Navigation Links
Fungal protein found to cross blood-brain barrier
Date:6/12/2014

over how C. neoformans breaches the blood-brain barrier, the investigators isolated candidate proteins from the cryptococcal cell surface. One was a previously uncharacterized metalloprotease that they named Mpr1. (A protease is an enzyme a specialized protein that promotes a chemical reaction; a metalloprotease contains a metal ion in this case zinc that is essential for its activity.) The M36 class of metalloproteases to which Mpr1 belongs is unique to fungi and does not occur in mammalian cells.

The investigators next artificially generated a strain of C. neoformans that lacked Mpr1 on the cell surface. Unlike the normal wild-type C. neoformans, the strain without Mpr1 could not cross an artificial model of the human blood-brain barrier.

They next took a strain of common baking yeast Saccharomyces cerevisiae that does not cross the blood-brain barrier and does not normally express Mpr1, and modified it to express Mpr1 on its cell surface. This strain then gained the ability to cross the blood-brain barrier model.

Investigators then infected mice with either the C. neoformans that lacked Mpr1 or the wild-type strain by injecting the organisms into their bloodstream. Comparing the brain pathology of mice 48 hours later, they found numerous cryptococci-filled cysts throughout the brain tissue of mice infected with the wild-type strain; these lesions were undetectable in those infected with the strain lacking Mpr1. In another experiment, after 37 days of being infected by the inhalation route, 85 percent of the mice exposed to the wild-type C. neoformans had died, while all of those given the fungus without Mpr1 were alive.

"Our studies are the first clear demonstration of a specific role for a fungal protease in invading the central nervous system," said Gelli. "The details of exactly how it crosses is an important new area under investigation."

New targeted therapie
'/>"/>

Contact: Carole Gan
carole.gan@ucdmc.ucdavis.edu
916-734-9047
University of California - Davis Health System
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Children failing asthma therapy may have severe asthma with fungal sensitization
2. Texas A&M biologists prove ZOLOFT packs potential to fight fungal meningitis
3. Cases Linked to Fungal Meningitis Now Number 328
4. Fungal Meningitis Outbreak Toll Now 28 Dead, 363 Sickened
5. Flesh-Eating Fungal Infection Can Follow Natural Disasters, Study Finds
6. New Topical Solution for fungal infection by Zeta Clear released to Cure Toenail and Fingernail fungus
7. Valley Fever Fungal Infection on Rise in Southwest
8. Combo Therapy Helps Knock Out Fungal Meningitis
9. Blood Test May Catch Deadly Fungal Infection Quickly
10. Study finds nearly 5 million asthmatics worldwide could benefit from antifungal therapy
11. New €6.1million project to develop new antifungal agents to treat resistant fungal infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... Mass., (PRWEB) September 01, 2014 BCC ... BLOOD-BRAIN BARRIER TECHNOLOGIES AND GLOBAL MARKETS , ... $21.8 million in 2013 and is expected to reach ... grow to $471.5 million by 2019, which is equivalent ... through 2019. The receptor-mediated transport (RMT) segment is forecasted ...
(Date:9/1/2014)... 2014 Parties involved in federally-filed Tylenol ... litigation’s status conference in September, where issues related to ... the Eastern District of Pennsylvania, Bernstein Liebhard LLP reports. ... posted on the Court’s website, the meeting is scheduled ... a.m. This is the latest of several Tylenol conferences ...
(Date:9/1/2014)... Ontraport , one of the latest ... to automate the small intricacies of managing an online ... prompting an investigative review. , “As a new ... all of the small details involved with running a ... “That’s why Ontraport has become so popular in this ...
(Date:9/1/2014)... AttorneyOne.com, a recognized authority on law, update ... the FDA on DePuy Synthes Craniomaxillofacial Distraction System ... 28, that specific lots of DePuy Synthes Craniomaxillofacial Distraction ... device may reverse directions after surgery. According to ... is an implant used to lengthen and/or stabilize the ...
(Date:9/1/2014)... (PRWEB) September 01, 2014 Beginning Tuesday, ... over 3,000 medical professionals and 10,000 consumers for the ... a 5-day gathering of the nation’s top medical professionals ... diseases or conditions. The week-long event contains more than ... scientific instruction available in the pain management field. , ...
Breaking Medicine News(10 mins):Health News:Global Market for Blood-Brain Barrier (BBB) Technology to Reach $471.5 Million in 2019; Highest CAGR Growth in Latin American Market With 10.5% 2Health News:Global Market for Blood-Brain Barrier (BBB) Technology to Reach $471.5 Million in 2019; Highest CAGR Growth in Latin American Market With 10.5% 3Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 2Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 3Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 4Health News:Ontraport: Review Exposes Automated Platform for Online Marketing Management 2Health News:DePuy Synthes Craniomaxillofacial Distraction System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 2Health News:DePuy Synthes Craniomaxillofacial Distraction System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 3Health News:Medical Marijuana Doctor Company Set to Present at Las Vegas Pain Week 2
... Yoplait Presents Concert Featuring Music Icon and Breast Cancer Survivor ... ... marks the milestone 10th,anniversary of Save Lids to Save Lives(R), Yoplait(R),s signature ... raise awareness,and funds for breast cancer. To date, Yoplait has donated more ...
... Merchant Gift ... Card, ... innovative prepaid debit programs, and Sodexo, a leading,foodservice and facilities management company ... the Esteem Pass(TM).,Esteem Pass is a filtered merchant prepaid debit card program ...
... Sept. 9 Autovan, LLC, a specialty,vehicle manufacturer ... use markets today announced a donation to Easter ... an Easter Seals, Foxworth,home in Rochester, New York., ... strong community advocate,for people with disabilities, joined Easter ...
... John Carrier announced today the addition of ... tools featuring a new line of ... sets __title__ KT Pro Tools]. These integrated ... first and Reid Supply has them ready ...
... territory by making their affordable health insurance products ... Quotebroker specializes in providing free health insurance quotes ... have difficulty obtaining affordable health insurance. They provide ... and associations across the state of Arizona for ...
... company, is thrilled to be included in Inc.,s 27th ... in the country. As the fastest growing company in ... to other healthcare staffing firms making the list it ... traveling healthcare staffing companies. It is the only company ...
Cached Medicine News:Health News:Yoplait(R) Celebrates 10th Anniversary of Save Lids to Save Lives(R) and Sustained Commitment to Fight Against Breast Cancer 2Health News:Yoplait(R) Celebrates 10th Anniversary of Save Lids to Save Lives(R) and Sustained Commitment to Fight Against Breast Cancer 3Health News:Yoplait(R) Celebrates 10th Anniversary of Save Lids to Save Lives(R) and Sustained Commitment to Fight Against Breast Cancer 4Health News:Sodexo Releases Innovative Prepaid Incentive Card Powered by eCommLink 2Health News:Sodexo Releases Innovative Prepaid Incentive Card Powered by eCommLink 3Health News:Autovan Donates Wheelchair-Accessible Van; Brings Greater Mobility to Facility in Rochester, New York 2Health News:Reid Supply Introduces Lifetime Warranty on New Line of Hand Tools 2Health News:Reid Supply Introduces Lifetime Warranty on New Line of Hand Tools 3Health News:Reid Supply Introduces Lifetime Warranty on New Line of Hand Tools 4Health News:Quotebroker Expands Territory by Offering Affordable Health Insurance Quotes to Arizona Residents 2Health News:Medical Solutions Ranks No. 472 in the 2008 Inc. 500 with Three-Year Sales Growth of 667.8% 2Health News:Medical Solutions Ranks No. 472 in the 2008 Inc. 500 with Three-Year Sales Growth of 667.8% 3Health News:Medical Solutions Ranks No. 472 in the 2008 Inc. 500 with Three-Year Sales Growth of 667.8% 4
(Date:8/29/2014)... 2014 Research and Markets has ... Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018" ... and Development Trend Forecast of Pharmaceutical Equipment Market in ... China,s pharmaceutical equipment industry in the ... landscape, and business performance of domestic major enterprises, as ...
(Date:8/29/2014)... -- According to the new research ... Reagent, Primer, Probe, Custom Oligos), End-User (Research, Pharmaceutical ... NGS, DNA, RNAi) - Global Forecast to 2019" ... is expected to reach $1,712.1 Million by 2019 ... CAGR of 9.8% from 2014 to 2019.. ...
(Date:8/29/2014)... 29, 2014 /PRNewswire-iReach/ -- ChemImage will present a workshop ... New Zealand Forensic Science Society,s 22 nd ... Adelaide, Australia .  Forensic Scientists will ... that hyperspectral imaging can bring to examination procedures. ... Director of Product Development at ChemImage, will host ...
Breaking Medicine Technology:Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3
... AMSTERDAM, May 31, 2011 Leading events organiser ... UBM), announced details of a new Logistics and Supply ... event dedicated to pharmaceutical contract services and outsourcing. ICSE ... Messe Frankfurt, Germany and is part of the world,s ...
... 2011 Volcano Corporation (NASDAQ: VOLC ), a ... guidance tools designed to enhance the treatment of coronary and ... in the Goldman Sachs 32nd Annual Global Healthcare Conference on ... 2:40 p.m., Pacific Daylight Time (5:40 p.m., Eastern Daylight Time). ...
Cached Medicine Technology:Logistics and Supply Chain Zone Introduced at ICSE 2011 Event 2Logistics and Supply Chain Zone Introduced at ICSE 2011 Event 3
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
... AliMed® Turnbuckle Ankle Orthosis enables ... torque at the ankle joint to ... The splint features a pair of ... and eversion/inversion simultaneously. Simply adjust the ...
Softsplint after bunion surgery. Hook-and-loop closure. Maintains hallux positioning and metatarsophalangeal alignment. Washable....
... As a prophylaxis for deep vein thrombosis, ... combination of graduated sequential compression and rapid ... formation by increasing venous ejection while producing ... System includes a pump with tube assembly ...
Medicine Products: