Navigation Links
Fugitive cancer cells can be blocked by stopping blood cells that aid them
Date:3/6/2008

Cancer cells get a helping hand from platelets, specialized blood cells involved in clotting. Platelets shelter and feed tumor cells that stray into the bloodstream, making it easier for cancer to spread, or metastasize. Research at Washington University School of Medicine in St. Louis suggests that inactivating platelets could slow down or prevent metastasis.

In advance online publication in the Journal of Cellular Biochemistry, the scientists report that a combination of two platelet inhibitors reduced the number and size of breast cancer or melanoma tumors that grew in the bones of laboratory mice.

One of the drugs was aspirin, a widely used inhibitor of platelet clotting. The other was an experimental drug, APT102, which also prevents platelet clotting, but by a different mechanism. Both drugs were needed to reduce bone tumors.

"Past research has shown that tumor cells activate platelets and that mice with defective platelets have significantly fewer metastases," says Katherine Weilbaecher, M.D., assistant professor of medicine and of cell biology and physiology. "We also know that platelets have several traits that can aid tumor cells, and we are working to break up that potentially lethal partnership."

Metastasis of cancer cells to sites away from the main tumor can cause pain and other symptoms and greatly increases the likelihood a patient will die of the disease. In fact, more than 90 percent of cancer deaths are the result of metastasis, which is difficult to control with current therapies.

Cancer cells that leave the primary tumor and circulate in the bloodstream can readily take advantage of platelets they encounter. The circulating tumor cells secrete factors that make platelets stick together, creating a shield of platelets that protects cancer cells from immune attack. In addition, platelets release growth factors that help tumor cells survive, and platelets' capacity to stick to particular sites enab
'/>"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Colonoscopy Used to Identify and Remove Flat Colon Lesions: Flat Colon Lesions More Common and More Likely to Be Cancer According to JAMA Study
2. MultiVu Video Feed: New National Colorectal Cancer Screening Guidelines Issued by the American Cancer Society
3. Sharing Miracles Television Program to Feature Mountain Climber and Cancer Survivor Sean Swarner
4. ASGE Re-Launches Colon Cancer Awareness Web Site www.Screen4coloncancer.Org for National Colorectal Cancer Awareness Month
5. Cell recycling protects tumor cells from anti-cancer therapy
6. Drugs like aspirin could reduce breast cancer and help existing sufferers
7. Beverly Hills Executive Competes as a Rodeo Cowboy to Fund Cancer Research
8. Estrogen Levels in Blood Predict Breast Cancers Return
9. New guidelines update recommendations on colorectal cancer screening
10. Patrick Swayzes Diagnosis With Pancreatic Cancer: a Statement From the Pancreatic Cancer Action Network
11. New Guidelines Update Recommendations on Colorectal Cancer Screening
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... The Healthy Skin Care Journal, a ... skin care products, recently announced its launch. Located on ... wide variety of articles, tips, and evaluations about popular ... alternatives. , According to Emily Lataille, the website’s main ... thoroughly researched reviews, tips for the skin, and information ...
(Date:11/24/2014)... November 24, 2014 Volpara Solutions ... 1.2 at the 100th Annual Meeting of the ... 5, 2014 (RSNA Booth 1752 – South Hall). ... VolparaAnalytics and the rest of its innovative suite ... VolparaDoseRT, which enable personalized measurements of volumetric density, ...
(Date:11/24/2014)... UK (PRWEB) November 24, 2014 ... Massaggi , London's pre-eminent pain-relief service and massage ... Emmett Sports Massage (ESM). This newest sports ... , The key difference between traditional sports massage ... to access the body's very own "reset button,” ...
(Date:11/24/2014)... York (PRWEB) November 24, 2014 The ... by the Family and Children's Association to ... as soap, shampoo, mouthwash and other such items.The Association's ... who are home bound, living in nursing homes, assisted ... to greatly enhance the well being of seniors throughout ...
(Date:11/24/2014)... The typical American diet includes foods ... Consistently consuming a diet high in calories and carbohydrates ... fat that typically accumulate around the internal organs exposing ... head in the form of love handles, beer bellies ... decision to rid themselves of the burden of embarrassing, ...
Breaking Medicine News(10 mins):Health News:Skin Care Advice Blog The Healthy Skin Care Journal Now Accessible to the Public 2Health News:Volpara Solutions to Launch VolparaAnalytics 1.2 at RSNA 2Health News:Volpara Solutions to Launch VolparaAnalytics 1.2 at RSNA 3Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 2Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 3Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 2Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 3Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 2Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 3Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 4
... Corporation,announced today that its reorganization agreement with several ... Under the terms of the proposed reorganization agreement ... private placement of common,shares for gross proceeds of ... within 14 days of the mailing of the ...
... could lead to more targeted prevention efforts, researcher says , , ... of choice for Hispanics in the United States, a new ... we can identify a type of beverage that is more ... policies can be developed to target that beverage and that ...
... the HiArt treatment system for advanced radiation therapy, announced today that ... manufacturer Chengdu Twin Peak Accelerator Technology Inc., based in Chengdu, China. ... ... 4, 2008 -- A linear accelerator (linac) is a key ...
... Conn., Nov. 4 VION,PHARMACEUTICALS, INC. (OTC Bulletin Board: ... Thursday, November 6, 2008 to,discuss its 2008 third quarter ... a.m. Eastern Time., To participate in the conference ... for international callers), at least 15 minutes,before the start ...
... new medication is,available to treat dogs with Cushing,s disease, ... managing the disease, according to a veterinarian,at Kansas State ... associate professor of clinical sciences, said a,new drug called ... but veterinarians may obtain the medication if they decide,it ...
... Proactive measures can reduce hip fracture rates by an average ... -- among those at risk, according to a study conducted ... on November 3 by The Journal of Bone & ... study of its kind, the five-year study tracked more than ...
Cached Medicine News:Health News:Study Shows Hispanics Prefer Beer 2Health News: TomoTherapy Completes Acquisition of Linear Accelerator Manufacturer in China 2Health News:Vion Updates Conference Call Information 2Health News:Vion Updates Conference Call Information 3Health News:K-State Veterinarian Discusses Treating Dogs With Cushing's Disease 2Health News:Healthy bones program reduces hip fractures by 37 percent 2
(Date:11/24/2014)... 24, 2014  GlySens Incorporated announced today that it ... from the National Institute of Diabetes and Digestive and ... of Health (NIH).  The grant is intended to support ... long term implantable glucose monitoring system.  Final preparations for ... expected to begin before the end of 2014. ...
(Date:11/23/2014)... Calif. , Nov. 23, 2014 Anthera ... that Paul F. Truex , President and Chief ... 2014 Annual Piper Jaffray Healthcare Conference. ... , at the Palace Hotel in New ... Pharmaceuticals Anthera Pharmaceuticals is a biopharmaceutical company ...
(Date:11/22/2014)... , 21 de noviembre de 2014 /PRNewswire/ ... ensayos clínicos externalizados y tecnologías eClinical, ha indicado ... de ,seguimiento inteligente, para el seguimiento basado en ... inteligente amplía el concepto del seguimiento basado en ... de las visitas de seguimiento o cambio de ...
Breaking Medicine Technology:GlySens Incorporated Awarded $2 Million Grant from the National Institutes of Health 2Anthera Pharmaceuticals to Present at Annual Piper Jaffray Healthcare Conference 2El 'seguimiento inteligente' consigue un excelente momento 2El 'seguimiento inteligente' consigue un excelente momento 3
... April 12, 2011 Zimmer Holdings, Inc. (NYSE: ... sales and earnings conference call will be broadcast live over ... Eastern Time.  A news release detailing the quarterly results will ... of the conference call. The live audio ...
... /PRNewswire-Asia-FirstCall/ -- China Botanic Pharmaceutical Inc. (AMEX: ... a developer, manufacturer and distributor of botanical products, ... today announced that its wholly owned subsidiary, Harbin ... approval to produce water-based mixtures. The ...
Cached Medicine Technology:Zimmer Holdings Announces Live Audio Webcast and Conference Call of First Quarter 2011 Results 2China Botanic Pharmaceutical Approved to Produce Water-Based Mixtures 2China Botanic Pharmaceutical Approved to Produce Water-Based Mixtures 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: