Navigation Links
Functional characteristics of antitumor T cells change w increasing time after therapeutic transfer
Date:3/21/2013

PHILADELPHIA Scientists have characterized how the functionality of genetically engineered T cells administered therapeutically to patients with melanoma changed over time. The data, which are published in Cancer Discovery, a journal of the American Association for Cancer Research, highlight the need for new strategies to sustain antitumor T cell functionality to increase the effectiveness of this immunotherapeutic approach.

Early clinical research has indicated that cell-based immunotherapies for cancer, in particular melanoma, have potential because patients treated with antitumor T cells frequently have an initial tumor response; however, those responses are often transient.

"The cell-based immunotherapy we utilized was that of genetically engineered T cells," said James R. Heath, Ph.D., Elizabeth W. Gilloon Professor of Chemistry at the California Institute of Technology in Pasadena, Calif. "This approach is the most widely applicable way to generate large numbers of highly functional antitumor T cells."

Different T cell functions are associated with distinct proteins. Heath and colleagues took a closer look at how genetically engineered T cells functioned or failed after being transferred into patients. To do this, they used a recently developed, multiplexed technology that gave them a high-resolution view of which function-associated proteins individual cells expressed.

The researchers analyzed T cells isolated from blood samples taken from three patients with melanoma at several time points after treatment with genetically engineered antimelanoma T cells. Each of the patients from whom samples were taken had exhibited a different level of response to the immunotherapy.

The most highly functioning genetically engineered antimelanoma T cells made up about 10 percent of the total population of transferred T cells.

"However, they dominated the immune response," Heath said. "In other words, 10 percent of the cells are putting out 100 times more protein than the other cells."

Although these highly functioning genetically engineered T cells had high tumor-killing capabilities when a patient first received them, those capabilities disappeared within two to three weeks.

"The genetically engineered T cells did recover their high functional capacity, but those functions no longer included tumor-killing," Heath said. "However, there was another population of T cells that emerged at around one month that did exhibit tumor-killing characteristics."

These new T cells appeared to be a byproduct, through a process known as epitope spreading, of the original genetically engineered, tumor-killing T cells the patient received, Heath explained. The researchers also discovered one potential cause for the transient response to T cell therapy. Results showed that as the patient's own immune system recovered, after its initial depletion prior to therapy, those recovering T cells appeared to inhibit the antitumor immune response.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. SiliconMesa Partners with DrFirst to Add E-prescribing and Medication Adherence Functionality to SiliconMesa EHR
2. Patient Prompt Announces Advanced Text Messaging Functionality at 2013 Annual AMGA in Orlando, Florida
3. Researchers Describe 1st Functional Cure of HIV in Baby
4. Functional electrical stimulation cycling promotes recovery in chronic spinal cord injury
5. Toddler functionally cured of HIV infection, NIH-supported investigators report
6. Researchers describe first functional HIV cure in an infant
7. Gut microbiota plays important role in functional bowel disorders
8. Does the functionality of your small finger determine your ability to master the violin?
9. Easy On Hold Reviews Latest Small Business Phone Systems for Music On Hold Ease and Functionality
10. Popular Medical Tourism Portal, myMEDholiday.com, Expands Its Functionality by Adding RSS Feeds
11. Noise protection - multifunctional and aesthetical
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... 29, 2016 , ... Regenerative Medicine Solutions (RMS) scored 94.8124 out ... earning them second place for Tampa’s Best Places to Work. They were ranked in ... a great accomplishment for our team,” says RMS Human Resources Manager Irene Miller. “We ...
(Date:4/29/2016)... San Rafael, CA (PRWEB) , ... April 29, 2016 , ... ... a week long softball camp from July 24th – 27th for girls aged 10-18. ... The camp is held at the beautiful Clark V. Whited Complex, one of the ...
(Date:4/29/2016)... ... 29, 2016 , ... HEALTHCAREfirst , the leading provider ... Deyta Analytics, recently announced the recipients of the fourth annual Hospice Honors, a ... from the caregiver’s point of view. The official list of recipients was unveiled ...
(Date:4/29/2016)... ... April 29, 2016 , ... Intellitec ... held May 16th to 18th at the Broward County Convention Center. The event ... to collaborate on best practices in public facility management. Intellitec Solutions will highlight ...
(Date:4/29/2016)... ... April 29, 2016 , ... Yisrayl Hawkins, Pastor and ... highlighting inconsistencies of adding BC and AD, saying it is time to set the ... After Christ. Yisrayl says this simply cannot possibly be true and offers explanation. , ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016 Elekta today announced ... will be the focal point of seven scientific presentations ... Society for Radiotherapy & Oncology, taking place April 29 ... state-of-the-art radiotherapy system and a high-field MRI scanner with ... the patient,s anatomy in real time. The MR-linac is ...
(Date:4/27/2016)... , April 27, 2016  Bayer Animal Health ... senior from the University of Florida College of ... Bayer Excellence in Communication Award (BECA). Brittany was ... were awarded a total of $70,000 in scholarship ... four years, Bayer has provided a total of ...
(Date:4/27/2016)... , April 27, 2016 ... USD 2.14 billion by 2022, according to a ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... affecting the efficiency and accuracy delivered by the ... demand for novel urinalysis instruments and consumables. For ...
Breaking Medicine Technology: