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GMCSF treatment associated with improved cognition in cancer patients
Date:6/22/2012

Tampa, FL (June 22, 2012) Growth factors shown to cure Alzheimer's disease in a mouse model and administered to cancer patients as part of their treatment regimen were linked to significant improvements in the patients' cognitive function following stem cell transplantation, a preliminary clinical study reports.

The findings by researchers at the USF Health Byrd Alzheimer's Institute and Moffitt Cancer Center are reported online in Brain Disorders & Therapy.

The retrospective study showed that cancer patients treated with granulocyte macrophage colony stimulating factor (GMCSF) plus granulocyte colony stimulating factor (GCSF) experienced greater improvement in memory and thinking than those treated with GCSF alone.

In the new study, the USF and Moffitt researchers investigated the link between GMCSF and cognitive functioning in humans for the first time, said principal investigator Huntington Potter, PhD, professor of molecular medicine at the USF Health Byrd Alzheimer's Institute. While the research looked at changes in cognition related to cancer treatment, it provided the basis for a new randomized controlled trial at the Byrd Alzheimer's Institute testing the safety and effectiveness of GMCSF (the drug sargramostim) in 40 patients with mild to moderate Alzheimer's disease.

GMCSF and GCSF, routinely administered to patients undergoing transplants to treat blood or bone marrow cancers, have a proven safety track record for this use. These growth, or colony stimulating, factors boost blood-forming stem cells circulating in the patient's own blood before the cells are harvested for autologous hematopoietic cell transplantation (HCT), speed the repopulation of cells depleted by chemotherapy or radiation, and/or fight infection in patients receiving bone marrow or blood stem cells from a donor.

Those involved in cancer research and clinical care are aware that problems with memory and concentration, referr
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Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3303
University of South Florida (USF Health)
Source:Eurekalert

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