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Gabriel Hortobagyi honored for mentoring minority researchers
Date:4/10/2013

ical trials to develop treatment regimens that have become standard practices for managing breast cancer.

"Dr. Hortobagyi is well-known for his groundbreaking research, his outstanding patient care and leadership in the field and at MD Anderson," said Waun Ki Hong, M.D., head of MD Anderson's Division of Cancer Medicine and vice provost of clinical research. "We're proud to see him recognized for his success as a dedicated, diligent mentor to young investigators."

The lectureship is named in honor of Jane Cooke Wright, M.D., a pioneer in clinical cancer chemotherapy research who recently passed away at the age of 93. Wright, a member of the AACR since 1954, became the highest ranking black woman at a nationally recognized medical institution in 1967. She was elected this year into the inaugural class of the Fellows of the AACR Academy.

Early in his career, Hortobagyi conducted a landmark study that gave chemotherapy before surgery to breast cancer patients with locally advanced tumors that had not spread to other parts of the body. The study concluded that most large tumors could be reduced by at least 50 percent with the preoperative chemotherapy and then removed surgically. He also:

  • With colleagues first described pathological complete response as a surrogate therapeutic endpoint in patients treated with preoperative chemotherapy. The U.S. Food and Drug Administration is considering accepting this endpoint for accelerated drug approval.

  • Published a study that showed a three-drug regimen administered before surgery, and radiation therapy after surgery, produced promising results for breast cancer patients with advanced disease. This approach was later applied with increased success to earlier stage disease.

  • Co-led the international Phase III clinical trial of the mTOR inhibitor Affinitor that led last year to U.S. Food and Drug Administration approval of the drug in combination with an aromata
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Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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