Navigation Links
GW Researcher receives grant to study parasitic worm role in bile duct cancer in Southeast Asia

WASHINGTON (Nov. 16, 2012) Paul Brindley, Ph.D., professor of microbiology, immunology, and tropical medicine at the George Washington University School of Medicine and Health Sciences, was the recipient of a $1.7 million grant from the National Cancer Institute to study the behavior of a parasitic worm, rampant in Southeast Asia, known to cause infections that contribute to liver cancer.

The idea for his project, titled "Role of Live Fluke Granulin in Cholangiocarcinogenesis," was introduced to Brindley several years ago by a Thai postdoctoral student. In Thailand, the student had seen a disproportionately large amount of instances of a specific type of bile duct cancer, not common in the Western Hemisphere. It was discovered that this type of bile duct cancer, cholangiocarcinoma, is brought on by a parasitic worm that lives in uncooked fresh water fish, often present in traditional dishes in the region. The worm thrives in Southeast Asia due to unsanitary practices and conditions. The cancer caused by the worm usually results in death.

"With this grant we will research how a parasite could cause cancer," said Brindley. "What is it doing in someone's liver or bile ducts that's turning otherwise normal tissue into a tumor?"

The worm, which is large enough to be seen without a microscope, releases a product called granulin while navigating through the human body. In humans and other mammals, granulin is used to stimulate cells to grow and divide in order to heal a cut or a wound. When a worm secretes granulin, it seems to enhance a tumorigenic environment.

"In an evolutionary sense, we don't see the value to a parasite of causing a tumor to grow around it," said Brindley. "If a person dies, the worm dies, too. Why would a worm induce a tumor?"

Over the next five years, Brindley's research team in the U.S., Australia, and Thailand will be focused on the effect this granulin secretion has on a human's liver cells. While a difficult hypothesis to prove, Brindley and his colleagues suggest that because there is a wound or lesion where the worm has passed, the worm intends to repair the damage it's causing by releasing granulin. That way, in a few days the worm could return to the same place and eat the cells again. If proven, a drug or medical treatment may be developed to help with the effects of granulin on tissue growth.


Contact: Lisa Anderson
George Washington University

Related medicine news :

1. Researchers outline effective strategies to prevent teen depression and suicide
2. Researchers report potential new treatment to stop Alzheimers disease
3. Feinstein Institute researchers discover plant derivative
4. Researcher: Military should reassess reproductive health care for women
5. GW researcher receives $4.1 million grant to find alternative treatment for kidney stones
6. Coca-Cola model for delivering malaria meds is a success, says Princeton researcher
7. Sociology, economics researchers receive grant to study development across the human lifespan
8. Emotional disconnection disorder threatens marriages, researcher says
9. Genital Injuries Common But Preventable, Researchers Say
10. Researchers identify impact of rheumatoid arthritis and lupus on joint replacement surgery outcomes
11. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
Post Your Comments:
(Date:11/28/2015)... ... , ... Pixel Film Studios is back again with ProPanel: Pulse . ... endless. Users have full control over angle of view, speed method, start point, end ... to get heads to turn. , ProPanel: Pulse offers fully customizable pulsating shape masks, ...
(Date:11/27/2015)... ... , ... The rapid speed at which Americans are aging ... is needed, especially with Alzheimer’s, dementia and other cognitive conditions becoming more prevalent. ... part of this equation: 80 percent of medical care occurs in the home, ...
(Date:11/27/2015)... ... November 27, 2015 , ... The print ... USA Today in Atlanta, Dallas, New York, Minneapolis, South Florida, with a circulation ... is distributed nationally, through a vast social media strategy and across a network ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, "Voices ... show that delves into an array of issues that are presently affecting Americans. Dedicated ... open dialogue, this show is changing the subjects consumers focus on, one episode at ...
(Date:11/27/2015)... ... November 27, 2015 , ... Dr. Thomas Dunlap ... Inc. and Dr. Tucker Bierbaum with Emergency Medicine at St., Joseph Health ... both STEMI and Sepsis conditions present in similar ways and require time-critical intervention to ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Marker Testing Market: Supplier Shares, Competitive ... offering.  --> ) ... "2016 Future Horizons and Growth Strategies ...
(Date:11/25/2015)... 25, 2015  The American Academy of Pediatrics ... and the March of Dimes cheered today,s signature ... Infants Act of 2015 (S.799), which takes ... born exposed to drugs, such as opioids, and ... all three organizations have worked together leading advocacy ...
(Date:11/25/2015)... -- ARKRAY USA , Inc., a leader ... the accuracy of its blood glucose meter systems. Last ... and Cardiovascular Disease in Los Angeles ... 01 meter and the Assure ® Prism ... accurately measure glucose levels in blood is essential for ...
Breaking Medicine Technology: