Navigation Links
GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
Date:2/16/2010

chers set out to study if, as previous research had suggested, tamoxifen resistance is regulated by the protein complex NF- κB (nuclear factor kappa B), which is often found to be over-expressed in ER+ breast cancer. NF- κB is known to help cells survive when damaged.

The researchers had earlier discovered that NF- κB is over-expressed in cells that are resistant to tamoxifen, and they had found that resistance to another tamoxifen-like drug, fulvestrant, was controlled by a protein (Bcl2) that is, itself, regulated by NF- κB.

"Our scientific quest was to see if blocking NF- κB affects tamoxifen resistance, and if it does, why?" says Clarke.

They conducted a variety of tests using parthenolide, which has been shown to act on NF- κB. They found that in resistant breast cancer cells, the chemical blocked the activity of NF- κB, making the cells sensitive once again to tamoxifen. They then silenced NF- B in tamoxifen resistant cells, and found that this had the same effect as using parthenolide.

They further found that increased activation of NF- κB can alter sensitivity of tamoxifen by modulating the protein CASP8, which is involved in programmed cell death. That then affects Bcl2, which also helps push a damaged cell to die.

"When you give tamoxifen to a breast cancer cell, that is essentially a pro-death signal, because you are blocking the cell's access to estrogen, and the cell recognizes this is a mortal blow," Clarke says. "Such a damaged cell uses CASP8 and Bcl2 to trigger the cell machinery needed for dying.

"But the cell has ways to counteract the pro-death signal, and one important one is to activate NF- κB, which can control expression of genes necessary for survival," he says. "Now the cell thinks it should be living, not dying."

Because NF- κB controls CASP8 and Bcl2, it can turn those proteins essentially off, Clarke says. "The pro-survival signals override th
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2015)... Indiana Fiber Network, LLC (IFN), the ... Mutual Insurance Company has selected IFN as a fiber ... at Brotherhood Mutual Insurance Company states: “IFN’s broadband fiber ... Mutual needed. We were interested in building ... us to ensure we achieved both. ” ...
(Date:4/26/2015)... India Network Foundation, a non-profit organization ... services to the Asian Indian community in the United ... more than two decades. The India News Network Digest ... around the world with the latest news items from ... Immigration Law Forum Digest, edited and contributed by Sheela ...
(Date:4/26/2015)... 2015 The grand celebration got off to ... Dettor, CCAR’s Managing Director. Deb then introduced Sandy Valentine, the ... in attendance because of his Walk for Recovery ... able to express his gratitude to the volunteers via video. ... dedication to carrying out CCAR’s mission. Volunteer Manager Conrad ...
(Date:4/25/2015)... Francisco, California (PRWEB) April 26, 2015 ... his search for original 1965 Rolling Stones Greensboro Coliseum concert ... and was part of the Stone's Second American Tour. ... by Globe Poster Company out of Baltimore, Maryland. This ... in the northeast and southern cites. Globe uses garish ...
(Date:4/25/2015)... York, New York (PRWEB) April 25, 2015 ... ) established for vaginal mesh lawsuits filed against ... the U.S. District Court, Southern District of West ... 9th, a Scheduling Conference was convened that day, ... Plaintiffs’ Master Long Form Complaint. The Order directed ...
Breaking Medicine News(10 mins):Health News:Brotherhood Mutual Insurance Company Selects Indiana Fiber Network, LLC for Fiber Transport Service 2Health News:Brotherhood Mutual Insurance Company Selects Indiana Fiber Network, LLC for Fiber Transport Service 3Health News:North American Telugu Society Bestows Community Service Award to India Network Foundation for Its Generosity and Sponsor of Visitor Health Insurance to Indian Visitors 2Health News:North American Telugu Society Bestows Community Service Award to India Network Foundation for Its Generosity and Sponsor of Visitor Health Insurance to Indian Visitors 3Health News:The Connecticut Community for Addiction Recovery (CCAR) honors its volunteers during National Volunteer Recognition Week. 2Health News:C.R. Bard Vaginal Mesh Lawsuit News: Federal Litigation Issues New Pretrial Order Following Submission of Amended Responses to Master Complaint 2Health News:C.R. Bard Vaginal Mesh Lawsuit News: Federal Litigation Issues New Pretrial Order Following Submission of Amended Responses to Master Complaint 3Health News:C.R. Bard Vaginal Mesh Lawsuit News: Federal Litigation Issues New Pretrial Order Following Submission of Amended Responses to Master Complaint 4
... taken on time , , WEDNESDAY, May 7 (HealthDay News) -- ... miss doses when reminded by an electronic pillbox that both ... of pills to take and how to take them, new ... National Institute on Aging, was presented recently at the American ...
... SPOKANE, Wash., May 7 MIPSolutions, Inc. (OTC,Bulletin ... the,University of Utah has revealed a significant development ... that Molecularly Imprinted,Ionomer (MII) beads imprinted to retain ... This translates into decreased development,time, a large amount ...
... in Spanish and Chinese . ... translational research grant program will fund a pilot ... appropriate and improved diabetes care in rural communities ... Diabetes Self-Management Program (DSME), will help Filipinos with ...
... DaVita Inc. (NYSE:,DVA) announced that its Board ... current stock repurchase program. The increase, together ... $250,000,000 of,the Company,s common stock. The stock ... http://www.newscom.com/cgi-bin/prnh/20020729/DAVITALOGO ), Rich Whitney, CFO, ...
... May 7 Vaccinogen Inc. said Dutch health,authorities licensed ... clearing the path to more than $100 million of,potential ... facility based in Emmen, The,Netherlands also paves the way ... the final step before the vaccine can be sold ...
... Despite a weakened economy, a,challenging airline industry, and ... summer vacation plans, travel industry experts,observe; but they ... ), Jim Grace, President and CEO of ... "At InsureMyTrip.com, we are,seeing noticeable changes in the ...
Cached Medicine News:Health News:Electronic Pillbox Helps Seniors Stick to Drug Regimens 2Health News:Electronic Pillbox Helps Seniors Stick to Drug Regimens 3Health News:MIPSolutions, Inc. Reduces Expense and Development Time Associated With Precious Metal Extraction 2Health News:International Diabetes Federation gives grant to Philippine diabetes education program 2Health News:Dutch Authorize Manufacture of Vaccinogen's New Cancer Vaccine; License Clears Path to European Production, Final FDA Trial 2Health News:InsureMyTrip.Com's Travel Insurance Tips for Protecting Your Summer Vacation 2Health News:InsureMyTrip.Com's Travel Insurance Tips for Protecting Your Summer Vacation 3
(Date:4/24/2015)... -- Hospira, Inc. (NYSE: HSP ), ... spoke about the importance of extrapolation in bringing biosimilars ... annual European Biosimilars Group conference in London ... publication of a pivotal white paper titled, "Why ... biosimilars." Speaking at the EGA conference, ...
(Date:4/23/2015)... , April 24, 2015  AbbVie (NYSE: ABBV ... Administration (FDA) has accepted its New Drug Application (NDA) ... two direct-acting antiviral treatment of ombitasvir, paritaprevir, ritonavir (OBV/PTV/r), ... of adults with chronic genotype 4 (GT4) hepatitis C ... first all-oral, interferon-free therapy being evaluated by the FDA ...
(Date:4/23/2015)... 23, 2015 Once again, BeaconMedaes is meeting ... to patient safety. BeaconMedaes, priority is to ... disease. The next generation Zone Valve Box ... are now mounted in the assembly, allowing for ease ... ceiling tiles potentially releasing dust spores and other bacteria ...
Breaking Medicine Technology:Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 2Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 3Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 4Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 5Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 6Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 7U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 3U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 4U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 5U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 6U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 7BeaconMedaes launches new Zone Valve Box Assembly 2
... The BIOM 3 (Binocular Indirect Ophthalmo-Microscope) incorporates ... microscope and enables a view of up to ... the BIOM 3 the eye may be rotated ... easily viewed. Even surgery through small pupils ...
... The Philips HeartStart Home Defibrillatorthe latest ... than 175,000 devices deployed, Philips is ... defibrillators on airplanes, and in airports, ... HeartStart Home Defibrillator is the first ...
... custom bars have a large body ... contacts (spaced 3 centimeters center-to-center) to ... repeated cleaning. Polarity indicators are molded ... handle fits our bar electrode styles. ...
... custom bars have a large body ... contacts (spaced 3 centimeters center-to-center) to ... repeated cleaning. Polarity indicators are molded ... handle fits our bar electrode styles. ...
Medicine Products: