Navigation Links
Fungus uses copper detoxification as crafty defense mechanism
Date:3/14/2013

DURHAM, NC A potentially lethal fungal infection appears to gain virulence by being able to anticipate and disarm a hostile immune attack in the lungs, according to findings by researchers at Duke Medicine.

Defense mechanisms used by the fungus Cryptococcus neoformans enable it to lead to fatal meningitis, which is one of the opportunistic infections often associated with death in HIV/AIDS patients, organ transplant recipients, diabetics and other immunosuppressed patients. In describing the complex process of how C. neoformans averts destruction in the lungs of mice, the Duke researchers have opened new options for drug development.

"Very few antifungal drugs are effective, so we need to identify the Achilles' heel of these fungal pathogens," said Dennis J. Thiele, PhD, the George Barth Geller Professor of Pharmacology and Cancer Biology at Duke University. Thiele is senior author of a study published March 13, 2013, in the journal Cell Host & Microbe. "With this research we may be closer to understanding how this fungal pathogen evades death in its host, and hopefully be closer to finding effective treatments."

Found in the environment, C. neoformans spores can be inhaled and cause infection, particularly when people have weakened immune systems. The Centers for Disease Control and Prevention estimates that worldwide, C. neoformans causes 1 million cases of meningitis a year among HIV/AIDS patients, with nearly 625,000 deaths.

Thiele and colleagues focused on the interplay between C. neoformans in the lungs of mice and the host's immune system, which mount an immediate attack against the pathogen.

The immune response is led by macrophages, which circulate in the blood stream and engulf invading microbes to destroy them. The macrophages are essentially tiny torture chambers for pathogens, using hostile conditions and toxic substances to kill invaders.

Among the s
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A new Achilles heel in fungus that causes dandruff
2. Scientists Shed Light on Fungus Behind Deadly Pneumonia Strain
3. New Topical Solution for fungal infection by Zeta Clear released to Cure Toenail and Fingernail fungus
4. New study detects deadly fungus in Southeast Asias amphibian trade
5. Be Present Welcomes Wanderlust Festival to Copper Mountain, Colorado
6. UCLA study to determine if copper surfaces can reduce hospital-acquired infections
7. New Rocky Mountain Architectural Hardware Series Combines Artisan-quality Style and Beauty with CuVerro® Antimicrobial Copper
8. Copper Vista Dental Care LLC in Arizona Announces the Opening of its Globe Dental Office
9. Copper depletion therapy keeps high-risk triple-negative breast cancer at bay
10. ASTER ELLIOTT, CNC a Nationwide Provider of Detoxification and Cleanse products, launches online Affiliate Program to promote and encourage healthy living
11. Scientists identify major source of cells defense against oxidative stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... (PRWEB) September 16, 2014 On September ... Danielle Strassle at the 2014 Buffalo Bills Alumni Foundation ... NY. , Bills legend and NFL Hall-of-Famer Joe ... the foundation in honoring Strassle for her dedication in ... goals and inspire others in her community to do ...
(Date:9/16/2014)... Austin, Texas (PRWEB) September 16, 2014 ... now be offering $0 shipping on all kettlebell purchases ... it easy for customers to get started with this ... of the Crossfit movement. The online store carries a ... education and free weekly workouts guides. , ...
(Date:9/16/2014)... 16, 2014 Antioch University has introduced ... in Clinical Mental Health Counseling from Antioch University ... of programs offered through Antioch’s online campus. The program ... 2015. , "Antioch University New England’s MA in Clinical ... field and a track record of preparing graduates for ...
(Date:9/16/2014)... 16, 2014 QuickMedical, a national ... supplies and a veteran-owned small business has officially ... Jant Pharmacal Corporation, Nipro Medical, and CP Medical ... its customers the best, most affordable medical equipment ... and in an effort to reach new medical ...
(Date:9/16/2014)... VA (PRWEB) September 16, 2014 The ... of Virginia this fall. Reflecting on what it means ... Expanding Community Vision investigates unique and thought-provoking topics. , ... to be inspired to look at their world differently. ... and set the stage for truly enlightening dialogue,” says ...
Breaking Medicine News(10 mins):Health News:The HearStrong Foundation and the Buffalo Bills Alumni Foundation Celebrated HearStrong Champion During 2014 Alumni Weekend 2Health News:Join the Kettlebell Movement - Kettlebell Kings Announces $0 Shipping on all Orders 2Health News:Antioch University Launches Online Master’s Degree Program in Clinical Mental Health Counseling 2Health News:Expanding Community Vision at the Science Museum of Virginia 2
... perfect example of a corporation that chose to, protect their ... piracy., -- Safwat Fahmy, SafeMedia Founder and ... ... Fla., April 8, 2008 Adamis Laboratories and,SafeMedia announced today that ...
... Corporation,(TSX:HAE), a specialty bio-therapeutics company developing high-value human,therapeutic proteins for commercialization, will hold ... Wednesday, April 9, 2008, Time: ... The National Club ... Toronto, Ontario ...
... Throw down your,mop and broom! Spring cleaning the house ... your body. Daily exposure to thousands of,toxins in the ... toxic load in the body that may result in ... ), "Ideally, you should cleanse with the seasons ...
... SEATTLE, April 8, 2008 The appearance of a ... a tune-up before other more serious,illnesses emerge, according to ... for Bastyr University., Worldwide, between 80% and 90% ... Simplex Virus or HSV-1), according to Dr. Sherman, who,is ...
... safety incidents cost the federal Medicare program $8.8 ... during 2004 through 2006, according to HealthGrades, fifth ... analysis of 41 million Medicare patient records found ... average, a 43 percent lower chance of experiencing ...
... EDT, WALTHAM, Mass., April 7, 2008 Repligen,Corporation ... President and,Chief Executive Officer, Walter C. Herlihy, Ph.D., will ... 2008 at 9:00 a.m. EDT, to provide,an update on ... by Thomson/CCBN and can be accessed via,Repligen,s website at ...
Cached Medicine News:Health News:Leading Life Sciences Company Installs SafeMedia's Network Security Management Appliance to Prevent Illegal Peer to Peer (P2P) File Sharing 2Health News:Media Invitation - Annual General and Special Meeting of Shareholders of Haemacure 2Health News:Spring Clean Your Body for the Perfect Cleanse 2Health News:A Cold Sore Is Often A Warning Sign of Deeper Health Issues, Expert Says 2Health News:Medical errors cost US $8.8B, result in 238,337 potentially preventable deaths: HealthGrades study 2Health News:Medical errors cost US $8.8B, result in 238,337 potentially preventable deaths: HealthGrades study 3Health News:Medical errors cost US $8.8B, result in 238,337 potentially preventable deaths: HealthGrades study 4Health News:Repligen Announces Conference Call to Update Orencia(R) Lawsuit 2Health News:Repligen Announces Conference Call to Update Orencia(R) Lawsuit 3
(Date:9/15/2014)... 2014 Research and Markets  has announced ... Market Research Report 2014" report to their offering. ... Report 2014 presents comprehensive data on paracetamol (acetaminophen) markets ... Asia , North America ... (acetaminophen) description, covers its application areas and related patterns. ...
(Date:9/15/2014)... , Sept. 15, 2014 Sysmex America, ... information systems technology, announced today an amended distributorship ... is for Sysmex reagents, controls and instruments including ... ™ , Sysmex XP-300™, XT-Series and XN-Series ... is effective immediately and continues until August 31, ...
(Date:9/15/2014)... , Sept. 15, 2014  Mariel Therapeutics, Inc., ... Protein-7 and its application in Osteoarthritis (OA) and Chronic ... experts to its newly formed scientific advisory board. The ... and scientific resource to the company as it continues ... "We are honored to have such leading experts in ...
Breaking Medicine Technology:Paracetamol (Acetaminophen) (CAS 103-90-2) Market Research Report 2014 2Paracetamol (Acetaminophen) (CAS 103-90-2) Market Research Report 2014 3Sysmex America, Inc. Renews LABSCO Distributorship 2Sysmex America, Inc. Renews LABSCO Distributorship 3Mariel Therapeutics Appoints World Leading Experts to Inaugural Scientific Advisory Board 2Mariel Therapeutics Appoints World Leading Experts to Inaugural Scientific Advisory Board 3Mariel Therapeutics Appoints World Leading Experts to Inaugural Scientific Advisory Board 4
... Mass., Aug. 25, 2011 Caliper Life Sciences, ... that its presentation at the Stifel Nicolaus Healthcare ... at 11:30 a.m. EDT.  Kevin Hrusovsky, President and ... on the company,s business. The live webcast can ...
... Aug. 25, 2011 PDI, Inc. (Nasdaq: ... promotional and commercialization services to health care companies, today ... Top 10 pharmaceutical company has been renewed for an ... PDI,s Shared Sales team beginning in September 2011 through ...
Cached Medicine Technology:PDI Announces Renewal of Engagement for 7th Consecutive Season 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: