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Further Upgrade to 2007 Financial Guidance Based on Strong Revenue Growth; VYVANSE Demand on Track
Date:11/1/2007

are in

Product $M Growth (2) (2) Q3 2007 (1)

Specialty Pharmaceuticals

ADDERALL XR 249.0 20% 3% 25%

VYVANSE 10.6(3) n/a n/a 2%

DAYTRANA 9.4 -5% 64% 2%

PENTASA 43.7 18% 2% 17%

LIALDA 16.3 n/a n/a 5%

FOSRENOL 28.7 135% 0% 9%

CARBATROL 19.3 -5% -5% 41%

XAGRID 16.8 26% n/a n/a

Human Genetic Therapies

REPLAGAL 40.7 26% n/a n/a

ELAPRASE 55.1 n/a n/a n/a

(1) Product specific prescription data is provided by IMS Health ("IMS"), a leading global provider of business intelligence for the pharmaceutical and healthcare industries. All other US market share data stated in the text below is also provided by IMS.

(2) Compared to Q3 2006.

(3) Comprised of $31.1 million from prescription demand and wholesaler stocking, net of sales deductions of $20.5 million.

Specialty Pharmaceuticals

ADDERALL XR - ADHD

ADDERALL XR had an average market share of 25% during Q3 2007 (2006: 26%). The fall in average market share followed the launch of VYVANSE in July 2007. US prescriptions for ADDERALL XR for the three months to September 30, 2007 increased by 3% compared to the same period in 2006 due to a 6% growth in the US ADHD market offset by the 1% fall in average market share.

Sales of ADDERALL XR for the three months to September 30, 2007 were $249.0 million, an increase of 20% compared to the same period in 2006 (2006: $207.6 million). Product sales growth was higher than prescription growth due primarily to a pri
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SOURCE Shire plc
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