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Further Upgrade to 2007 Financial Guidance Based on Strong Revenue Growth; VYVANSE Demand on Track
Date:11/1/2007

in other assets 0.6 0.2 1.3 3.0

Movement in deferred taxes (49.6) 6.0 (35.8) 5.0

Increase in accounts and notes

payable and other liabilities 96.1 40.1 103.8 94.9

(Decrease)/increase in deferred

revenue (42.9) (12.4) 45.6 (6.4)

Returns on investment from joint

venture 6.8 5.8 6.8 5.8

________ ________ ________ ________

Net cash provided by operating

activities(A) 123.7 82.1 408.1 342.9

________ ________ ________ ________

Unaudited US GAAP results for the three

and nine months to September 30, 2007

Consolidated Statements of Cash Flows

3 months 3 months 9 months 9 months

to to to to

September September September September

30, 30, 30, 30,

2007 2006 2007 2006

$M $M $M $M

________ ________ ________ ________

CASH FLOWS FROM INVESTING

ACTIVITIES:

Movements in short-term

investments - 1.4 55.8 6.9

Movements in restricted cash (2.4) (0.1) (12.0) 1.0

Purchases of subsidiary

undertakings, net of cash acquired - - (2,458.6) (0.8)

Expenses related to the New River

acquisition - - (60.4) -

Purchases of long
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SOURCE Shire plc
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