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GSK Data Suggests Efficacy of Advair(R) and Serevent(R) is Not Impacted by Genetic Profile
Date:3/16/2008

ere treated for 16 weeks with either Advair or Serevent.

The results showed that there was no significant difference between any of the three genotype groups for the primary endpoint, morning peak expiratory flow rate, and all genotype groups showed sustained improvement on treatment with Advair or Serevent. There was also no difference between the improvement recorded for each of the three groups on the secondary endpoints of forced expiratory volume in 1 second (FEV1), symptom-free days or use of a rescue inhaler.

A sub-analysis of that trial was also presented today at the AAAAI meeting (abstract #509) by Harold Nelson, M.D., professor of medicine at National Jewish Medical and Research Center in Denver. Dr. Nelson's analysis found that the incidence of asthma exacerbations, defined as worsening asthma requiring ED-visit/hospitalization or any medication beyond protocol, did not differ by genetic profile, further suggesting that having a genetic variation in the beta-2 adrenergic receptor does not have an effect on response to Advair or Serevent.

Further research on the same group of patients (abstract #552) was also presented, examining more closely any link between genetic differences in the beta-2 adrenergic receptor gene and response to therapy. That trial looked at 11 different genetic polymorphisms or haplotypes on that gene and found that no single variation was associated with a differential response to Advair or Serevent.

Advair Diskus combines two medications in one device to help prevent and control asthma symptoms. Asthma causes inflammation (swelling in the airways) and airway constriction (the tightening of muscles that surround the airways), and Advair contains both an inhaled corticosteroid, fluticasone propionate, to reduce inflammation; and an inhaled long-acting bronchodilator, salmeterol, to help prevent and reduce airway constriction. Advair is for people who still have symptoms on another asthma controller, or who
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SOURCE GlaxoSmithKline
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