Navigation Links
Gail Besner, MD, receives RO1 grant to continue research on necrotizing enterocolitis
Date:10/23/2011

Gail Besner, MD, principal investigator in the Center for Perinatal Research in The Research Institute at Nationwide Children's Hospital, has been awarded a 4-year RO1 grant from the National Institutes of Health to continue her work on heparin-binding EGF-like growth factor (HB-EGF) and intestinal ischemia-reperfusion injury.

Dr. Besner, who holds the John E. Fisher Endowed Chair in Neonatal Research and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine, initially discovered HB-EGF in laboratory experiments with human white blood cells, and it was later found to be a member of the epidermal growth factor family of growth factors. This family of growth factors is important in regulating development and maintenance of various tissues.

Dr. Besner's research examines the ability of HB-EGF to treat and prevent various forms of intestinal injury including neonatal necrotizing enterocolitis (NEC). Primarily seen in premature infants, NEC is the most common and most serious gastrointestinal disorder among hospitalized preterm infants. It is also their leading cause of surgical death.

Recent data suggest that HB-EGF may not only serve to treat NEC, but may also improve intestinal function afterward. Based on her laboratory discoveries, approval has been received from the U.S. Food and Drug Administration to begin using HB-EGF in human clinical trials.

"Dr. Besner has been conducting this outstanding research at Nationwide Children's Hospital for the last 20 years," said R. Lawrence Moss, MD, surgeon-in-chief at Nationwide Children's Hospital. "This would be an impressive accomplishment for any researcher. For an individual who also manages a large clinical practice and directs a fellowship training program, the achievements are monumental. Dr. Besner's discoveries will positively influence the lives of babies with NEC around the world."

In addition to her role as a researcher in the Center for Perinatal Research, Dr. Besner also serves as the Program Director of the Pediatric Surgery Residency Training Program and as the Associate Burn Director at Nationwide Children's. She is a member of the American College of Surgeons Executive Committee of the Surgical Research Committee, and recently completed a 4-year term as a full-time member of the Surgery, Anesthesia and Trauma Study Section of the National Institutes of Health. The long range goal of Dr. Besner's work is the use of HB-EGF in the prophylactic and therapeutic treatment of neonates at high risk of developing NEC in order to prevent and treat this often devastating disease.


'/>"/>
Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related medicine news :

1. BUSM receives $13.6m grant to develop tools for the early detection of lung cancer
2. Einstein College of Medicine receives $5.7 million for developmental disabilities research
3. BGU professor receives US National Distinguished International Science Award for substance abuse work
4. SUNY receives $4.3 million for research in neuroscience, pediatric pharmacology and vision
5. Case Western Reserve receives prestigious $5.4 million grant to study esophageal cancer
6. Penn receives $12.5 million from NIH to speed discovery to patient care
7. Autism Speaks Autism Treatment Network receives $12 million AIR-P grant
8. AMRI receives FDA notification on proposed corrective actions
9. Brigham and Womens Hospital researcher receives NIH Transformative Research Project Award
10. First US patient receives specially processed donor lungs at the University of Maryland
11. University of Kentucky Sanders-Brown Center on Aging receives $7 million from NIA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/17/2017)... ... 17, 2017 , ... While EHR data has revolutionized the ... innovative workstation designed to reduce nursing fatigue while enhancing productivity. Based on field ... a lightweight, highly mobile, multi-functional alternative to the limitations of handheld computing. , ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... Dr. Carol Francis' goals for each and every seminar, session and class ... will demonstrate five different brainwave tools which help energize creativity, focus mental functions, ...
(Date:2/17/2017)... ... February 17, 2017 , ... MAP Revenue Cycle Solutions (MAP ... has been promoted to Chief Executive Officer. , The need for maximizing ... shift that demands the transition from pay-for-service to pay-for-performance models. By delivering efficient ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... Top neuroendocrine ... International Healing NET Foundation Summit from February 21 - 23 in Beaver Creek, CO. ... (HNF). This marks the Summit’s second year in Beaver Creek, hosting over 60 faculty ...
(Date:2/16/2017)... ... February 17, 2017 , ... Teaching nursing care of vulnerable children ... development. ACE.P (pediatrics) is being created with the support of the Hearst Foundations. An ... , ACE.P will address what has been identified as a critical gap in preparing ...
Breaking Medicine News(10 mins):
(Date:2/18/2017)... WASHINGTON, N.Y. , Feb. 17, 2017 /PRNewswire/ ... firm dedicated to protecting the rights of victims ... problems have prompted regulators to call for better ... in 1990. Safety concerns involving power ... Drug Administration (FDA) to investigate how hospitals report ...
(Date:2/17/2017)... LONDON , February 17, 2017 Cryoablation, ... Urology The global ablation technologies market is expected to ... 9.7% from 2022-2027. The market is expected to grow at a ... at $3.3bn in 2016, and $9.05bn in 2026. ... How this report will benefit you ...
(Date:2/17/2017)... , Feb. 17, 2017 Arvinas LLC, ... drugs based on protein degradation, today announced the presentation ... (AR) PROTAC during a poster session at the American ... GU) in Orlando, FL. ... validate our platform and the potential of PROTACs to ...
Breaking Medicine Technology: