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Further Upgrade to 2007 Financial Guidance Based on Strong Revenue Growth; VYVANSE Demand on Track
Date:11/1/2007

ce increase in January 2007 and wholesaler stocking. Shire also introduced an 8% price increase to ADDERALL XR on October 1, 2007.

Litigation proceedings concerning Shire's ADDERALL XR patents are ongoing. Further information on this litigation can be found in our filings with SEC, including our Annual Report on Form 10-K for the year to December 31, 2006.

VYVANSE - ADHD

VYVANSE's average share of the US ADHD prescription market during Q3 2007 was 2.4% following the launch of VYVANSE in July 2007, and market share had reached 3.7% by September 30, 2007. Product sales of $10.6 million for the three months to September 30, 2007 were net of $20.5 million sales deductions, primarily coupons, wholesaler discounts and rebates, which will trend over time to approximately 28% of product sales before sales deductions.

Launch stocks of $55.9 million (before sales deductions) were shipped to wholesalers in June 2007, with a further $1.9 million shipped in July 2007. Sales of launch stocks are being recognized into revenue as prescription demand is confirmed by IMS data. By September 30, 2007 these launch stocks had decreased to $36.9 million as patients purchased VYVANSE. Product sales of VYVANSE totaled $10.6 million comprising of $20.9 million of sales based on prescription demand, a further $10.2 million of sales from wholesaler restocking, net of sales deductions of $20.5 million. All initial launch stocks are expected to be recognized into revenue by the end of 2007.

DAYTRANA - ADHD

DAYTRANA's average share of the US ADHD market increased to 2.1% in Q3 2007 compared to 1.3% in Q3 2006. Increased market share together with 6% growth in the US ADHD market resulted in US prescriptions of DAYTRANA for the three months to September 30, 2007 being up 64% compared to the same period in 2006.

Product sales for the three months to September 30, 2007 were $9.4 million, a decrease of 5% compared to the same period in 2006 (2006: $9.9 million
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SOURCE Shire plc
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