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Future directions for landmark diabetes study in journal Diabetes Care
Date:1/28/2014

CLEVELAND The two most highly cited diabetes research trials Diabetes Control and Complications Trial (DCCT) and its follow-up study Epidemiology of Diabetes Interventions and Complications (EDIC) are marking their 30th anniversary. DCCT, which ran from 1982 to 1993, enrolled more than 1,400 adolescents and young adults with type 1 diabetes to evaluate if intensive control of diabetes could lower the risk of complications better than conventional control. EDIC launched in 1994 and continues to follow many patients from the original study.

This month, the journal Diabetes Care, published by the American Association of Diabetes, features a series of articles commemorating the anniversary of the groundbreaking studies. University Hospitals Rainbow Babies & Children's Hospital (UH Rainbow)/Case Western Reserve University School of Medicine together have constituted a lead center in DCCT/EDIC, the longest-running study funded by the National Institutes of Health.

Rose A. Gubitosi-Klug, MD, PhD, Interim Chief, Pediatric Endocrinology, Diabetes and Metabolism, UH Rainbow and Associate Professor of Pediatrics at Case Western Reserve School of Medicine, penned the series' summary and mapped out future directions for the research in the issue.

"DCCT/EDIC are landmark studies," said Dr. Gubitosi-Klug, who is Principal Investigator of the study's Clinical Coordinating Center at the School of Medicine and UH Rainbow. "They have set the standard of care for clinical management of type 1 diabetes, which has forever changed the course of its complications.

"The main message impacts the way we care for children with diabetes everyday: Earlier intervention is critical to prevent the complications of diabetes," said Dr. Gubitosi-Klug. "The message is clear: Controlling glucose levels is the major factor that can greatly lower the risk of the development and progression of the complications of type 1 diabetes, including eye and nerv
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Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals Case Medical Center
Source:Eurekalert

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