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Further Upgrade to 2007 Financial Guidance Based on Strong Revenue Growth; VYVANSE Demand on Track
Date:11/1/2007

$M $M $M $M

________ ________ ________ ________

Revenues:

Product sales 543.1 386.2 1,508.8 1,108.2

Royalties 61.9 60.4 185.4 181.8

Other revenues 3.7 2.8 17.6 9.5

________ _______ ________ _______

Total revenues 608.7 449.4 1,711.8 1,299.5

________ _______ ________ _______

Costs and expenses:

Cost of product sales(1) 79.5 61.7 213.3 185.3

Research and development 180.7 104.0 363.7 304.0

Selling, general and

administrative 286.7 214.9 753.5 594.2

Depreciation and amortization(1) 46.3 25.6 107.4 72.3

Integration costs - - 1.3 3.9

Gain on sale of product rights (7.1) (63.0) (12.1) (63.0)

In-process R&D charge - - 1,896.0 -

________ _______ ________ _______

Total operating expenses 586.1 343.2 3,323.1 1,096.7

________ _______ ________ _______

Operating income/(loss) 22.6 106.2 (1,611.3) 202.8

Interest income 8.0 12.6 42.7 36.8

Interest expense (18.0) (7.0) (53.8) (19.1)

Other (expenses)/income, net (1.6) 7.3 0.7 5.9

________ _______ ________ _______

Total other (expenses)/income, net (11.6) 12.9 (10.4) 23.6


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SOURCE Shire plc
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