Navigation Links
Gail Besner, MD, receives RO1 grant to continue research on necrotizing enterocolitis
Date:10/23/2011

Gail Besner, MD, principal investigator in the Center for Perinatal Research in The Research Institute at Nationwide Children's Hospital, has been awarded a 4-year RO1 grant from the National Institutes of Health to continue her work on heparin-binding EGF-like growth factor (HB-EGF) and intestinal ischemia-reperfusion injury.

Dr. Besner, who holds the John E. Fisher Endowed Chair in Neonatal Research and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine, initially discovered HB-EGF in laboratory experiments with human white blood cells, and it was later found to be a member of the epidermal growth factor family of growth factors. This family of growth factors is important in regulating development and maintenance of various tissues.

Dr. Besner's research examines the ability of HB-EGF to treat and prevent various forms of intestinal injury including neonatal necrotizing enterocolitis (NEC). Primarily seen in premature infants, NEC is the most common and most serious gastrointestinal disorder among hospitalized preterm infants. It is also their leading cause of surgical death.

Recent data suggest that HB-EGF may not only serve to treat NEC, but may also improve intestinal function afterward. Based on her laboratory discoveries, approval has been received from the U.S. Food and Drug Administration to begin using HB-EGF in human clinical trials.

"Dr. Besner has been conducting this outstanding research at Nationwide Children's Hospital for the last 20 years," said R. Lawrence Moss, MD, surgeon-in-chief at Nationwide Children's Hospital. "This would be an impressive accomplishment for any researcher. For an individual who also manages a large clinical practice and directs a fellowship training program, the achievements are monumental. Dr. Besner's discoveries will positively influence the lives of babies with NEC around the world."

In addition to her role as a researcher in the Center for Perinatal Research, Dr. Besner also serves as the Program Director of the Pediatric Surgery Residency Training Program and as the Associate Burn Director at Nationwide Children's. She is a member of the American College of Surgeons Executive Committee of the Surgical Research Committee, and recently completed a 4-year term as a full-time member of the Surgery, Anesthesia and Trauma Study Section of the National Institutes of Health. The long range goal of Dr. Besner's work is the use of HB-EGF in the prophylactic and therapeutic treatment of neonates at high risk of developing NEC in order to prevent and treat this often devastating disease.


'/>"/>
Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related medicine news :

1. BUSM receives $13.6m grant to develop tools for the early detection of lung cancer
2. Einstein College of Medicine receives $5.7 million for developmental disabilities research
3. BGU professor receives US National Distinguished International Science Award for substance abuse work
4. SUNY receives $4.3 million for research in neuroscience, pediatric pharmacology and vision
5. Case Western Reserve receives prestigious $5.4 million grant to study esophageal cancer
6. Penn receives $12.5 million from NIH to speed discovery to patient care
7. Autism Speaks Autism Treatment Network receives $12 million AIR-P grant
8. AMRI receives FDA notification on proposed corrective actions
9. Brigham and Womens Hospital researcher receives NIH Transformative Research Project Award
10. First US patient receives specially processed donor lungs at the University of Maryland
11. University of Kentucky Sanders-Brown Center on Aging receives $7 million from NIA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... Francisco, CA (PRWEB) , ... October 12, 2017 ... ... Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent ... apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
(Date:10/12/2017)... Rockville, Maryland (PRWEB) , ... October 12, 2017 ... ... a magnetic drug delivery system that we intend to develop to enable prevention ... regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts ... Washington, D.C., for the 49th Congress of the International Society of Paediatric Oncology ... of the Center for Cancer and Blood Disorders at Children’s National, and ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Oct. 12, 2017 AVACEN Medical , Inc. ... with their  2017 New Product Innovation Award for Its ... primary and secondary medical device market research by Frost & ... first-to-market OTC, drug-free pain relief product, the AVACEN 100, offers ... treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ® ... fulfilling the promise of precision medicine, today announced that ... Caris, Precision Oncology Alliance™ (POA) as its 17 th ... the St. Jude Crosson Cancer Institute will help develop ... use of tumor profiling, making cancer treatment more precise ...
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
Breaking Medicine Technology: