Navigation Links
Future directions for landmark diabetes study in journal Diabetes Care
Date:1/28/2014

CLEVELAND The two most highly cited diabetes research trials Diabetes Control and Complications Trial (DCCT) and its follow-up study Epidemiology of Diabetes Interventions and Complications (EDIC) are marking their 30th anniversary. DCCT, which ran from 1982 to 1993, enrolled more than 1,400 adolescents and young adults with type 1 diabetes to evaluate if intensive control of diabetes could lower the risk of complications better than conventional control. EDIC launched in 1994 and continues to follow many patients from the original study.

This month, the journal Diabetes Care, published by the American Association of Diabetes, features a series of articles commemorating the anniversary of the groundbreaking studies. University Hospitals Rainbow Babies & Children's Hospital (UH Rainbow)/Case Western Reserve University School of Medicine together have constituted a lead center in DCCT/EDIC, the longest-running study funded by the National Institutes of Health.

Rose A. Gubitosi-Klug, MD, PhD, Interim Chief, Pediatric Endocrinology, Diabetes and Metabolism, UH Rainbow and Associate Professor of Pediatrics at Case Western Reserve School of Medicine, penned the series' summary and mapped out future directions for the research in the issue.

"DCCT/EDIC are landmark studies," said Dr. Gubitosi-Klug, who is Principal Investigator of the study's Clinical Coordinating Center at the School of Medicine and UH Rainbow. "They have set the standard of care for clinical management of type 1 diabetes, which has forever changed the course of its complications.

"The main message impacts the way we care for children with diabetes everyday: Earlier intervention is critical to prevent the complications of diabetes," said Dr. Gubitosi-Klug. "The message is clear: Controlling glucose levels is the major factor that can greatly lower the risk of the development and progression of the complications of type 1 diabetes, including eye and nerve damage and heart disease."

Intensive management of diabetes includes multiple daily injections of insulin and careful blood glucose monitoring.

The doctor said one of the amazing aspects of the study is the high rate of participation by the research subjects, even 30 years later. "We find participation levels greater than 80 to 90 percent in many follow-up studies," she said. "The research participants believe they are contributing to a greater good that will help future patients."

In the coming years, Dr. Gubitosi-Klug said that DCCT/EDIC hopes to study several new areas, including defining the relative time course of the development of retinopathy, nephropathy and neuropathy, and whether rates of progression in one can shed light on the development of the other complications; establishing evidence-based frequency of screening for these complications; refining self-monitoring to learn more about the role of variability in glucose levels on outcomes; exploring the effects of glucose control on cognition and continuing to monitor the bottom line that intensive management prevents costly complications and is economically sage, among other initiatives.

Saul Genuth, MD, an endocrinologist at UH Case Medical Center and Professor of Medicine at Case Western Reserve School of Medicine, has co-chaired DCCT/EDIC since its inception.

An accompanying editorial in Diabetes Care, calls the study "the gift that keeps on giving." The complete anniversary issue is located at: http://care.diabetesjournals.org/site/misc/dcct.xhtml


'/>"/>

Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals Case Medical Center
Source:Eurekalert

Related medicine news :

1. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
2. Palpitations are predictive of future atrial fibrillation
3. Palpitations May Signal Future Heart Rhythm Problem
4. Global Energy Assessment identifies pathways to a sustainable energy future
5. Future reproductive outcomes for women who have had an ectopic pregnancy
6. Google Rolls Out Another Panda Algorithm Update – Small Businesses Plan for the Future of SEO
7. Rising Solar Engineering and Design Firm Enters 1.7 MW's in Connecticut ZREC Auction and Positions for Future Growth
8. UCLA School of Dentistry gets $5M from NIH to train future leaders in oral health research
9. Gel Shows Promise as Future Male Contraceptive
10. Drive toward a viable City of the Future
11. Engineering the smart health care of the future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ... March 30, 2017 , ... ... Academy of Nutrition and Dietetics (AND), will join nonprofit Seafood Nutrition Partnership (SNP) ... a live webinar designed to help nutrition educators and students inform consumers about ...
(Date:3/29/2017)... ... ... ARI Network Services, Inc. (NASDAQ: ARIS) announced today that Rhino Ag has ... of more than 650 U.S.-based dealers. Rhino, a member of the Alamo Group, offers ... and cutters, rear blades, post hole diggers, pasture renovators, tillers, disc mowers and box ...
(Date:3/29/2017)... ... ... is the main cause of hay fever in the United States, with an estimated 95 ... May to July each year; with the worst time for sufferers being June and July. ... http://www.haymax.us ) provide an effective defense against grass pollen; they are proven in independent studies ...
(Date:3/29/2017)... ... 30, 2017 , ... Sports Brand EXOUS Bodygear announced today a special sale ... for the remaining days of March, the price will be only $19.97. The EXOUS ... of just $10 (regular retail price $19.97). , The special promotional prices are to ...
(Date:3/29/2017)... ... 29, 2017 , ... Based on research from Guardian’s Fourth ... in trying to balance both short-term and long-term benefits demands. Are employers ... growing complexity, companies are finding that the short-term strategies used to control costs, ...
Breaking Medicine News(10 mins):
(Date:3/30/2017)... 30, 2017 Revenue Prospects by Product Type ... COPD) and Geography Respiratory Inhalers - our new study ... Respiratory Inhalers market heading? If you are involved in this sector ... shows you the potential revenues streams to 2027, assessing data, trends, ... ...
(Date:3/29/2017)... , March 29, 2017 Wound care devices ... healing of the wound. The industry mainly consists of ... for the treatment of wounds caused by mechanical, chemical, ... to diseases such as diabetes, skin related diseases, immunological ... Europe was the largest region in the ...
(Date:3/29/2017)... , March 29, 2017  BioSpecifics Technologies Corp. ... continues to develop collagenase based-therapies with a first ... marketed as XIAFLEX ®  in the U.S. and ... present a corporate overview at the upcoming 16 ... April 5, 2017 at 8:00 a.m. ET in ...
Breaking Medicine Technology: