Navigation Links
GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
Date:2/16/2010

Washington, DC Combining tamoxifen, the world's most prescribed breast cancer agent, with a compound found in the flowering plant feverfew may prevent initial or future resistance to the drug, say researchers at Georgetown Lombardi Comprehensive Cancer Center.

The finding, reported online in FASEB Feb. 12, provides new insight into the biological roots of that resistance, and also tests a novel way to get around it.

"A solution to tamoxifen resistance is sorely needed, and if a strategy like this can work, it would make a difference in our clinical care of breast cancer," says the study's lead investigator, Robert Clarke, PhD, DSc, a professor of oncology and physiology & biophysics at Lombardi, a part of Georgetown University Medical Center (GUMC). Clarke is also the interim director of GUMC's Biomedical Graduate Research Organization.

Clarke added that the purified research chemical they tested, parthenolide, a derivative of feverfew, is being tested by other scientists as treatment for a variety of cancers, as well as other health conditions. Feverfew has long been a staple of natural medicine, and is particularly known for its effects on headaches and arthritis. Latin for "fever reducer," feverfew is a common garden bush with small daisy-like flowers.

"The chemical clearly has potential, and we ought to be able to figure out fairly quickly if it can help solve tamoxifen's resistance problem," Clarke says.

Tamoxifen is a treatment of choice for breast cancer that is estrogen receptor positive (ER+), meaning that the hormone estrogen drives cancer growth. Most newly diagnosed breast cancers about 70 percent - fall into that category. But about half of these cancers do not initially respond to tamoxifen, which is designed to block the hormone from binding to the cell's protein receptor, and many patients that do respond are at risk for developing resistance and cancer relapse.

In this study, Clarke and a team of resear
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... (PRWEB) August 30, 2014 Jake W., 18, ... while in the Back2Basics Outdoor Adventures transition program ... finish high school so I can actually start on a ... and math, and I'm done.” , He has six months ... Back2Basics program. Most clients choose to continue on to the ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 “In 2013, a ... The Jones Firm says in a recently released article on ... person was injured in an auto accident every 12 minutes, ... minutes,” they continue. “Based on the 2013 statistics, between now ... vehicle collision.” , The threat of an auto accident is ...
(Date:8/30/2014)... Miami, FL (PRWEB) August 30, 2014 Zensah®, ... new Camo Compression Leg Sleeve . The camo sleeves ... Compression Leg Sleeve collection. The camo line includes classic ... purple and magenta. , Known as tibial stress syndrome, ... side of the lower leg. Swollen and irritated muscles, stress ...
(Date:8/30/2014)... Barton Associates, an industry leading physician, ... , announces a new office location in Keene, NH, ... headquartered in Peabody, MA, with additional staffing centers in ... Jupiter, FL. , Barton Associates made the decision to ... crisis affecting the United States, a crisis that will ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 What challenges ... What are the latest trends, concerns, and considerations? ... Dr. Ken Pendleton recently spoke with Woody Wommack, Southeast ... of current issues in football recruiting. Notably, Wommack ... younger athletes, changes that he thinks are coming as ...
Breaking Medicine News(10 mins):Health News:Startling Washington Auto Accident Statistics Discussed In Recently Released Article By The Jones Firm 2Health News:Camo Compression Leg Sleeves Provide Shin Splint Relief for Runners 2Health News:Barton Associates to Open a New Office Location in Keene, NH 2Health News:Woody Wommack of Rivals.com Discusses the World of NCAA Football Recruiting on SCI TV 2Health News:Woody Wommack of Rivals.com Discusses the World of NCAA Football Recruiting on SCI TV 3
... by Nancy Speck, PhD, professor of Cell and Developmental ... University of Pennsylvania, has discovered a molecular marker for ... in the developing embryo, which provides much-needed insights for ... in the bone marrow of adult mammals, generate all ...
... populations with a low prevalence of tuberculosis (TB), the ... in the U.S for the diagnosis of TB ... "We compared commercially available tests for latent tuberculosis ... LTBI prevalence," said James Mancuso, MD, DrPH, of the ...
... HealthDay Reporter , THURSDAY, Dec. 8 (HealthDay News) -- ... the known cosmetic and psychological advantages, a new study ... women with DCIS (ductal carcinoma in situ, an early ... Hershman, an associate professor of medicine and epidemiology at ...
... 8 (HealthDay News) -- New guidelines on treating so-called "latent" ... simplify the course of the therapy from about 9 months ... Control and Prevention. The new guidelines for public health ... expert opinion and the results of three clinical trials -- ...
... one of the coauthors of a new paper by a group ... for strong steps to be taken to control the global crisis ... of steps that need to be taken on a global scale ... a meeting the group held at the Banbury Conference Centre in ...
... Ga. A study that may help personalize pain ... at Georgia Health Sciences University. Dr. Cheedy Jaja, ... Nursing, has received a three-year National Institutes of Health ... play a role in metabolizing opioids could help physicians ...
Cached Medicine News:Health News:Penn study unlocks origins of blood stem cells 2Health News:Discordance among commercially-available diagnostics for latent TB infection 2Health News:Few Women Get Breast Reconstruction After Mastectomy: Study 2Health News:Few Women Get Breast Reconstruction After Mastectomy: Study 3Health News:CDC Issues New TB Treatment Guidelines 2Health News:New paper calls for strong steps to tackle antibiotic resistance 2Health News:Study probes genetic link to sickle cell pain management 2Health News:Study probes genetic link to sickle cell pain management 3Health News:Study probes genetic link to sickle cell pain management 4
(Date:8/29/2014)... , Aug. 29, 2014   Vittamed Corporation , a ... announced today that T. (Teo) Forcht Dagi , ... company,s Board of Directors. " Teo Forcht ... in neurosurgery, medical innovation and venture capital," said Remis ... delighted to add his clinical, strategic, and entrepreneurial expertise to ...
(Date:8/29/2014)... , Aug. 29, 2014 Diseases largely eradicated ... generation ago are returning. Measles was declared eliminated in ... 2014 as of August 15—the highest incidence in 20 ... health department declared whooping cough a problem of ... getting sick and dying from these preventable diseases—in part ...
(Date:8/29/2014)... /PRNewswire-iReach/ -- ChemImage will present a workshop focused on ... Forensic Science Society,s 22 nd International Symposium ... Australia .  Forensic Scientists will be in ... imaging can bring to examination procedures. ... Product Development at ChemImage, will host a workshop ...
Breaking Medicine Technology:Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3
... Tengion, Inc. (Nasdaq: TNGN ), a leader in ... as its President and Chief Executive Officer. Most recently, Mr. ... and Chief Executive Officer of CCS Medical, Inc., a company ... services for patients with chronic diseases, from 2008 until completion ...
... Accuray Incorporated (Nasdaq: ARAY ), the premier ... scheduled to present at the Oppenheimer Healthcare Conference in ... 1:00 p.m. EST/10:00 a.m. PST.  A ... from the Investor Relations page of the Company,s website ...
Cached Medicine Technology:Tengion Appoints John L. Miclot President and Chief Executive Officer 2Tengion Appoints John L. Miclot President and Chief Executive Officer 3Tengion Appoints John L. Miclot President and Chief Executive Officer 4
... Radiation Protection Goggles fit ... be used by the ... leaded glass, 1.0 mm ... provide increased scatter radiation ...
QualCraft™ Euro Lite has a molded nylon frame that fits most faces. Universal keyhole nose bridge fits narrow to average noses. Available with or without lead vinyl-lined side shields....
QualCraft™ Radiation Protection Eyewear providex maximum comfort and eye protection! Lenses made of 0.75 mm leaded glass. Side shields of 0.30 mm leaded acrylic help seal out scatter radiation ...
Qualcraft™ Radiation Readers, Wraparound Glasses. Protect yourself and have close-vision clarity....
Medicine Products: