Navigation Links
Fungus uses copper detoxification as crafty defense mechanism
Date:3/14/2013

ubstances inside the macrophages is copper, a mineral the body needs for normal cognitive function and development, but also known to have antifungal properties. In the face of a pathogenic invasion of fungal spores, the macrophages begin concentrating more copper within their torture chamber as one of the body's antifungal weapons.

The Duke researchers found that lethal strains of C. neoformans have two ways of battling against the toxicity of the copper. First, the pathogen turns on genes that make proteins to protect it from copper toxicity, so even when exposed to the hostile copper environment in the macrophages, it survives.

But a second defense mechanism is also deployed. The fungus, sensing the copper-rich environment, triggers a response that shuts down the host's ability to pump more copper into the macrophages defusing this weapon in the immune system's arsenal.

"With these two mechanisms, C. neoformans can defend itself by sequestering the copper, and somehow communicate to the host macrophage, commanding that it shut down the copper pumps," Thiele said.

Thiele said studies are now focusing on how antifungal agents might thwart the pathogen's two defense systems. "The detoxification machinery might represent an effective drug target," Thiele said.


'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A new Achilles heel in fungus that causes dandruff
2. Scientists Shed Light on Fungus Behind Deadly Pneumonia Strain
3. New Topical Solution for fungal infection by Zeta Clear released to Cure Toenail and Fingernail fungus
4. New study detects deadly fungus in Southeast Asias amphibian trade
5. Be Present Welcomes Wanderlust Festival to Copper Mountain, Colorado
6. UCLA study to determine if copper surfaces can reduce hospital-acquired infections
7. New Rocky Mountain Architectural Hardware Series Combines Artisan-quality Style and Beauty with CuVerro® Antimicrobial Copper
8. Copper Vista Dental Care LLC in Arizona Announces the Opening of its Globe Dental Office
9. Copper depletion therapy keeps high-risk triple-negative breast cancer at bay
10. ASTER ELLIOTT, CNC a Nationwide Provider of Detoxification and Cleanse products, launches online Affiliate Program to promote and encourage healthy living
11. Scientists identify major source of cells defense against oxidative stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... ... July 06, 2015 , ... Seedstock today announced Pierre Sleiman, founder and CEO ... Annual Seedstock Sustainable Agriculture Conference – “Innovation and the Small Farmer” – to be ... University of California-San Diego, will explore solutions and methodologies that small farmers and entrepreneurs ...
(Date:7/6/2015)... (PRWEB) , ... July 06, 2015 , ... MD Now, ... Monday, July 6. The newly constructed urgent care center will serve residents and visitors ... In addition to being MD Now’s 22nd South Florida location, the new facility will ...
(Date:7/6/2015)... Georgia (PRWEB) , ... July 06, 2015 , ... ... has received nearly $400,000 in grant funds to support a three-year effort to ... , The work will be conducted in partnership with the Morehouse School of ...
(Date:7/6/2015)... ... July 06, 2015 , ... Promero, a leading cloud ... Software Unified IP contact center solution hosted by Promero. Randstad Technologies,a leading ... its future call center platform. , Promero will implement and manage the ...
(Date:7/6/2015)... (PRWEB) , ... July 06, 2015 , ... Thanks to ... Health and Hospice received the Music & Memory Certification for hospice patients and adult ... power of music not only to patients but also to their families and volunteers. ...
Breaking Medicine News(10 mins):Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 3Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 4Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 2Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 3Health News:Georgia State, Morehouse Partner To Tackle Diabetes, Heart Disease In Atlanta’s Minority Communities 2Health News:Aspect Software Unified IP, Hosted by Promero, Selected by Randstad Technologies 2Health News:Aspect Software Unified IP, Hosted by Promero, Selected by Randstad Technologies 3Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 2Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 3Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 4
... (HealthDay News) -- Socializing is a major part of the ... you suffer anxiety or feel tongue-tied at festive gatherings, here ... at Ryerson University in Toronto. First, some advice about ... open to conversation. Join an ongoing conversation, ideally with a ...
... shifted funds away from tobacco control programs may be ... study co-authored by San Francisco State University economist Sudip ... the levels recommended by the Centers for Disease Control ... times more than the cost of implementing the programs. ...
... of Medicine have homed in on potential differences in ... in an elaborate process from skin cells. The ... rare genetic condition that is associated with one of ... most people with the Timothy syndrome mutation have autism ...
... 25 (HealthDay News) -- Racism is similar to trauma ... adults in the United States, a new analysis finds. ... more than 18,000 black adults concluded that there are ... (psychological distress that is expressed as physical pain), interpersonal ...
... Black Friday, the kickoff to the holiday shopping season, is ... good deals, according to a marketing expert. "The more ... fun you,re likely to add to this holiday ritual," Sheri ... a university news release. Bridges offered a number of ...
... , WEDNESDAY, Nov. 23 (HealthDay News) -- A 36-year-old husband ... his trachea (windpipe) has received the world,s first artificial trachea ... Nov. 23 in The Lancet described the transplant ... Hospital in Stockholm, Sweden. Without the transplant, the authors ...
Cached Medicine News:Health News:Surviving Holiday Parties When You Have Social Anxiety 2Health News:States could see substantial savings with tobacco control programs 2Health News:Scientists identify defect in brain cell channel that may cause autism-like syndrome 2Health News:Scientists identify defect in brain cell channel that may cause autism-like syndrome 3Health News:Scientists identify defect in brain cell channel that may cause autism-like syndrome 4Health News:1st Artificial Windpipe Made With Stem Cells Seems Successful 2
(Date:7/6/2015)... July 6, 2015 Increase ... drive bioinformatics market in Germany ... released TechSci Research report, " Germany Bioinformatics Market Forecast ... Germany is projected to register a CAGR ... to witness tremendous growth on account of rising government ...
(Date:7/6/2015)... 6, 2015 Hologic, Inc. (NASDAQ: HOLX ... its financial results for the third quarter of fiscal ... closes.  In conjunction with the release, management will host ... Time. Interested participants may listen to the ... States ) or 719-325-4804 (for international callers) and ...
(Date:7/6/2015)... 2015 Moerae Matrix, a clinical stage ... target inflammation and fibrosis, today announced the appointment ... Chief Medical Officer. Dr. Bradford ... programs, which include a pipeline of therapies for ... Bill is an accomplished strategist and scientist with ...
Breaking Medicine Technology:Germany Bioinformatics Market to Grow at a CAGR Over 29% Through 2020 Says TechSci Research 2Germany Bioinformatics Market to Grow at a CAGR Over 29% Through 2020 Says TechSci Research 3Hologic to Announce Financial Results for the Third Quarter of Fiscal 2015 on Wednesday, July 29, 2015 2Moerae Matrix, Inc. (Moerae) Appoints Bill Bradford, M.D., PhD, as Chief Medical Officer 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: