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GSK Data Suggests Efficacy of Advair(R) and Serevent(R) is Not Impacted by Genetic Profile
Date:3/16/2008

Study is the Largest Prospective Trial to Examine Asthma Outcomes Based on

Genetic Profile

RESEARCH TRIANGLE PARK, N.C. and PHILADELPHIA, March 16 /PRNewswire/ -- Data presented today by GlaxoSmithKline showed that genetic differences at the site of the beta-2 adrenergic receptor gene in asthma patients did not lead to different responses to Advair Diskus(R) (fluticasone propionate and salmeterol inhalation powder) or Serevent Diskus(R) (salmeterol xinofoate inhalation powder).

Past prospective clinical trials have found that the use of short-acting beta-agonists, such as albuterol, were linked to worse outcomes in patients with asthma with the Arg/Arg genotype of the beta-2 adrenergic receptor gene. In the research presented today, those patients with the Arg/Arg profile responded to Advair (the combination of an inhaled corticosteroid and a long-acting beta-agonist) or Serevent (a long-acting beta-agonist) treatment as well as those patients with the two other forms of the gene (Arg/Gly and Gly/Gly).

The data (abstract #554) was presented by Eugene R. Bleecker, M.D., a professor of medicine and co-director of the Center for Human Genomics at the Wake Forest University School of Medicine at the 2008 American Academy of Allergy, Asthma and Immunology annual meeting in Philadelphia.

"This study was the largest prospective study of the impact of genetic differences in the beta-2 adrenergic receptor on response to asthma therapy, and we were encouraged to see that patients with the Arg/Arg gene variation responded to Advair and Serevent therapy just as well as patients without that variation," said Dr. Bleecker. "This study is a large step forward in furthering our knowledge of the interplay between genetics and therapy in asthma."

The 544-patient trial evaluated three groups of patients: those with the Arg/Arg genotype, those with the Arg/Gly genotype and those with the Gly/Gly genotype. Patients w
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SOURCE GlaxoSmithKline
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