Navigation Links
GW researcher finds gene therapy a promising tool for cardiac regeneration
Date:2/20/2014

WASHINGTON (Feb. 20, 2014) After a heart attack, there is often permanent damage to a portion of the heart. This happens, in part, because cardiac muscle cells are terminally differentiated and cannot proliferate after blood flow is blocked off to the heart. This partial healing can be attributed to heart disease being one of the leading causes of death. What if the cells could be stimulated to divide and the heart could be induced to repair itself? This was the question posed by George Washington University (GW) researcher Scott Shapiro, M.D., Ph.D., and his co-authors, who found that cardiac regeneration may be a possibility with gene therapy.

The research, published yesterday in Science Translational Medicine, found that gene therapy can elicit a regenerative response in pig hearts. Shapiro and his research team first looked to small animals such as the zebrafish, which are able to regenerate heart tissue after a heart attack. This animal has a key protein at play, Cyclin A2 (Ccna2).

"After seeing the effects of CCna2 in small animals, we began looking at the effects of the gene in larger animals, such as pigs," said Shapiro, assistant professor of medicine at the GW School of Medicine and Health Sciences. "We delivered Ccna2 directly into the heart and found that pigs not only had improved cardiac function, but also found evidence of cellular regeneration."

Ccna2 is a prenatal gene normally turned off in humans after birth. Shapiro believes using gene therapy as a tool for cardiac regeneration, optimized for humans, could lead to a viable treatment option for patients who suffer from myocardial infarction, or heart attack.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1

Related medicine news :

1. MD Anderson researcher uncovers some of the ancient mysteries of leprosy
2. Researchers look for culprit behind oral health problems in HIV-positive patients
3. Clemson researchers develop sticky nanoparticles to fight heart disease
4. NUS researchers make new discovery of protein as a promising target for treatment of ATC
5. Scripps researchers recommend mobile compression device to prevent DVT after joint surgery
6. No such thing as porn addiction, researchers say
7. LA BioMed researchers report on promising new therapy for devastating genetic disorder
8. NIH-funded researchers use antibody treatment to protect humanized mice from HIV
9. Researchers blend orthopedics, engineering to better repair torn rotator cuffs
10. Researcher attacks pre-term labor problem
11. Researchers discover new hormone receptors to target when treating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... one of your worst memories? How did it make ... during a negative personal experience, such as how sad ... to emotional distress, especially when you can,t stop thinking ... up, thinking about the context of the memories, rather ... effective way to alleviate the negative effects of these ...
(Date:4/18/2014)... Fraser University psychologists have made a brain-related discovery ... attention-deficit disorders. , This discovery opens up the ... or suppress a specific brain activity that the ... , The Journal of Neuroscience has ... John McDonald, an associate professor of psychology and ...
(Date:4/18/2014)... . A ... A team led by Ludwik Leibler from the Laboratoire ... Letourneur from the Laboratoire Recherche Vasculaire Translationnelle (INSERM/Universits Paris ... principle of adhesion by aqueous solutions of nanoparticles can ... tissues. This easy-to-use gluing method has been tested on ...
(Date:4/17/2014)... in benign prostate tissue was associated with high-grade, ... found even in those with low prostate-specific antigen ... Cancer Epidemiology, Biomarkers & Prevention , a ... , An analysis of prostate tissue biopsies collected ... the Prostate Cancer Prevention Trial (PCPT) found that ...
(Date:4/17/2014)... first genetic variant specifically associated with the risk ... 10-15 per cent of all breast cancer cases. ... cancer sub-type, called invasive lobular carcinoma, gives researchers ... particular kind of breast cancer, which can be ... (Thursday) in the journal PloS Genetics , ...
Breaking Medicine News(10 mins):Health News:New study suggests a better way to deal with bad memories 2Health News:New study suggests a better way to deal with bad memories 3Health News:Scientists discover brain's anti-distraction system 2Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3
... Nov. 26 David B. Snow,chairman & chief executive ... to address the Merrill Lynch & Co., Inc. 2007 ... presentation at Merrill Lynch headquarters, New York, will begin ... and Richard J.,Rubino, CPA, Medco,s controller and chief accounting ...
... CHICAGO, Nov. 26 All-terrain vehicles (ATVs) pose a,serious ... largest study ever,conducted of ATV injuries in children. The ... Radiological Society of North America (RSNA)., "Our experience ... be restricted," said Chetan C. Shah, M.D., radiology fellow ...
... women have a different understanding of screening mammography ... the findings of a Boston University Medical Center ... the Radiological Society of North America (RSNA). , ... ethnic and socioeconomic groups, said Nazia F. Jafri, ...
... PHILADELPHIA Researchers at the University of Pennsylvania School ... transcranial magnetic stimulation (TMS) a non-invasive technique that ... through the scalp is a safe and effective, ... major depression who have tried other treatment options without ...
... and its there in bright medical images: evidence of ... secondhand cigarette smoke. For the first time, researchers have ... but not previously detectable with medical imaging tools. ... public health efforts to restrict secondhand smoke. , ...
... FAAN, FAHA, a clinical professor of neurology at Boston ... the Framingham Heart Study, was recently awarded the Stroke ... award was presented at the AHAs recent Scientific Sessions ... Award recognizes and encourages those who actively work to ...
Cached Medicine News:Health News:Medco CEO to Present at the Merrill Lynch & Co., Inc. 2007 Health Services Investor Conference 2Health News:Injury Report Shows All-Terrain Vehicles Not Child's Play 2Health News:Injury Report Shows All-Terrain Vehicles Not Child's Play 3Health News:Attitudes toward mammography differ across ethnicities, cultures, backgrounds 2Health News:Penn research shows transcranial magnetic stimulation effective in treating major depression 2Health News:Secondhand smoke damages lungs, MRIs show 2
(Date:1/15/2014)...  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the ... Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ) ... in order to treat dental impairments, for tooth restoration ...
(Date:1/15/2014)... IRVING, Texas , Jan. 15, 2014  Novation, the ... company, awarded several new IT value-added reseller (VAR) national ... with IT goods and services at lower costs. These ... value-added services such as initiative assistance and ongoing IT ...
(Date:1/15/2014)... 2014 Shire plc (LSE: SHP, NASDAQ: ... Trading (OFT) approval condition to the announced tender offer for all ... As a result of the waiver, the transaction is no ... tender offer on January 24, 2014 following the currently scheduled expiration ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
... Pharmaceuticals, Inc. (Nasdaq: CADX ) today announced that ... of its common stock at a price to the public ... of the shares, after deducting the underwriting discounts and commissions ... million.  Cadence has granted the underwriters for the offering a ...
... NEW YORK, Nov. 15, 2011 Reportlinker.com ... is available in its catalogue: ... East Asia ... analysis of four pharmaceutical markets that present ...
Cached Medicine Technology:Cadence Pharmaceuticals Announces Pricing of Public Offering of Common Stock 2Cadence Pharmaceuticals Announces Pricing of Public Offering of Common Stock 3The Outlook for Pharmaceuticals in North East Asia 2The Outlook for Pharmaceuticals in North East Asia 3The Outlook for Pharmaceuticals in North East Asia 4
... and removal in the urinary tract. The nitinol ... shape following extreme torsion. The unique tipless design ... basket to open at the base of the ... reduces the likelihood of mucosal damage and perforation. ...
... Filiform Spiral Tip 12 Inch , 20 ... female thread. Available in 3,4,5 6Fr. These ... strong but flexible polymer material and have ... other brands. They are manufactured to the ...
... for stone manipulation and removal in the urinary ... Delta Wire. The revolutionary triangular shape of Delta ... largest possible wire mass. The superior mass of ... qualities of nitinol alloy, creates a basket with ...
... SILASTIC Brand Latex Foley Catheter, Smooth, ... build-up, Firm, but flexible, latex-based construction ... length - round tip with two ... (336xx) or two staggered eyes and ...
Medicine Products: