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Galenea and Organix Announce Exclusive License Agreement for 5-HT2C Agonists for the Treatment of Obesity
Date:10/28/2008

CAMBRIDGE and WOBURN, Mass., Oct. 28 /PRNewswire/ -- Galenea Corp. today announced the signing of an agreement with Organix, Inc. and its academic collaborators that gives Galenea a license to 5-HT2C agonists for the treatment of obesity and other related disorders. The license grants Galenea the exclusive worldwide rights to develop, manufacture and commercialize the novel indole-based agonists.

The licensed compounds have demonstrated potent 5-HT2C receptor agonist activity, highly desirable selectivity against other serotonin receptor family members and significant reduction of food intake in animal models of obesity. Based on these characteristics, the companies are aiming to generate a best-in-class molecule for the safe and effective treatment of obesity.

Organix, a Woburn, MA based company that conducts organic chemistry research and development under contract, has been collaborating with researchers at the University of North Carolina at Chapel Hill and Tufts University School of Medicine in Boston. Under the auspices of Small Business Innovation Research (SBIR) grants from the National Institutes of Health, Howard P. Sard, PhD of Organix has designed and synthesized a novel class of molecules targeted toward the 5-HT2C receptor. A recognized leader in the field of brain and psychiatric disorders, Bryan L. Roth, MD, PhD, formerly of Case Western Reserve University and now Professor of Pharmacology at UNC and Director of the NIMH Psychoactive Drug Screening Program, has been responsible for the in vitro testing of the molecules. Louis Shuster, PhD, Professor Emeritus in the Department of Pharmacology and Experimental Therapeutics at Tufts, led the Tufts scientific team that was responsible for the generation of pharmacology data and the demonstration of efficacy in in vivo models of obesity.

"This program is the result of a productive collaboration between our chemists and the biologists at UNC and Tufts and we look forward to Gale
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SOURCE Galenea Corp.
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