Navigation Links
GSK Data Suggests Efficacy of Advair(R) and Serevent(R) is Not Impacted by Genetic Profile
Date:3/16/2008

Study is the Largest Prospective Trial to Examine Asthma Outcomes Based on

Genetic Profile

RESEARCH TRIANGLE PARK, N.C. and PHILADELPHIA, March 16 /PRNewswire/ -- Data presented today by GlaxoSmithKline showed that genetic differences at the site of the beta-2 adrenergic receptor gene in asthma patients did not lead to different responses to Advair Diskus(R) (fluticasone propionate and salmeterol inhalation powder) or Serevent Diskus(R) (salmeterol xinofoate inhalation powder).

Past prospective clinical trials have found that the use of short-acting beta-agonists, such as albuterol, were linked to worse outcomes in patients with asthma with the Arg/Arg genotype of the beta-2 adrenergic receptor gene. In the research presented today, those patients with the Arg/Arg profile responded to Advair (the combination of an inhaled corticosteroid and a long-acting beta-agonist) or Serevent (a long-acting beta-agonist) treatment as well as those patients with the two other forms of the gene (Arg/Gly and Gly/Gly).

The data (abstract #554) was presented by Eugene R. Bleecker, M.D., a professor of medicine and co-director of the Center for Human Genomics at the Wake Forest University School of Medicine at the 2008 American Academy of Allergy, Asthma and Immunology annual meeting in Philadelphia.

"This study was the largest prospective study of the impact of genetic differences in the beta-2 adrenergic receptor on response to asthma therapy, and we were encouraged to see that patients with the Arg/Arg gene variation responded to Advair and Serevent therapy just as well as patients without that variation," said Dr. Bleecker. "This study is a large step forward in furthering our knowledge of the interplay between genetics and therapy in asthma."

The 544-patient trial evaluated three groups of patients: those with the Arg/Arg genotype, those with the Arg/Gly genotype and those with the Gly/Gly genotype. Patients w
'/>"/>

SOURCE GlaxoSmithKline
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Radiologist Leora Lanzkowsky Study Suggests ...
2. Newborn Screening Suggests Decline in Cystic Fibrosis
3. Study suggests antibiotic may prevent dreaded brain fever
4. Study Suggests Glucosamine Wont Ease Hip Arthritis
5. New Survey Suggests Confusion, Lack of Awareness About Heart Failure Could Be Preventing Critical Early Detection and Treatment
6. Study suggests new therapy for lung disease patients
7. New study suggests link between environmental toxins and early onset puberty in girls
8. Chemical Linked to Reproductive Harm Is Getting Into Babies From Shampoo, Lotion and Powder, New Study Suggests
9. Toxoplasma infection increases risk of schizophrenia, study suggests
10. Columbus Carried Syphilis From New World to Europe, Study Suggests
11. Research suggests new treatment suitable for all patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... issue of Experimental Biology and Medicine ... Gaskins and Paul Kenis in the Institute of ... University of Illinois Urbana-Champaign describe their recent work ... a variety of cell functions including energy metabolism, ... roles in regulating normal cellular behavior, redox status ...
(Date:4/17/2014)... team has created a new technology for modifying ... travel the body and selectively target cancer and ... devices that monitor and modify human physiology is ... no existing technology enabled bioengineers to build such ... respond in a customized fashion. , "The project ...
(Date:4/17/2014)... one in five infants in the United States annually ... several months after birth. Research into probiotic use for ... April 1, 2014 issue of the British Medical ... "Probiotics and Infant Colic," concluding that the use of ... did not reduce crying or fussing in infants ...
(Date:4/17/2014)... ward off depression among retirees, particularly among those who ... The Journals of Gerontology, Series B: Psychological Sciences ... Internet Use and Depression Among Retired Older Adults in ... report that Internet use reduced the probability of a ... , Late-life depression affects between 5 and 10 ...
(Date:4/17/2014)... general blood flow and alleviates muscle soreness after ... the University of Illinois at Chicago. , The ... the Archives of Physical Medicine and Rehabilitation ... in people who had not exercised, suggesting that ... level of physical activity. , Improved circulation and ...
Breaking Medicine News(10 mins):Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Building 'smart' cell-based therapies 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:Internet use may cut retirees' depression 2Health News:Massage therapy improves circulation, eases muscle soreness 2
... HILL In 2006, University of North Carolina at Chapel ... levels of LDL cholesterol are more likely to have Parkinson,s ... study could not answer the question of whether low LDL ... were diagnosed with Parkinsons, or if they developed low LDL ...
... Program Will Put Home Medical Equipment Providers out of,Business ... Million Seniors and,Disabled People in Kansas City Area, ... program for durable medical equipment (DME) scheduled to be,implemented ... 1,2008, will put many DME providers out of business ...
... April 4, 2008 Most people assume,that cancer is ... Cancer Society, healthy behaviors could prevent approximately half,of cancer ... all based on the,latest research, which people can make ... at its earliest, most curable stages., -- Don,t ...
... they might want to avoid theft of Social Security checks ... finds that senior citizens in Baltimore seem to avoid visiting ... because they want to stay home and make sure no ... help doctors get a better handle on fluctuations in when ...
... April 4, 2008 -- A promising vaccine being tested ... do -- clear beta-amyloid plaques from the brain -- ... learning and memory abilities, according to a University of ... the predominant pathology of Alzheimer,s disease -- beta-amyloid plaques ...
... ward off gastroenteritis, which causes vomiting and diarrhea in children ... and Drug Administration has approved a second oral vaccine for ... diarrhea in infants and children. , The Rotarix vaccine is ... from 6 to 24 weeks of age. , ...
Cached Medicine News:Health News:Pieces coming together in Parkinson's, cholesterol puzzle 2Health News:Medicare Bidding Program in Kansas City is Plagued by Problems, Says American Association for Homecare 2Health News:Medicare Bidding Program in Kansas City is Plagued by Problems, Says American Association for Homecare 3Health News:Ten Things You Can Do to Reduce Your Cancer Risk 2Health News:Ten Things You Can Do to Reduce Your Cancer Risk 3Health News:Ten Things You Can Do to Reduce Your Cancer Risk 4Health News:Ten Things You Can Do to Reduce Your Cancer Risk 5Health News:Seniors Avoid ER at Start of Month 2Health News:Seniors Avoid ER at Start of Month 3Health News:Alzheimer's vaccine clears plaque but has little effect on learning and memory impairment 2Health News:FDA OKs New Rotavirus Vaccine 2Health News:FDA OKs New Rotavirus Vaccine 3
(Date:1/15/2014)... Medical is very pleased to announce the appointment of Mr. ... Officer.  Mark was promoted from his current role of Chief ... facilities in Massachusetts , Mississippi ... in 2012 with 20+ years of broad-based operations, sales, engineering ...
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... Forecast – Worldwide Analysis ... Market Analysis Insulin ...
(Date:1/15/2014)... Mass. , Jan. 15, 2014  Zafgen, Inc., ... unmet needs of severely obese patients, today announced ... beloranib, a selective inhibitor of methionine aminopeptidase 2 ... severe form of genetic obesity.  These results showed ...
Breaking Medicine Technology:Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: