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Further Upgrade to 2007 Financial Guidance Based on Strong Revenue Growth; VYVANSE Demand on Track
Date:11/1/2007

n-cash items that the Company's management believe are not indicative of the core performance of the business may not be excluded when preparing financial measures under US GAAP.

These non GAAP measures should not be considered in isolation from, as substitutes for, or superior to financial measures prepared in accordance with US GAAP.

The following are trademarks of Shire or companies within the Shire Group which are the subject of trademark registrations in certain territories:

ADDERALL XR(R) (mixed salts of a single-entity amphetamine)

ADDERALL(R) (mixed salts of a single-entity amphetamine)

CALCICHEW(R) range (calcium carbonate with or without vitamin D3)

CARBATROL(R) (carbamazepine) extended-release capsules

DAYTRANA(TM) (methylphenidate transdermal system)

ELAPRASE(R) (idursulfase)

FOSRENOL(R) (lanthanum carbonate)

INTUNIV(TM) (guanfacine) extended release

LIALDA(TM) (mesalamine)

MEZAVANT(R) (mesalazine)

REMINYL(R) (galantamine hydrobromide) (UK and Republic of Ireland)

REMINYL XL(TM) (galantamine hydrobromide) (UK and Republic of Ireland)

REPLAGAL(R) (agalsidase alfa)

SOLARAZE(R) (3%, gel diclofenac sodium (3%w/w))

VANIQA(R) (eflornithine hydrochloride)

VYVANSE(TM) (lisdexamfetamine dimesylate)

XAGRID(R) (anagrelide hydrochloride)

The following are trademarks of third parties referred to in this press release:

3TC (trademark of GlaxoSmithKline (GSK))

DYNEPO (trademark of Sanofi Aventis)

EQUETRO(TM) (a trademark Validus Pharmaceuticals, Inc.)

JUVISTA (trademark of Renovo)

PENTASA (trademark of Ferring)

RAZADYNE (trademark of Johnson & Johnson)

RAZADYNE ER (trademark of Johnson & Johnson)

REMINYL (trademark of Johnson & Johnson, excluding UK and Republic of

Ireland)

REMINYL XL (trademark of Johnson & Johnson, excluding UK and Republic of

Ireland)

ZEFFIX (trademark of GSK)
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SOURCE Shire plc
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