Navigation Links
Future hope for patients with breast cancers resistant to tamoxifen
Date:6/16/2008

Researchers have found a new family of therapeutic agents that interferes with the ability of estrogen to stimulate the growth of breast cancer cells. The results of the new study will be presented by Nicole Patterson at The Endocrine Society's 90th Annual Meeting in San Francisco.

The cell-based study suggests that a small-molecule therapeutic called TPBM and related compounds are likely to be effective against breast cancers that depend on estrogen to grow (called estrogen receptor-positive) but that are resistant to current therapies, team leader David Shapiro, PhD, said.

Shapiro, a biochemist at the University of Illinois at Urbana-Champaign, said at detection, about two-thirds of breast cancers are estrogen receptor-positive, and virtually all of these cancers become resistant over time to the breast cancer drug tamoxifen. In some tamoxifen-resistant tumors, tamoxifen begins to act like estrogen and can actually stimulate tumor growth, he explained.

Therefore, researchers are trying to find new ways to block resistance to drugs such as tamoxifen. Shapiro's team developed a technique to screen for chemical compounds that would inhibit the ability of estrogen and the estrogen receptor protein to bind to DNA and turn on gene expression in breast cancer cells.

"We targeted a different step in the pathway of estrogen action, one that is not targeted by current therapeutics," Shapiro said.

They then tested various agents in estrogen receptor-positive breast cancer cells in the laboratory. The team identified a family of compounds related to TPBM that Shapiro said inhibited the estrogen-dependent growth of breast cancer cells.

"TPBM is highly targeted and has little or no toxic effect on other cellsthose that don't depend on the estrogen receptor," Shapiro said. "Also important, these compounds are effective in breast cancer cells in which tamoxifen acts like estrogen."

Thus, these compounds might
'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cancer was one of the best things to happen to me ... but I worry about the future
2. Cancer was one of the best things to happen to me... but I worry about the future
3. Next 10 years crucial to ensure provision of clean water for future generations
4. Future of Behavioral Health Care for New Mexicos Youth Subject of Expert Panel Sponsored by ValueOptions(R)
5. Survivors of childhood Hodgkins lymphoma at higher risk of future health problems
6. Hodgkin Lymphoma Kids Face Greater Risk of Future Problems
7. New study shows sedentary high school girls are at significant risk for future osteoporosis
8. Invest in Your Future With a Spa Visit Today
9. NIDCR strategies for future scientific success
10. Former Senate Majority Leader, Princeton Economist Joust on Future of Health Care
11. AMICAS Focuses on the Future of Radiology IT at SIIM 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... 21, 2014 Over the past 39 ... in hundreds of emergency departments across the nation, from ... have been translated into an innovative suite of tools, ... deficiencies and enhance the patient experience. , NES ... staffing and management services for hospitals, announced the development ...
(Date:12/21/2014)... (PRWEB) December 21, 2014 Theme ... announced a new intro plugin for Final Cut Pro ... pictures, videos, logos, and more with absolute ease.” Said ... our users the tools needed to easily animate their ... Final Cut Pro X users to animate pictures, videos, ...
(Date:12/21/2014)... 21, 2014 CannabisClassifieds.com celebrates marijuana’s new legal ... only one of its kind, the site has provided its ... for 14 years running. It uniquely combines the benefits ... cannabis readily available to the masses. Assuring the potent ... golden ring of public approval. , Shane Chattin, ...
(Date:12/21/2014)... Concept Plus, LLC. a SDB and ... Fairfax, VA., today announced it has been recognized by ... which ranks the fastest growing government contracting small businesses by ... , This is the first year that Concept Plus, LLC., ... with a 95.92% compound annual growth rate. “For Concept Plus ...
(Date:12/20/2014)... 21, 2014 BambooIndustry.com is ... the business has announced its bamboo flooring promotion ... best material from certified suppliers, and offers the ... worldwide. In the current promotion, all customers can ... when they say they know BambooIndustry.com from press ...
Breaking Medicine News(10 mins):Health News:NES Health Launches Stipend Program for Emergency Physicians in Training to Financially Assist Emergency Department Doctors While They Learn 2Health News:Announcing a new plugin for Final Cut Pro X ProMotion from Pixel Film Studios. 2Health News:CannabisClassifieds.com Maintains its “Craigslist for Cannabis” Standing with Website Re-launch 2Health News:Concept Plus, LLC. Named One of Washington Technology’s Fast 50 2Health News:Eco-friendy Bamboo Flooring Manufacturer BambooIndustry.com Introduces Its Bamboo Flooring Promotion for 2015 2
... Incorporated debuts Generation Max(TM) as students start back to ... driver Rudd celebrates 900th career start, HACKETTSTOWN, N.J., Sept. ... start at the California Speedway on,Sept. 2nd - a milestone ... this race, Rudd,s #88 Snickers(R) Ford Fusion will be outfitted,with ...
... other racial minorities have sleep durations associated with increased ... unhealthy sleep patterns among minorities long sleep or ... to a study published in the September 1 issue ... Lauren Hale, PhD, assistant professor in the graduate program ...
... Aug. 31 A recent government report shows ... million. The uninsured often,have limited access to preventive ... increasing the chance that avoidable medical,conditions will send ... that,can help people get the medicines prescribed by ...
... TOLEDO, Ohio, Aug. 31 Manor Care, Inc. (NYSE:,HCR) ... October 17,2007 as the date for a special meeting ... Care by an affiliate of global private equity,firm The ... the record,date for the meeting. On August 6, 2007, ...
... disease outbreaks, experts warn , , FRIDAY, Aug. 31 (HealthDay ... been remarkably successful, virtually eliminating diseases like measles and ... be appearing in the public health system that would ... are readily available. , That,s because a sizable segment ...
... (Amex: ZTM ), today announced that Gregory Halpern ... Release he signed on August,20, 2007. Under the ... three months, salary plus unused vacation and would have ... In addition, under,the Agreement the Company would have received ...
Cached Medicine News:Health News:Video: Nutrition Comes to NASCAR 2Health News:Video: Nutrition Comes to NASCAR 3Health News:Minorities more likely to have sleep durations associated with increased mortality 2Health News:Minorities more likely to have sleep durations associated with increased mortality 3Health News:Manor Care, Inc. Announces Record Date for Special Stockholder Meeting 2Health News:Growing Number of U.S. Kids Not Getting Needed Vaccinations 2Health News:Growing Number of U.S. Kids Not Getting Needed Vaccinations 3Health News:Growing Number of U.S. Kids Not Getting Needed Vaccinations 4Health News:Z Trim Announces Revocation of Gregory Halpern Severence Agreement 2
(Date:12/17/2014)... 17, 2014 With advancements in neurological ... market is seeing new growth, according to Kalorama ... account for the majority of market volume, newer ... images, which are creating opportunities for more sophisticated applications. ... growing at a rate of 4%, with world ...
(Date:12/17/2014)... , The new ... of information concerning the biopharmaceutical Group,s national and international clinical ... to the recently launched institutional website that is receiving accolades ... by a new chapter in the fascinating story of Drug ... and panoramic hub on the world of clinical research, ranging ...
(Date:12/17/2014)... N.J. , Dec. 17, 2014  IGI Laboratories, ... today the closing of its offering of $125 million ... 2019 (the "Notes").  The Notes were offered and sold ... under the Securities Act of 1933, as amended (the ... a fixed rate of 3.75% per year, payable semiannually ...
Breaking Medicine Technology:Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4
... Nov. 12 A new treatment for autism appears ... S. Starr, MD, FAACAP, BCIA-EEG. , In ... characteristically common "u" EEG pattern reflecting impaired brain function, ... interaction, communication, speech and bonding. , ...
... MINNEAPOLIS/ST. PAUL, Nov. 12 /PRNewswire / -- ... for Integrative Oncology,s (SIO) Sixth International Conference in ... and safety of complementary and alternative medicine (CAM) ... Director, Hematology/Oncology at Children,s Hospitals and Clinics of ...
Cached Medicine Technology:New Treatment for Autism 'Holds Promise' 2New Treatment for Autism 'Holds Promise' 3New Research Shows Promise in Using Traditional Research Methods to Assess Efficacy of Complementary Therapies 2
The safePICO is a prebarcoded arterial sampler that helps you ensure patient and caregiver safety. SafePICO is part of 1st automatic, the worlds first automatic blood gas analysis system....
Measure SpO2 and tcpCO2 with a single sensor....
Two separate sensors provide continuous measurement of tcpO2/tcpCO2 and SpO2....
... components that comprise the SmartPill GI ... comprise the SmartPill GI Monitoring System: ... Receiver software and SmartPill MotiliGI software. ... indispensable parts of the SmartPill GI ...
Medicine Products: