Navigation Links
GW Researcher receives grant to study parasitic worm role in bile duct cancer in Southeast Asia
Date:11/16/2012

WASHINGTON (Nov. 16, 2012) Paul Brindley, Ph.D., professor of microbiology, immunology, and tropical medicine at the George Washington University School of Medicine and Health Sciences, was the recipient of a $1.7 million grant from the National Cancer Institute to study the behavior of a parasitic worm, rampant in Southeast Asia, known to cause infections that contribute to liver cancer.

The idea for his project, titled "Role of Live Fluke Granulin in Cholangiocarcinogenesis," was introduced to Brindley several years ago by a Thai postdoctoral student. In Thailand, the student had seen a disproportionately large amount of instances of a specific type of bile duct cancer, not common in the Western Hemisphere. It was discovered that this type of bile duct cancer, cholangiocarcinoma, is brought on by a parasitic worm that lives in uncooked fresh water fish, often present in traditional dishes in the region. The worm thrives in Southeast Asia due to unsanitary practices and conditions. The cancer caused by the worm usually results in death.

"With this grant we will research how a parasite could cause cancer," said Brindley. "What is it doing in someone's liver or bile ducts that's turning otherwise normal tissue into a tumor?"

The worm, which is large enough to be seen without a microscope, releases a product called granulin while navigating through the human body. In humans and other mammals, granulin is used to stimulate cells to grow and divide in order to heal a cut or a wound. When a worm secretes granulin, it seems to enhance a tumorigenic environment.

"In an evolutionary sense, we don't see the value to a parasite of causing a tumor to grow around it," said Brindley. "If a person dies, the worm dies, too. Why would a worm induce a tumor?"

Over the next five years, Brindley's research team in the U.S., Australia, and Thailand will be focused on the effect this granulin secretion has on a human's liver cells. While a difficult hypothesis to prove, Brindley and his colleagues suggest that because there is a wound or lesion where the worm has passed, the worm intends to repair the damage it's causing by releasing granulin. That way, in a few days the worm could return to the same place and eat the cells again. If proven, a drug or medical treatment may be developed to help with the effects of granulin on tissue growth.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Related medicine news :

1. Researchers outline effective strategies to prevent teen depression and suicide
2. Researchers report potential new treatment to stop Alzheimers disease
3. Feinstein Institute researchers discover plant derivative
4. Researcher: Military should reassess reproductive health care for women
5. GW researcher receives $4.1 million grant to find alternative treatment for kidney stones
6. Coca-Cola model for delivering malaria meds is a success, says Princeton researcher
7. Sociology, economics researchers receive grant to study development across the human lifespan
8. Emotional disconnection disorder threatens marriages, researcher says
9. Genital Injuries Common But Preventable, Researchers Say
10. Researchers identify impact of rheumatoid arthritis and lupus on joint replacement surgery outcomes
11. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
(Date:9/22/2017)... 2017  As the latest Obamacare repeal effort moves ... (R-LA) and Lindsey Graham (R-SC) medical ... device industry is in an odd place.  The industry ... excise tax on medical device sales passed along with ... patients, increased visits and hospital customers with the funding ...
(Date:9/19/2017)... LOUISVILLE, Ky. , Sept. 19, 2017   ZirMed ... and predictive analytics, today announced that it has been ranked ... the Black Book™ Rankings 2017 User Survey. ZirMed ... software solution for large hospitals and medical centers over 200 ... in Black Book,s healthcare technology user survey history. ...
Breaking Medicine Technology: