Navigation Links
GEN reports on advances in DNA vaccine delivery and production
Date:9/1/2011

New Rochelle, NY, September 1, 2011Scientists involved in DNA vaccine research are currently focused on two major issues: the creation of effective delivery systems and the development of more efficient biomanufacturing strategies, reports Genetic Engineering & Biotechnology News (GEN). Top investigators in the field recently discussed these and other topics at a conference in San Diego entitled "DNA Vaccines: Building on Clinical Progress and Exploring New Targets," which was sponsored by the International Society of DNA Vaccines and organized by BioConferences International, a Mary Ann Liebert company, according to the September 1 issue of GEN. http://www.genengnews.com/issue/toc/0/

David Weiner, Ph.D., University of Pennsylvania professor and conference chair, noted that despite some early setbacks, DNA vaccine technology has advanced dramatically over the past few years and that therapies currently under evaluation are demonstrating the superb potential of plasmid-based vaccines. He emphasized that a range of novel vaccine methodologies have emerged, including new strategies for getting the plasmids into cells, increasing protein production once they are inside, and modifications of the vaccine proteins that increase their recognition and response by the immune system.

Some of the more promising delivery approaches include transdermal, needle-free patches, devices that transport the plasmids into the skin via air pressure, and electroporation, in which electrical pulses are used to temporarily open the cell membrane, allowing the plasmids easier access to the interior of cells.

On the manufacturing front, Philippe Ledent, Ph.D., process transfer and development manager at Eurogentec Biologics, explained that his company has faced major challenges scaling up the output of both protein and nucleic acid products. For plasmid production Eurogentec turned to fed-batch protocols for better growth control of the cultures, he said, adding that in a two-step process that was based on biomass expansion followed by plasmid DNA production, it was possible to increase fermentation yields 10-fold.

Tony Hitchcock, head of manufacturing technologies at RecipharmCobra Biologics, provided another approach to plasmid purification. The company's product line includes bacteria, animal cells, viruses, novel proteins, and antibodies. The overall process that Hitchcock sought to optimize was quite similar to that followed by Eurogentec: high density fermentation, followed by alkaline cell lysis, chromatographic purification, and final formulation.

Also covered in the GEN article are DNA vaccine production techniques used by Althea Technologies and VGXI.


'/>"/>

Contact: John Sterling
jsterling@genengnews.com
914-740-2196
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert

Related medicine news :

1. HPV Vaccination Rates Low Among Teen Girls, CDC Reports
2. NNI releases 4 workshop reports from the nanoEHS Series
3. Fast Food Is King of the Neighborhood, Study Reports
4. Vitamin D lower in NFL football players who suffered muscled injuries, study reports
5. Colon Cancer Death Rates Continue to Drop, CDC Reports
6. Patient reports of relatives cancer history often not accurate
7. Mayo Clinic reports new findings on noninvasive test for pancreatic cancer
8. GEN reports on novel noninvasive tests for early cancer detection
9. JAMA study reports on fatty liver disease in children and teens
10. Making temporary changes to brain could speed up learning, study reports
11. U.S. Reports Drop in AIDS-Related Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... 24, 2017 , ... The California State University Institute for Palliative Care ... or interested in palliative care education and research. The Symposium, “Innovate. Investigate. Educate: ... San Diego on Sept. 28 and 29, 2017, on the campus of California State ...
(Date:2/24/2017)... ... ... Indiana Fiber Network (IFN) President and CEO Kelly C. Dyer recently announced that ... Chairman of the Management Committee when IFN was originally formed in 2002 where he ... and development of the business plan. He became the first paid employee of ...
(Date:2/24/2017)... ... February 24, 2017 , ... Congratulations to Head ... division on February 12th. Ms. Esparza qualified into this prestigious status after ... held in Las Vegas, Nevada. Frida is one of approximately 25 gymnasts in ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... jointly issued a letter to withdraw previous guidance issued by the ... identity. The guidance issued in May 2016 by the Obama Administration came in ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rare Disease Report®, ... be participating in Rare Disease Day events, hosted by the Rare Disease Legislative ... Report, a website, weekly e-newsletter and quarterly publication, will be conducting interviews with ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)...  MiMedx Group, Inc. (NASDAQ: MDXG), the leading regenerative ... to develop and market advanced products and therapies for ... and Dental sectors of healthcare, today announced its record ... December 31, 2016. Full Year 2016 Highlights ... increase over full year 2015 revenue ...
(Date:2/23/2017)... On Wednesday, February 22, 2017, US markets saw ... sectors finished the trading sessions in green, four closed in ... indices were also mixed at the close of yesterday,s session. ... by 0.09%; the Dow Jones Industrial Average edged 0.16% higher, ... 2,362.82, down 0.11%. This Thursday morning, Stock-Callers.com looks at the ...
(Date:2/23/2017)... 2017 Tillotts Pharma is strengthening ... Berlin office was opened in January 2017 ... portfolio includes Entocort ® for the treatment of ... ulcerative colitis, and VistaPrep ® for bowel preparation ... pharmaceutical company focused on the treatment of gastrointestinal (GI) ...
Breaking Medicine Technology: