Navigation Links
GW researcher receives grant to develop genetic tools to study parasitic infections
Date:8/11/2014

WASHINGTON (Aug. 11, 2014) According to a recent World Health Organization report of the leading causes of death worldwide, one-third of all deaths are due to infectious and parasitic diseases. There are currently no vaccines for parasitic nematode (PN), or worm infections in humans, and development of new drugs and vaccines will stall until researchers have a better understanding of PN biology.

John Hawdon, Ph.D., associate professor of microbiology, immunology, and tropical medicine at the George Washington University (GW) School of Medicine and Health Sciences, was recently awarded $430,722 from the National Institutes of Health to develop a model system to study PN infection, which will lead to greater understanding of the infective process and the host's immune response to infection.

Due to the requirement of an obligate host and lack of good animal models, investigations have been previously limited. However, thanks to an interdisciplinary team, which includes Hawdon, Damien O'Halloran, Ph.D., and Ioannis Eleftherianos, Ph.D., both assistant professors of biology at the GW Columbian College of Arts and Sciences, a viable model will be developed using the insect PN Heterorhabditis bacteriophora.

"The techniques we are developing will allow us to practice RNA interference and transgenesis, which will allow us to insert copies of DNA into the nematode, look at gene function, and knock out certain genes," said Hawdon. "This research fills a need for further development of these techniques in this worm."

The research team will focus on targeting the infective juvenile and early parasitic stages in order to investigate infection mechanisms. Their approaches will provide a foundation for future investigation into the mechanism of PN infection.

The development of these methods for gene knock down, or reverse genetics, and transfection in this novel model nematode would represent a significant advance for PN research, and will facilitate investigation of PN gene function during infection.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Stress contributes to cognitive declines in women with breast cancer, researcher says
9. Researchers Map Brain Regions Linked to Intelligence
10. Researchers ID Genes That May Determine Mental Illness
11. Researchers Develop Blood Test for Depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Technique, technique, technique – ... when either lifting weights for strength training and exercise or simply lifting heavy objects, ... , “Body position is everything,” Dr. Chang says. “Improper technique in lifting anything heavy ...
(Date:5/23/2017)... ... May 23, 2017 , ... MDLand International (MDLand), a ... today that its iClinic V12.2 solution has achieved approval from National Center for ... PCMH 2017 standards which emphasize team-based care with a significant focus on the ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... Allegheny ... to open The Alexis Joy D’Achille Center for Women’s Behavioral Health at West ... available in western Pennsylvania for women suffering from pregnancy-related depression. Construction of the ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... Carolina have remained steady since 2009, according to a Workers Compensation Research Institute ... study Monitoring the North Carolina System: CompScope™ Benchmarks, 17th Edition looks ...
(Date:5/23/2017)... Rosa, California (PRWEB) , ... May 23, 2017 ... ... health management (PHM) technology and a 2017 Best in KLAS category winner, has ... advantageous market position to extend and enhance its technology platform and product offerings,” ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... CHICAGO , May 5, 2017  May is ... of one of the most important methods to prevent ... to the Centers for Disease Control and Prevention, undetected ... stroke. 1 Omron, the global leader in personal ... on the elimination of heart attack and stroke and ...
(Date:5/4/2017)... , May 4, 2017  Fortuna Fix Inc. (" ... to be the first to eliminate the need for embryonic ... cells to treat neurodegenerative diseases. Fortuna ... with Professor Michael Fehlings , MD, PhD; Father ... , MD, MPH; and Professor James Giordano , PhD. ...
(Date:5/4/2017)... Clarius Mobile Health, a digital healthcare ... this week at the American Congress of Obstetricians ... San Diego, CA from May ... perfect tool for clinicians to easily confirm pregnancy, ... pregnancy-related complications like ectopic pregnancy and placenta previa," ...
Breaking Medicine Technology: