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GUMBOS technology promises new drugs, electronic devices
Date:4/10/2013

based on in vitro measurements and are still currently under review.

Warner said that nanoGUMBOS technology allows scientists to produce new nanoparticles in a focused way such that these particles are produced for specific uses from the beginning. Some nanomaterials already use this approach. However, many nanoparticles developed so far for medical use, for instance, must be coated with other materials to provide the desired medicinal property. With GUMBOS technology, nanoparticles can have the desired property incorporated directly into the nanomaterial, he explained. For example, some nanoparticles are used as the drug delivery vehicle. "We can make nanoGUMBOS that are both the drug and the drug delivery vehicle," he said.

Warner cited as one example a newly developed nanoGUMBOS material, with a provisional patent application filed, that his team at LSU foresees as a lead in possible development of new anti-cancer drugs. Using in vitro studies, they are completing key research to better understand how nanoGUMBOS can be tuned to be selectively toxic to cancer cells and non-toxic to normal cells. More details are presented on this technology at this New Orleans ACS meeting.

"We have a material that is normally toxic to both cancer cells and normal cells," Warner explained. "If we introduce this material in vitro to normal cells, it kills them. Put them in the presence of cancer cells, it kills them. However, when we convert them to our GUMBOS, it only kills cancer cells. That's basically how it works."

In addition to biomedical applications, the materials also have potential uses in solar cells and as nanosensors and biomedical imaging reagents, Warner pointed out. Thus far, the scientists have made nanoGUMBOS in many shapes and sizes. For example, they can be spherical or shaped like rods or diamonds. Some nanoGUMBOS can fluoresce, or glow, while others are magnetic or conductive. Some can have multiple properties.


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Contact: Michael Bernstein
m_bernstein@acs.org
504-670-4707 (New Orleans Press Center, April 5-10)
202-872-6042

Michael Woods
m_woods@acs.org
504-670-4707 (New Orleans Press Center, April 5-10)
202-872-6293

American Chemical Society


Source:Eurekalert

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