. Novel biomarkers reveal evidence of radiation exposure
8. GW researchers discover biomarker for advanced bile duct fibrosis and bile duct cancer
9. Using biomarkers to identify and treat schizophrenia
10. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
11. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Game changer: Biomarker identified for noncancerous pancreatic cysts
(Date:6/28/2017)... ... June 28, 2017 , ... Drs. Steven Crandall, Karen Johnson and Kathy Lopez ... and Upper St. Clair, PA, without a referral. The doctors address jaw pain ... the temporomandibular joint and facial muscles that support it. , Jaw pain can ...
(Date:6/28/2017)... IL (PRWEB) , ... June 28, 2017 , ... Eating ... shows that every 62 minutes, at least one person dies as a direct result ... a greater need exists for qualified treatment providers. The iaedp Foundation meets this challenge ...
(Date:6/28/2017)... ... , ... Park Systems , a leader in Atomic Force Microscopy (AFM) ... and Park customers on July 11, 2017 from 12-2pm at the Thirsty Bear Brewing ... of Park Systems, and Prof. Krishna Saraswat , Rickey/Nielsen Professor in the School ...
(Date:6/28/2017)... ... June 28, 2017 , ... ... financial consultations to communities in northern Virginia and DC, is announcing a cooperative ... for patients with Alzheimer’s and other disorders that lead to memory impairment. , ...
(Date:6/27/2017)... ... June 27, 2017 , ... DrugDev understands that for many ... trust the sponsor to pay them correctly and on time. As the search for ... strategies that encourage sites to work on their studies. , At a complimentary live ...
Breaking Medicine News(10 mins):
(Date:6/19/2017)... -- Researchers from DRUGSCAN ® and INC Research ® ... complimentary webinar titled, "Untangling methods to tamper with opioid ... on Wednesday June 28, 2017 from 12:00 PM to ... feature interviews with recreational and dependent prescription opioid abusers ... use to prepare opioid tablets for routes of administration ...
(Date:6/14/2017)... June 14, 2017  In 2016, Embodied Labs ... pitch competition and came away with $25,000 in ... described by Forbes as "entering the life of another" ... as teaching "empathy to medical professionals in an entirely ... recently named a finalist for the Department of Education,s ...
(Date:6/9/2017)... PALO ALTO, Calif. , June 9, 2017 /PRNewswire/ ... medical device company focused on the design, manufacture, sale ... updated the market on the progress of its commercial ... AeroForm is now available in more than one hundred ... country. AeroForm offers a needle-free alternative ...
Breaking Medicine Technology: