Navigation Links
GW researcher receives grant to develop genetic tools to study parasitic infections
Date:8/11/2014

WASHINGTON (Aug. 11, 2014) According to a recent World Health Organization report of the leading causes of death worldwide, one-third of all deaths are due to infectious and parasitic diseases. There are currently no vaccines for parasitic nematode (PN), or worm infections in humans, and development of new drugs and vaccines will stall until researchers have a better understanding of PN biology.

John Hawdon, Ph.D., associate professor of microbiology, immunology, and tropical medicine at the George Washington University (GW) School of Medicine and Health Sciences, was recently awarded $430,722 from the National Institutes of Health to develop a model system to study PN infection, which will lead to greater understanding of the infective process and the host's immune response to infection.

Due to the requirement of an obligate host and lack of good animal models, investigations have been previously limited. However, thanks to an interdisciplinary team, which includes Hawdon, Damien O'Halloran, Ph.D., and Ioannis Eleftherianos, Ph.D., both assistant professors of biology at the GW Columbian College of Arts and Sciences, a viable model will be developed using the insect PN Heterorhabditis bacteriophora.

"The techniques we are developing will allow us to practice RNA interference and transgenesis, which will allow us to insert copies of DNA into the nematode, look at gene function, and knock out certain genes," said Hawdon. "This research fills a need for further development of these techniques in this worm."

The research team will focus on targeting the infective juvenile and early parasitic stages in order to investigate infection mechanisms. Their approaches will provide a foundation for future investigation into the mechanism of PN infection.

The development of these methods for gene knock down, or reverse genetics, and transfection in this novel model nematode would represent a significant advance for PN research, and will facilitate investigation of PN gene function during infection.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Stress contributes to cognitive declines in women with breast cancer, researcher says
9. Researchers Map Brain Regions Linked to Intelligence
10. Researchers ID Genes That May Determine Mental Illness
11. Researchers Develop Blood Test for Depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... The ... MSC Cruises as part of the line’s 4th Annual MSC True Partnerships’ Awards. ... performing North American travel partners for the year based on overall business growth in ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... advance to the semi-final round of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired ... its 12th year in 2017. The entrepreneurs will showcase their businesses on February ...
(Date:1/24/2017)... ... January 24, 2017 , ... West’s Health Advocate Solutions, ... Series of webinars will start January 31 with a session about understanding healthcare ... health and benefits topics, including employee engagement, pricing transparency, population health and wellness, ...
(Date:1/24/2017)... ... ... His message has been heard by more than 100,000 students and adults ... Joel Feldman, has reached his biggest national audience yet: the three million daily readers ... in circulation in the country, and he hopes it will help spread his message ...
(Date:1/24/2017)... Santa Margarita, CA (PRWEB) , ... January 24, 2017 , ... ... advancement platform for 21st century leadership, has named Hector M. Chavez, Manager, Employee & ... and diabetes treatment center - as its Hispanic Leader of the Month. City of ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- Trifecta Clinical , a leading global provider ... Ward to Vice President of Commercial Operations.  Rick ... the promotion of Ericka Atkinson to Vice ... joins Trifecta from Greenphire where he was Vice President ... positions within the healthcare industry throughout his career.  "Rick ...
(Date:1/24/2017)... Research and Markets has announced the addition of the "Implantable ... to 2025" report to their offering. ... The Global Implantable Medical Devices Market ... the next decade to reach approximately $54.28 billion by 2025 ... include 3D medical printing is expected to develop and find in ...
(Date:1/24/2017)... , and GAITHERSBURG, Md. , Jan. 24, ... ), a leader in the engineering and industrialization of biology ... planet, today announced that it has entered into a definitive ... GNVC ), a clinical-stage company and pioneer in the development ... to integrate and expand upon GenVec,s expertise in adenoviral vectors ...
Breaking Medicine Technology: