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Further Upgrade to 2007 Financial Guidance Based on Strong Revenue Growth; VYVANSE Demand on Track
Date:11/1/2007

________ ________ ________ ________

Earnings per share - basic

Income/(loss) from continuing

operations 6.4c 17.3c (308.8c) 33.5c

Gain on disposition of

discontinued operations - - - 8.1c

________ ________ ________ ________

Earnings/(loss) per ordinary share

- basic 6.4c 17.3c (308.8c) 41.6c

________ ________ ________ ________

Earnings per share - diluted

Income/(loss) from continuing

operations 6.3c 17.1c (308.8c) 33.2c

Gain on disposition of

discontinued operations - - - 8.0c

________ ________ ________ ________

Earnings/(loss) per ordinary share

- diluted 6.3c 17.1c (308.8c) 41.2c

________ ________ ________ ________

Earnings/(loss) per ADS - diluted 18.9c 51.3c (926.4c) 123.6c

________ ________ ________ ________

Weighted average number of shares:

Millions Millions Millions Millions

Basic 546.4 504.0 538.9 503.6

Diluted 554.7 509.1 538.9 508.7

________ ________ ________ ________

Unaudited US GAAP results for the three

and nine months to September 30, 2007

Consolidated Statements of Cash Flows

3 months 3 months 9 months 9 months

to to to to


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SOURCE Shire plc
Copyright©2007 PR Newswire.
All rights reserved

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