Navigation Links
Gains made towards treatment of rare bone disease
Date:2/20/2013

This press release is available in French.

Diagnosed in toddlers, X-linked hypophosphatemia (XLH) is the most common form of heritable rickets, in which soft bones bend and deform, and tooth abscesses develop because infections penetrate soft teeth that are not properly calcified. Researchers at McGill University and the Federal University of Sao Paulo have identified that osteopontin, a major bone and tooth substrate protein, plays a role in XLH. Their discovery may pave the way to effectively treating this rare disease.

The findings were made by the laboratories of Marc McKee, a professor in the Faculty of Dentistry and the Department of Anatomy and Cell Biology at McGill University, and of Nilana M.T. Barros, a professor at the Federal University of Sao Paulo. The team built upon previous research that had shown that mutations in the single gene PHEX are responsible for causing XLH. The results of this latest research by Drs. McKee and Barros will be published in the March issue of the Journal of Bone and Mineral Research.

"XLH is caused in part by renal phosphate wasting, which is the urinary loss from the body of phosphate, an important building block of bones and teeth, along with calcium." says Prof. McKee. "In pursuing other factors that might contribute to XLH, we used a variety of research methods to show that PHEX enzymatic activity leads to an essentially complete degradation of osteopontin in bones."

This loss of osteopontin, a known potent inhibitor of mineralization (or calcification) in the skeleton and dentition, normally allows bones and teeth to mineralize and thus harden to meet the biomechanical demands placed on them. In XLH patients lacking functional PHEX enzyme, osteopontin and some of its smaller potent inhibitory peptides are retained and accumulate within the bone. This prevents their hardeni
'/>"/>

Contact: Cynthia Lee
cynthia.lee@mcgill.ca
514-398-6754
McGill University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists identify major source of cells defense against oxidative stress
2. Omega-3 Supplements No Help Against Repeat Heart Trouble: Review
3. Kinase test may yield big gains for drug-resistant cancers
4. Will women use microbicides to protect themselves against HIV?
5. Vitamin E in diet protects against many cancers
6. Lower-Dose Radioiodine Effective Against Thyroid Cancer
7. Study identifies possible protective blood factors against Type 2 diabetes
8. New study of NIH funding allocations suggests potential efficiency gains
9. Stem Cell Study Shows Promising Results Against Heart Failure
10. Blood pressure drugs dont protect against colorectal cancer
11. CNIO scientists successfully test the first gene therapy against aging-associated decline
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Steven Reinberg HealthDay Reporter THURSDAY, ... increase slightly the risk of broken bones and injured joints, a ... found that among 7 percent of people who had an eczema ... joint injury and 0.6 percent had an injury that caused a ... with the skin condition had more than double the risk of ...
(Date:10/30/2014)... October 30, 2014—(BRONX, NY)—Investigators at Albert Einstein ... and Montefiore Medical Center will present their ... America,s (GSA) 67th Annual Scientific Meeting. Topics include ... survival, risk factors for cognitive impairment and the ... place November 5-9, 2014 in Washington, D.C., "Einstein-Montefiore ...
(Date:10/30/2014)... – You have to be at least 2 years ... younger babies, no official U.S. guidance exists other than ... mothers exclusively breastfeed for at least the first six ... , That,s the question that motivated researchers at ... Sciences to study the eating patterns of American infants ...
(Date:10/30/2014)... October 30, 2014 Nutrition Leaders, a ... weight loss aids, and more, is currently hosting a ... is already underway, is open to U.S. residents age ... December 15, 2014. One lucky winner will then be ... a $100 gift card to NutritionLeaders.com. , Nutrition Leaders’ ...
(Date:10/30/2014)... 30, 2014 Don Allred Insurance, a ... insurance plans for North Carolina residents, is excited to ... Burlington’s Holly Hill Mall. The new branch has been ... helping customers through all facets of the insurance selection ... Insurance spokesman Scott Allred couldn’t be happier with the ...
Breaking Medicine News(10 mins):Health News:Eczema Tied to Bone Fracture Risk in Study 2Health News:Einstein-Montefiore investigators present aging research at Gerontological Society of America's Annual Scientific Meeting 2Health News:Einstein-Montefiore investigators present aging research at Gerontological Society of America's Annual Scientific Meeting 3Health News:Einstein-Montefiore investigators present aging research at Gerontological Society of America's Annual Scientific Meeting 4Health News:What do American babies eat? A lot depends on Mom's socioeconomic background 2Health News:What do American babies eat? A lot depends on Mom's socioeconomic background 3Health News:Nutrition Leaders Announces Gift Card Sweepstakes 2Health News:Allred Insurance Satellite Office Grand Opening 2
... with Exciting New Line ... of Toys, ALPHARETTA, ... Bright Starts(TM) introduces its newest collection of,toys designed to delight babies with endless ... as he or,she explores a wide range of toys, from plush pals to ...
... ORANGE, N.J., July 8 The Henry H. ... people with,disabilities, announced today two key personnel changes ... A. DeLisa, M.D., current President of Kessler,Medical Rehabilitation ... while John DeLuca, Ph.D. will become the Vice ...
... Data, Structured Reporting, Scheduling and ... OAKLAND, Calif., July 8 The University of ... suite of IT,applications to equip their CV service lines ... to integrate disparate,systems, streamline workflow, improve quality, and help ...
... Improve Quality of Patient Data System, CAMBRIDGE, ... plc (LSE: AU. or AU.L), a global leader ... Servicio,Extremeno de Salud (SES), a provider of public ... Extremadura region of Spain, has selected,Autonomy,s Meaning-based Computing ...
... GRAS announces two new important features. A brand new version ... on-the-fly photometric analysis and report generation. The second item, is a ... imaging for themselves using the G13 telescope, located in Australia (more ... ...
... MedRetreat Offers 5 Steps to Help International Medical Providers Partner With Only ... ... 8, 2008 -- As interest in medical tourism heats up ... up to cash in on the emerging industry. But international hospitals should ...
Cached Medicine News:Health News:Bright Starts(TM) Adds New Twist to Old Favorites 2Health News:Bright Starts(TM) Adds New Twist to Old Favorites 3Health News:The Henry H. Kessler Foundation Appoints New Vice President for Research and Strengthens Relationship With Current Research Luminary 2Health News:Building a Fully Integrated Cardiovascular Imaging and Information System Webinar 2Health News:Spanish Health Service Provider Selects Autonomy to Deliver Innovation Within Healthcare 2Health News:Spanish Health Service Provider Selects Autonomy to Deliver Innovation Within Healthcare 3Health News:GRAS Proudly Announces Photometrica Version 2.0. Hailed as a Brilliant Solution for More Productive Astronomical Research by Those Engaged in Photometry Using the Global-Rent-a-scope Telescope Systems 2Health News:GRAS Proudly Announces Photometrica Version 2.0. Hailed as a Brilliant Solution for More Productive Astronomical Research by Those Engaged in Photometry Using the Global-Rent-a-scope Telescope Systems 3Health News:An American Appeal to Overseas Hospitals 2
(Date:10/30/2014)...   ViaDerma, Inc. (OTCQB: VDRM), a ... to market, has recently released a revolutionary new ... topical liquid tetracycline-based antibiotic that uses a patent-pending ... medication active ingredients into topical drugs. The drug ... to help prevent skin infection in minor cuts, ...
(Date:10/30/2014)... , Oct. 30, 2014  Nektar Therapeutics (Nasdaq: ... the third quarter ended September 30, 2014 on Thursday, ... markets. Howard Robin , president and chief executive ... results beginning at 5:00 p.m. Eastern Time (ET)/2:00 p.m. ... and a live audio-only Webcast of the conference call ...
(Date:10/30/2014)...   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and ... products for cells and tissues, today announced today ... be released on Thursday, November 6, 2014, and that ... webcast at 1:30 p.m. PST that afternoon. Management will ...
Breaking Medicine Technology:ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 3Nektar to Announce Financial Results for the Third Quarter 2014 on Thursday, November 6, 2014, After Close of U.S.-Based Financial Markets 2BioLife Solutions to Report Financial Results for Third Quarter 2014 and Provide Business Update on November 6, 2014 2
... Support Development,of Omega DUROS Continuous Delivery Therapy, ... Intarcia,Therapeutics, Inc., a privately held biopharmaceutical company,today ... study of omega,interferon with or without ribavirin ... C. The results demonstrate that,omega interferon in ...
... Conn., April 12, 2007 /PRNewswire-FirstCall/ --,CuraGen Corporation ... (PXD101), a histone deacetylase (HDAC) inhibitor being,investigated ... a protein,being investigated for the prevention of ... upcoming American Association for Cancer,Research (AACR) 2007 ...
Cached Medicine Technology:Intarcia Therapeutics Announces Final Results From a Phase 2 Study,of Injectable Omega Interferon plus Ribavirin for the Treatment of,Hepatitis C Genotype-1 2Intarcia Therapeutics Announces Final Results From a Phase 2 Study,of Injectable Omega Interferon plus Ribavirin for the Treatment of,Hepatitis C Genotype-1 3Intarcia Therapeutics Announces Final Results From a Phase 2 Study,of Injectable Omega Interferon plus Ribavirin for the Treatment of,Hepatitis C Genotype-1 4CuraGen Announces New Preclinical Results with Belinostat and,Velafermin to be Presented at AACR Annual Meeting 2CuraGen Announces New Preclinical Results with Belinostat and,Velafermin to be Presented at AACR Annual Meeting 3CuraGen Announces New Preclinical Results with Belinostat and,Velafermin to be Presented at AACR Annual Meeting 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: