Navigation Links
Gallo Center study in mice links cocaine use to new brain structures
Date:8/25/2013

Mice given cocaine showed rapid growth in new brain structures associated with learning and memory, according to a research team from the Ernest Gallo Clinic and Research Center at UC San Francisco. The findings suggest a way in which drug use may lead to drug-seeking behavior that fosters continued drug use, according to the scientists.

The researchers used a microscope that allowed them to peer directly into nerve cells within the brains of living mice, and within two hours of giving a drug they found significant increases in the density of dendritic spines structures that bear synapses required for signaling in the animals' frontal cortex. In contrast, mice given saline solution showed no such increase.

The researchers also found a relationship between the growth of new dendritic spines and drug-associated learning. Specifically, mice that grew the most new spines were those that developed the strongest preference for being in the enclosure where they received cocaine rather than in the enclosure where they received saline. The team published its findings online in Nature Neuroscience on August 25, 2013.

"This gives us a possible mechanism for how drug use fuels further drug-seeking behavior," said principal investigator Linda Wilbrecht, PhD, a Gallo investigator now at UC Berkeley, but who led the research while she was on the UCSF faculty.

"It's been observed that long-term drug users show decreased function in the frontal cortex in connection with mundane cues or tasks, and increased function in response to drug-related activity or information," Wilbrecht said. "This research suggests how the brains of drug users might shift toward those drug-related associations."

In all living brains there is a baseline level of creation of new spines in response to, or in anticipation of, day-to-day learning, Wilbrecht said. By enhancing this growth, cocaine might be a super-learning stimulus that reinforces learnin
'/>"/>

Contact: Jeffrey Norris
jeff.norris@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A Milestone: Pool Services Technologies Just Conserved 7.5 Million Gallons of Water in San Diego
2. Does gallows humor among physicians encourage accusations of murder and euthanasia?
3. Increasing dopamine in brains frontal cortex decreases impulsive tendency, UCSF-Gallo study finds
4. Increasing dopamine in frontal cortex decreases impulsive tendency, UCSF-Gallo scientists find
5. Gallo Research Center to lead $15 million US Army-funded national research program
6. Physicians' Hair Restoration Center Unveils Latest Techniques for Solving Hair Loss
7. DuPage Health and Wellness Center of Glen Ellyn, IL Celebrates 15 Years of Service to the Greater Chicago Community and an Important Clinical Milestone
8. San Bernardino County Sheriff Deputy Alex Collins Recognizes Medical Staff from Loma Linda University Medical Center
9. HealthLine Systems' Celebrates 27 Years of Innovation for Healthcare Contact Centers
10. CommuniCare Health Centers Expanding Across San Antonio
11. Software Defined Data Center (SDDC) Market to Reach $5.41 Billion by 2018 at a 68.7% CAGR - New Report by MarketsandMarkets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... PA (PRWEB) July 12, 2014 "The second ... it’s uncomfortable and painful to wear shoes," said an inventor ... special sock that prevents this from happening. , He then ... effective way to prevent the second and big toes from ... endurance while wearing shoes. Ergonomic and easy to use, it's ...
(Date:7/12/2014)... 2014 As DePuy Pinnacle hip lawsuits ... courts, Bernstein Liebhard LLP notes the publication of a ... the failure of metal-on-metal hip replacements. The research, which ... of Bone & Joint Surgery, looked at 597 ... prostheses at least twelve months earlier. The blood metal ...
(Date:7/12/2014)... “Critical Care Therapeutics in Major Developed ... PCCs and Recombinant Products to Drive Market,” which ... in the US, UK, France, Germany, Italy, Spain, ... of market size for 2013, along with market ... that are being treated using the five major ...
(Date:7/12/2014)... Arab Emirates (PRWEB) July 12, 2014 ... Los Angeles basketball legend is heading to the UAE. ... and six-time champion will be in the UAE from ... Fitness Weekend in support of diabetes awareness. The event ... award-winning entertainment marketing and event management company based in ...
(Date:7/12/2014)... Seattle, Wa (PRWEB) July 12, 2014 ... by Doctors Sen and Samantha Pearson, a couple boasting ... chose to launch Restore My Vision Today as a ... that many ophthalmologists have become in their respective ... makes readers privy to a “secret” trove of pertinent ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3
... 2011) -Texas Children,s Hospital in Houston announces that ... earned a National Science Foundation Early Career Development (CAREER) ... congenital heart disease, heart defects, and the development of ... amniotic fluid. The award comes with new funding of ...
... brain function variations between the left and right sides ... weight of the placenta. The finding could shed new ... later life. The research, conducted at the University ... Epidemiology Unit at Southampton General Hospital, reveals that children ...
... Spanish . Between 5 % and 10 % of ... father or mother a mutation in a gene that is susceptible to ... of the genes to be monitored. It is estimated that 30 % ... these two genes (which suggests, at the same time, that there are ...
... the University of the Basque Country (UPV/EHU) has carried ... between the sexes and generations in terms of forgiveness. ... while women are better at forgiving than men. ... it shows us what reasons people have for forgiving ...
... both type 1 diabetes and CKD have an increased ... with type 1 diabetes and overt nephropathy develop End-Stage ... The competing risks of death and ESRD may confound ... Now, the researchers at the University of Helsinki, University ...
... Reporter , THURSDAY, Feb. 17 (HealthDay News) -- Cyclists ... street traffic have fewer accidents compared to bikers pedalling ... found that there is a 28 percent lower injury ... in parallel and comparable roads," noted study lead author ...
Cached Medicine News:Health News:Tissue engineering methods earn funding to heal little hearts 2Health News:Brain function linked to birth size in groundbreaking new study 2Health News:Ph.D. thesis on 2 genes involved in hereditary breast and ovary cancer cases 2Health News:Women are better at forgiving 2Health News:Competing risks analysis highlights new targets in preventing ESRD and death of diabetics 2Health News:Separate Bikes-Only Lanes in Cities Cut Injury Rate: Study 2Health News:Separate Bikes-Only Lanes in Cities Cut Injury Rate: Study 3
(Date:7/10/2014)... July 11, 2014  Major advances in radiation ... are being highlighted in a three-day Oncology Summit ... from 10-12 July, 2014.  Renowned national and international cancer experts ... practices and exchange knowledge on modern technologies making ... efficient. The Summit will address ...
(Date:7/10/2014)... 10, 2014 Integrated Silicon Solution, Inc. (Nasdaq: ... and analog IC solutions, today announced that it will ... 2014, at 7:00 a.m. Pacific Time (10:00 a.m. Eastern ... fiscal 2014 third quarter ended June 30, 2014. ... 1-888-556-4997 before 6:50 a.m. Pacific time on July 24, ...
(Date:7/10/2014)... July 10, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... it has completed the sale to Galderma of all ... or held by Valeant for $1.4 billion in cash, ... which recently completed its acquisition of Galderma. ... our products to a company that is firmly committed ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5
Iems Incubator/Shaker expansion module for 2 module incubator/shaker. high performance microplate incubator and orbital shaker. It's superior temperature control and efficient orbital shaking reduce ...
... are designed to give reliable performance for all ... on/off button, power supply socket and fuse holder ... unit. The speed knob is located on the ... from a minimum 950 rpm to a maximum ...
The BD LSR II can be configured with up to four fixed alignment lasers and the ability to detect up to 15 colors, utilizing a revolutionary optical design. The BD LSR II can be configured with a 488 ...
... especially suited for cell analysis and ... allows to analyze scatter signals in ... channels. Data acquisition, analysis, and real-time ... PC employing Partec DPAC software, built-in ...
Medicine Products: