Navigation Links
Gail Besner, MD, receives RO1 grant to continue research on necrotizing enterocolitis
Date:10/23/2011

Gail Besner, MD, principal investigator in the Center for Perinatal Research in The Research Institute at Nationwide Children's Hospital, has been awarded a 4-year RO1 grant from the National Institutes of Health to continue her work on heparin-binding EGF-like growth factor (HB-EGF) and intestinal ischemia-reperfusion injury.

Dr. Besner, who holds the John E. Fisher Endowed Chair in Neonatal Research and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine, initially discovered HB-EGF in laboratory experiments with human white blood cells, and it was later found to be a member of the epidermal growth factor family of growth factors. This family of growth factors is important in regulating development and maintenance of various tissues.

Dr. Besner's research examines the ability of HB-EGF to treat and prevent various forms of intestinal injury including neonatal necrotizing enterocolitis (NEC). Primarily seen in premature infants, NEC is the most common and most serious gastrointestinal disorder among hospitalized preterm infants. It is also their leading cause of surgical death.

Recent data suggest that HB-EGF may not only serve to treat NEC, but may also improve intestinal function afterward. Based on her laboratory discoveries, approval has been received from the U.S. Food and Drug Administration to begin using HB-EGF in human clinical trials.

"Dr. Besner has been conducting this outstanding research at Nationwide Children's Hospital for the last 20 years," said R. Lawrence Moss, MD, surgeon-in-chief at Nationwide Children's Hospital. "This would be an impressive accomplishment for any researcher. For an individual who also manages a large clinical practice and directs a fellowship training program, the achievements are monumental. Dr. Besner's discoveries will positively influence the lives of babies with NEC around the world."

In addition to her role as a researcher in the Center for Perinatal Research, Dr. Besner also serves as the Program Director of the Pediatric Surgery Residency Training Program and as the Associate Burn Director at Nationwide Children's. She is a member of the American College of Surgeons Executive Committee of the Surgical Research Committee, and recently completed a 4-year term as a full-time member of the Surgery, Anesthesia and Trauma Study Section of the National Institutes of Health. The long range goal of Dr. Besner's work is the use of HB-EGF in the prophylactic and therapeutic treatment of neonates at high risk of developing NEC in order to prevent and treat this often devastating disease.


'/>"/>
Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related medicine news :

1. BUSM receives $13.6m grant to develop tools for the early detection of lung cancer
2. Einstein College of Medicine receives $5.7 million for developmental disabilities research
3. BGU professor receives US National Distinguished International Science Award for substance abuse work
4. SUNY receives $4.3 million for research in neuroscience, pediatric pharmacology and vision
5. Case Western Reserve receives prestigious $5.4 million grant to study esophageal cancer
6. Penn receives $12.5 million from NIH to speed discovery to patient care
7. Autism Speaks Autism Treatment Network receives $12 million AIR-P grant
8. AMRI receives FDA notification on proposed corrective actions
9. Brigham and Womens Hospital researcher receives NIH Transformative Research Project Award
10. First US patient receives specially processed donor lungs at the University of Maryland
11. University of Kentucky Sanders-Brown Center on Aging receives $7 million from NIA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
Breaking Medicine Technology: