Navigation Links
Functional characteristics of antitumor T cells change w increasing time after therapeutic transfer
Date:3/21/2013

PHILADELPHIA Scientists have characterized how the functionality of genetically engineered T cells administered therapeutically to patients with melanoma changed over time. The data, which are published in Cancer Discovery, a journal of the American Association for Cancer Research, highlight the need for new strategies to sustain antitumor T cell functionality to increase the effectiveness of this immunotherapeutic approach.

Early clinical research has indicated that cell-based immunotherapies for cancer, in particular melanoma, have potential because patients treated with antitumor T cells frequently have an initial tumor response; however, those responses are often transient.

"The cell-based immunotherapy we utilized was that of genetically engineered T cells," said James R. Heath, Ph.D., Elizabeth W. Gilloon Professor of Chemistry at the California Institute of Technology in Pasadena, Calif. "This approach is the most widely applicable way to generate large numbers of highly functional antitumor T cells."

Different T cell functions are associated with distinct proteins. Heath and colleagues took a closer look at how genetically engineered T cells functioned or failed after being transferred into patients. To do this, they used a recently developed, multiplexed technology that gave them a high-resolution view of which function-associated proteins individual cells expressed.

The researchers analyzed T cells isolated from blood samples taken from three patients with melanoma at several time points after treatment with genetically engineered antimelanoma T cells. Each of the patients from whom samples were taken had exhibited a different level of response to the immunotherapy.

The most highly functioning genetically engineered antimelanoma T cells made up about 10 percent of the total population of transferred T cells.

"However, they dominated the immune response," Heath said. "In other words, 10 percent of the cells are putting out 100 times more protein than the other cells."

Although these highly functioning genetically engineered T cells had high tumor-killing capabilities when a patient first received them, those capabilities disappeared within two to three weeks.

"The genetically engineered T cells did recover their high functional capacity, but those functions no longer included tumor-killing," Heath said. "However, there was another population of T cells that emerged at around one month that did exhibit tumor-killing characteristics."

These new T cells appeared to be a byproduct, through a process known as epitope spreading, of the original genetically engineered, tumor-killing T cells the patient received, Heath explained. The researchers also discovered one potential cause for the transient response to T cell therapy. Results showed that as the patient's own immune system recovered, after its initial depletion prior to therapy, those recovering T cells appeared to inhibit the antitumor immune response.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. SiliconMesa Partners with DrFirst to Add E-prescribing and Medication Adherence Functionality to SiliconMesa EHR
2. Patient Prompt Announces Advanced Text Messaging Functionality at 2013 Annual AMGA in Orlando, Florida
3. Researchers Describe 1st Functional Cure of HIV in Baby
4. Functional electrical stimulation cycling promotes recovery in chronic spinal cord injury
5. Toddler functionally cured of HIV infection, NIH-supported investigators report
6. Researchers describe first functional HIV cure in an infant
7. Gut microbiota plays important role in functional bowel disorders
8. Does the functionality of your small finger determine your ability to master the violin?
9. Easy On Hold Reviews Latest Small Business Phone Systems for Music On Hold Ease and Functionality
10. Popular Medical Tourism Portal, myMEDholiday.com, Expands Its Functionality by Adding RSS Feeds
11. Noise protection - multifunctional and aesthetical
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... Center for Autism ... diagnosed with autism spectrum disorder (ASD). Beginning Jan. 1, 2016, Medicaid is covering ... analysis (ABA) is key to providing effective treatment for individuals with ASD. Now, ...
(Date:2/9/2016)... ... February 09, 2016 , ... A ... fee schedule rates and Medicare rates for a variety of medical services in ... Evaluation of the 2015 Fee Schedule Rates in Illinois, are professional ...
(Date:2/9/2016)... ... 2016 , ... Establishment Labs, a global breast implant and medical technology company, ... of Directors. , “We are honored to welcome David to our Board ... Jose Chacon Quiros, CEO of Establishment Labs. "David’s knowledge and experience will be invaluable ...
(Date:2/9/2016)... ... 2016 , ... Dr. Rassouli, cosmetic dentist in Orange County , is ... popular cosmetic procedures in dentistry today, but the cost often leads to patients looking ... of teeth whitening-related damage. For a limited time, Dr. Rassouli is offering this special ...
(Date:2/9/2016)... ... February 09, 2016 , ... Two renowned photographers, Robert Caplin ... photographic adventure on the island, June 14-19, 2016, hosted by Four Seasons Resort Maui ... , After a successful debut in 2015, the Maui Photo Expedition workshop ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016  The Parenteral Drug ... professionals developing and manufacturing sterile drug products, today ... Regulatory Guidance Comparison – With link to Comparison ... issued by the U.S. FDA, the EU, the ... --> --> ...
(Date:2/8/2016)... , Feb.8, 2016 Cardiovascular Surgery ... Summary GlobalData,s Medical Devices sector report, "Cardiovascular ... provides an overview of Cardiovascular Surgery Devices currently ... --> The report provides comprehensive information ... the products at various stages of development. The ...
(Date:2/8/2016)... and FAIRFIELD, N.J. , ... and Medimetriks Pharmaceuticals, Inc. (Medimetriks) today announced that they ... development and commercialization rights for OPA-15406 in the U.S. ... also provides manufacturing rights.  OPA-15406 is a topical, non-steroidal ... atopic dermatitis. --> --> ...
Breaking Medicine Technology: