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GSU study first to confirm long-term benefits of morphine treatment in infants
Date:11/3/2008

injection of morphine sulfate on the day of birth prior to inducing inflammation; another group received a saline injection instead. The groups were then raised identically and received identical procedures during a 60-day period. Rodents that received preemptive morphine behaved normally while those rats that received saline showed significant increases in pain sensitivity and were resistant to the pain relieving effects of morphine in adulthood.

"This tells us that morphine doesn't work very well in human children and adults that were formally in the NICU and didn't receive preemptive pain treatment, and since morphine is still the primary drug used to treat severe pain, this means that there is an entire subpopulation for which morphine doesn't work efficiently," Murphy said. "These results suggest that there are long-term benefits of providing all newborns with some sort of pain relieving medicine prior to the initiation of an invasive procedure."


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Contact: Martha Barker Koontz
mbarker@gsu.edu
404-413-5464
Georgia State University
Source:Eurekalert

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