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Further Upgrade to 2007 Financial Guidance Based on Strong Revenue Growth; VYVANSE Demand on Track
Date:11/1/2007

ing and commercial distribution in 34 countries worldwide.

3. Royalties

Royalty revenue increased to $61.9 million for the three months to September 30, 2007 (2006: $60.4 million).

Royalty Highlights

Royalties Royalty (1)

to Shire Growth

Product $M %

3TC 36.7 1%

ZEFFIX 10.2 10%

Other 15.0 3%

Total 61.9 2%

(1) Compared with 2006.

3TC - HIV infection and AIDS

Royalties from sales of 3TC for the three months to September 30, 2007 were $36.7 million, an increase of 1% compared to the same period in 2006 (2006: $36.5 million). The impact of foreign exchange movements has contributed 4% to the reported growth; excluding foreign exchange movements there has been a decline of 3% compared to the same period in 2006.

Shire receives royalties from GSK on worldwide 3TC sales. GSK's worldwide sales of 3TC for the three months to September 30, 2007 were $280 million, an increase of 2% compared to the same period in 2006 (2006: $275 million), but a decrease of approximately 3% on a constant exchange rate basis. While the nucleoside analogue market for HIV has continued to grow, competitive pressures within the market have increased leading to a decline in 3TC sales.

ZEFFIX - Chronic hepatitis B infection

Royalties from sales of ZEFFIX for the three months to September 30, 2007 were $10.2 million, an increase of 10% compared to the same period in 2006 (2006: $9.3 million). The impact of foreign exchange movements has contributed 6% to the reported growth; excluding foreign exchange movements there has been an increase of 4% compared to the same period in 2006.

Shire receives royalties from GSK on worldwide
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SOURCE Shire plc
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