Navigation Links
Full-Body Scans May Help the Highly Cancer-Prone

People with Li-Fraumeni syndrome have a 90% chance of malignancy by age 60

FRIDAY, March 21 (HealthDay News) -- Full-body PET/CT scans identified unsuspected, treatable tumors in three of 15 patients with a rare genetic condition that greatly increases the risk of cancer, say researchers at the Dana-Farber Cancer Institute in Boston.

In most people with the condition, called Li-Fraumeni syndrome (LFS), a mutation in the TP53 tumor suppressor gene makes them highly susceptible to a variety of cancers from an early age. It's estimated that people with LFS have a 50 percent chance of developing cancer by age 30, and a 90 percent chance by age 60. A person with LFS who has survived one cancer is at high risk for developing another cancer. Currently, there are no recommended cancer screening tests for LFS patients.

The Dana-Farber team said their results suggest that periodic PET/CT scans, together with physical exams, may help detect tumors at a curable stage. However, larger studies are needed to determine whether such screening leads to increased survival and whether the risks outweigh the benefits, the researchers added.

"We need to be cautious, and we shouldn't say that every patient with the syndrome should have a PET/CT examination. But the study showed some interesting findings that justify a larger, international study in these patients," Dr. Annick Van Den Abbeele, clinical director of radiology and director of nuclear medicine/positron emission tomography, said in a prepared statement.

The study, published in the March 19 issue of the Journal of the American Medical Association, included 15 healthy adult members of families with a history of LFS. None of the participants had been diagnosed with cancer in the previous five years.

The PET/CT scans detected thyroid cancer in a 31-year-old breast cancer survivor and a 48-year-old survivor of breast cancer and a childhood scarcoma. The scans also found a tumor at the junction of the stomach and esophagus in a 36-year-old man with no history of cancer. All three patients received potentially curative treatments.

"We decided to study this in the adult LFS population because PET/CT scanning is used in the care of many of the type cancers that occur in LFS. Both LFS families and physicians have been frustrated by the lack of information for families with a rare and burdensome condition," study senior author Dr. Judy Garber, director of Dana-Farber's Cancer Risk and Prevention Clinic, said in a prepared statement.

More information

The U.S. National Library of Medicine has more about Li-Fraumeni syndrome.

-- Robert Preidt

SOURCE: Dana-Farber Cancer Institute, news release, March 18, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scans spot hidden tumors in rare cancer syndrome
2. SCAI Applauds CMS Decision to Continue Coverage of Cardiac CT Scans
3. Brain Scans Let Computer Read Visual Activity
4. PET Scans Best for Measuring Response to Sarcoma Treatment
5. CT Scans Catch More Clots in Lungs
6. Hazards of CT scans overstated
7. Statement by MITA Vice President Andrew Whitman on the Benefits of CT Scans Relative to Radiation Dose Risks
8. Rise in CT Scans Poses Cancer Risk
9. PET Scans Could Boost Lung Cancer Diagnosis
10. Obesity Keeps Patients From Needed CT Scans After Surgery
11. CT scans to determine heart disease in the emergency room
Post Your Comments:
Related Image:
Full-Body Scans May Help the Highly Cancer-Prone
(Date:11/25/2015)... ... November 25, 2015 , ... The holiday ... dish and pleasing the palates of attendees is of the utmost importance. Whether ... a seasonal get-together, give these recipes a try this holiday season. , Turkey ...
(Date:11/25/2015)... Nairobi (PRWEB) , ... November 26, 2015 , ... ... African Union Commission (AUC), European Union (EU), ANDI Pan African Centres of Excellence, ... Nations Office in Nairobi (UNON) for the opening of the 5th African Network ...
(Date:11/25/2015)... ... 25, 2015 , ... Dental professionals who would like to become more proficient ... attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. Courses will be held ... the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and Dr. D’Orazio are proud ...
(Date:11/25/2015)... ... 2015 , ... Smiles by Stevens is pleased to announce the ... While many patients are aware of the benefits of Botox® in the treatment of ... suffering with discomfort, soreness, and pain as a result of Jaw Tension, TMJ (temporo-mandibular ...
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, I saw a ... “I thought there had to be a convenient and comfortable way to protect them ... enables disabled individuals to safely travel during cold or inclement weather. In doing so, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... -- ) has announced the ... Viscosity Drugs" report to their offering. ... of the "Self Administration of High Viscosity ... Research and Markets ( ) has ... of High Viscosity Drugs" report to their ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Cell Surface Marker Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
(Date:11/25/2015)... , Nov. 25, 2015  Amgen (NASDAQ: AMGN ... Application (BLA) with the United States ... 501, a biosimilar candidate to Humira ® (adalimumab). ... application submitted to the FDA and represents Amgen,s first ... Sean E. Harper , M.D., executive vice president of ...
Breaking Medicine Technology: