Navigation Links
GW Researcher receives grant to study parasitic worm role in bile duct cancer in Southeast Asia
Date:11/16/2012

WASHINGTON (Nov. 16, 2012) Paul Brindley, Ph.D., professor of microbiology, immunology, and tropical medicine at the George Washington University School of Medicine and Health Sciences, was the recipient of a $1.7 million grant from the National Cancer Institute to study the behavior of a parasitic worm, rampant in Southeast Asia, known to cause infections that contribute to liver cancer.

The idea for his project, titled "Role of Live Fluke Granulin in Cholangiocarcinogenesis," was introduced to Brindley several years ago by a Thai postdoctoral student. In Thailand, the student had seen a disproportionately large amount of instances of a specific type of bile duct cancer, not common in the Western Hemisphere. It was discovered that this type of bile duct cancer, cholangiocarcinoma, is brought on by a parasitic worm that lives in uncooked fresh water fish, often present in traditional dishes in the region. The worm thrives in Southeast Asia due to unsanitary practices and conditions. The cancer caused by the worm usually results in death.

"With this grant we will research how a parasite could cause cancer," said Brindley. "What is it doing in someone's liver or bile ducts that's turning otherwise normal tissue into a tumor?"

The worm, which is large enough to be seen without a microscope, releases a product called granulin while navigating through the human body. In humans and other mammals, granulin is used to stimulate cells to grow and divide in order to heal a cut or a wound. When a worm secretes granulin, it seems to enhance a tumorigenic environment.

"In an evolutionary sense, we don't see the value to a parasite of causing a tumor to grow around it," said Brindley. "If a person dies, the worm dies, too. Why would a worm induce a tumor?"

Over the next five years, Brindley's research team in the U.S., Australia, and Thailand will be focused on the effect this granulin secretion has on a human's liver cells. While a difficult hypothesis to prove, Brindley and his colleagues suggest that because there is a wound or lesion where the worm has passed, the worm intends to repair the damage it's causing by releasing granulin. That way, in a few days the worm could return to the same place and eat the cells again. If proven, a drug or medical treatment may be developed to help with the effects of granulin on tissue growth.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Related medicine news :

1. Researchers outline effective strategies to prevent teen depression and suicide
2. Researchers report potential new treatment to stop Alzheimers disease
3. Feinstein Institute researchers discover plant derivative
4. Researcher: Military should reassess reproductive health care for women
5. GW researcher receives $4.1 million grant to find alternative treatment for kidney stones
6. Coca-Cola model for delivering malaria meds is a success, says Princeton researcher
7. Sociology, economics researchers receive grant to study development across the human lifespan
8. Emotional disconnection disorder threatens marriages, researcher says
9. Genital Injuries Common But Preventable, Researchers Say
10. Researchers identify impact of rheumatoid arthritis and lupus on joint replacement surgery outcomes
11. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
Breaking Medicine Technology: