Navigation Links
GW researcher discovers the mechanisms that link brain alertness and increased heart rate
Date:5/6/2014

WASHINGTON (May 6, 2014) George Washington University (GW) researcher David Mendelowitz, Ph.D., was recently published in the Journal of Neuroscience for his research on how heart rate increases in response to alertness in the brain. Specifically, Mendelowitz looked at the interactions between neurons that fire upon increased attention and anxiety and neurons that control heart rate to discover the "why," "how," and "where to next" behind this phenomenon.

"This study examines how changes in alertness and focus increase your heart rate," said Mendelowitz, vice chair and professor of pharmacology and physiology at the GW School of Medicine and Health Sciences. "If you need to focus on a new task at hand, or suddenly need to become more alert, your heart rate increases. We sought to understand the mechanisms of how that happens."

While the association between vigilance and increased heart rate is long accepted, the neurobiological link had not yet been identified. In this study, Mendelowitz found that locus coeruleus (LC) noradrenergic neurons neurons critical in generating alertness directly influence brainstem parasympathetic cardiac vagal neurons (CVNs) neurons responsible for controlling heart rate. LC noradrenergic neurons were shown to inhibit the brainstem CVNs that generate parasympathetic activity to the heart. The receptors activated within this pathway may be targets for new drug therapies to promote slower heart rates during heightened states.

"Our results have important implications for how we may treat certain conditions in the future, such as post-traumatic stress disorder, chronic anxiety, or even stress," said Mendelowitz. "Understanding how these events alter the cardiovascular system gives us clues on how we may target these pathways in the future."


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Stress contributes to cognitive declines in women with breast cancer, researcher says
9. Researchers Map Brain Regions Linked to Intelligence
10. Researchers ID Genes That May Determine Mental Illness
11. Researchers Develop Blood Test for Depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... CA (PRWEB) , ... January 19, 2017 , ... Bill ... 2017 collaboration with the American Heart Association; “Howe” Healthy is Your Heart Drawing ... stay healthy and active. Each year, Bill Howe Plumbing, Heating & Air receives over ...
(Date:1/19/2017)... MD (PRWEB) , ... January 19, 2017 , ... Sales ... six new clients into the US market. , Over the past 20 years SFI ... past 4 weeks SFI has launched six new clients into the US market. ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... Breast Surgery Symposium, a conference where hundreds of surgeons from over fifteen different ... Covering topics from cosmetic breast augmentation to breast reconstruction for breast ...
(Date:1/18/2017)... ... January 18, 2017 , ... A recent video posting of a new ... the benefits of fidgeting to relieve stress and anxiety. No one was more ... Ink Pen had just completed a successful Kickstarter campaign raising $67,000 on the popular ...
(Date:1/18/2017)... ... January 18, 2017 , ... Visually learn facts and ... OTC antiperspirant, Certain Dri. , Excessive sweating and hyperhidrosis are common conditions that ... infographic to explain the seven types of hyperhidrosis. This visual creates awareness about ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , January 19, 2017 ... Option to Address Motor Symptoms and Motor Complications ... ...      (Logo: http://photos.prnewswire.com/prnh/20151014/276718LOGO) ... , European Neurological Review,2016;11(Suppl. 2): 2-15, http://www.touchneurology.com/articles/safinamide-new-therapeutic-option-address-motor-symptoms-and-motor-complications-mid-late ...
(Date:1/19/2017)... , Jan. 18, 2017 The Global Therapy ... and access to partnering deals and agreements entered into ... in partnering deals - Top deals by value - ... development, technology type The report provides understanding and ... by the world,s leading healthcare companies. The report ...
(Date:1/19/2017)... South Korea Insulin Delivery Market Outlook ... Korea Insulin Delivery Market Outlook to 2022", provides key ... The report provides value, in millions of US dollars, ... segments - Insulin Pens, Insulin Pumps, Insulin Syringes and ... company shares and distribution shares data for each of ...
Breaking Medicine Technology: