Navigation Links
Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
Date:2/5/2014

CAMDEN Diseases like Alzheimer's and Huntington's are often associated with aging, but the biological link between the two is less certain. Researchers at Rutgers UniversityCamden are seeking insight into this connection by studying very small RNA molecules in the common fruit fly.

"As the flies in our experiment age, we're able to detect specific patterns of microRNAs which help to regulate genes when they are bound to specific proteins," says Ammar Naqvi, a doctoral student in computational and integrative biology at RutgersCamden.

Naqvi, a Philadelphia resident, explains that microRNAs are connected to various developmental stages and disease states, and their proper modulation is required for the integrity and maintenance of cells.

The research is being done under the supervision of Andrey Grigoriev, a professor of biology at RutgersCamden, and in collaboration with a research team at the University of Pennsylvania. Computational and bioinformatics analysis for the project is performed at RutgersCamden.

In flies, microRNAs are "loaded" onto one of two protein complexes known as Ago1 or Ago2, which then guide it to repress gene expression. The team found that as fruit flies age, more microRNAs accumulate on the Ago2 protein complex, and therefore impact age-associated events in the flies.

"We were able to connect the two processes," Naqvi says. "Studies have shown that there is some change in the microRNA population with age, but no one was sure how they were partitioned with the protein complexes. We observed such partitioning and also an increase in neurodegeneration, which resulted in a shorter lifespan for these flies."

Grigoriev explains, "Neurodegeneration and aging go hand-in-hand, but we are the first to have shown the details of this change in regulation with aging. This tells us that there are different mechanisms of regulation in different stages of development. Is aging a byprod
'/>"/>

Contact: Ed Moorhouse
ejmoor@camden.rutgers.edu
856-225-6759
Rutgers University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Research into fruit fly cells could lead to cancer insights
2. “Fruits for Weight Loss,” a New Article on Healthreviewcenter.com, Gives People Fat-Burning Fruits - Health Review Center
3. Scientists at Cancer Prevention Institute of California Find That a Diet High in Fruits and Vegetables May Significantly Reduce Risk of Breast Cancer
4. Just in Time for Halloween—MyClassifiedAds.net Shares Six Successful Tricks to Finding Fruitful Treats Using Newspaper Ads
5. O Cosmedics Takes Multi-tasking to the Next level With Their Newest Edition 3-in-1 Fruit Peel Mask
6. Whole Foods Markets® Exclusive Introduction of U.S. Made Fruitables® Whole Jerky® Dog Treats
7. From Shofar to Shalom and from Symbolic Fruits to Honey, Rosh Hashanah Ecards Feature Them All at 123Greetings.com
8. African Mango Fruit Pros and Cons Examined for Overweight Adults at eHealthMax.com
9. Diet Doc Medical Weight Loss Plans Now Encourages Natural Weight Loss With Fruits and Vegetables that Help Patients Lose Weight Fast and Live Longer
10. Zion Health's Mineral Beauty Balm Contains Natural SunScreen SPF 30 & Anti-Aging Fruit Peptides- Now Available At Green Acres Health Food Store in Wichita, Kansas.
11. Thomas Hoey of Long Island Banana Corp. Defends Nutritional Quality of Fruit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 Padre Murphy's and Owner Tom Boyle ... Pro Player Health Alliance (PPHA). The PPHA's passion for ... everyone, including NFL greats, treated for obstructive sleep apnea (OSA) ... supporting the cause in the valley. The most recent plans ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue ... means to “Live Fearless.” , The “Faces of ... stories about how they or someone they know has faced ... in the moment. By telling these types of stories through ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 A ... issue of experience and person-centeredness in the long-term care ... towards action across the continuum. The paper, “The Power ... Continuum,” engages perspectives and practices of the patient, resident ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... revenues in the past three years. Today, the business announces ... According to the sales manager of the company, this is ... 2015. This point can be reflected on the discounted wedding ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... Disparities, NASHVILLE, Tenn., Nov. 13 The ... the Meharry Medical,College Center for Women,s Health Research, ... health disparities among women of color. Over the,next ... Center,s work in,addressing diseases that disproportionately impact women ...
... with Public Health, - Seattle & King County and RediClinic, offers Seattle-area residents a, convenient ... themselves and the many lives they touch, ... ... peaked in Seattle between mid ...
... Novartis Vaccines, in partnership with Colorado Influenza and Pneumococcal Alert ... vaccinated against influenza to ... will be conducted be at Town Center at Aurora during ... this special time of ...
... in Quarter, SAN JOSE, Calif., Nov. 13 ... "the Company") today,announced results for the third quarter ended ... in the prior year period,resulted in a net loss ... net,income of $49,000 ($.01 per share) for the same ...
... N.Y. Attorney General on physician evaluations will have,national ... following statement is,attributable to Nancy H. Nielsen, M.D., ... (AMA) welcomes today,s announcement,that New York Attorney General ... agreement he secured last month on,physician ranking programs. ...
... 13 -- The Nurse-Friendly(TM) hospital designation,of Texas Nurses ... in,Texas -- CHRISTUS St. Catherine Hospital, Katy; McKenna ... Center, Round Rock; and St.,David,s South Austin Hospital, ... The Nurse-Friendly designation attests to the presence in ...
Cached Medicine News:Health News:Wal-Mart Foundation Announces $1 Million Grant to the Meharry Medical College Center for Women's Health Research 2Health News:Wal-Mart Foundation Announces $1 Million Grant to the Meharry Medical College Center for Women's Health Research 3Health News:Wal-Mart Foundation Announces $1 Million Grant to the Meharry Medical College Center for Women's Health Research 4Health News:Novartis Vaccines to Host Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 2Health News:Novartis Vaccines to Host Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 3Health News:Novartis Vaccines to Host Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 4Health News:Novartis Vaccines to Host Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 5Health News:Novartis Vaccines to Host Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 6Health News:Colorado Influenza and Pneumococcal Alert Coalition (CIPAC) Partners with Novartis Vaccines for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 2Health News:Colorado Influenza and Pneumococcal Alert Coalition (CIPAC) Partners with Novartis Vaccines for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 3Health News:Colorado Influenza and Pneumococcal Alert Coalition (CIPAC) Partners with Novartis Vaccines for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 4Health News:Human Pheromone Sciences Announces Third Quarter Results 2Health News:Human Pheromone Sciences Announces Third Quarter Results 3Health News:Human Pheromone Sciences Announces Third Quarter Results 4Health News:AMA Commends Aetna for Quality First Commitment 2Health News:Nurse-Friendly Hospital Designation Awarded to Four Texas Hospitals 2
(Date:1/23/2015)... Rose, baseball,s all-time hits leader, is the new spokesperson for ... Pharma has announced. "Pete,s a Hall of Famer ... on board with Myoflex," said Ducere Pharma Chief Executive Officer ... is known across all generations. The passion and intensity that ...
(Date:1/23/2015)... Jan. 23, 2015 Cord Blood America, Inc. ( www.cordblood-america.com ... the "Company")  filed a Preliminary Proxy Statement, Schedule 14A, with ... and provides an update for shareholders detailing why a "YES" ... Dear Shareholders, As we reflect upon ...
(Date:1/23/2015)... and BOSTON , January 23, 2015 ... discovery and development company, is delighted to announce that the ... awarded to Miles Congreve (Vice President of Chemistry), ... Malcolm Weir (Chief Executive Officer and co-founder) for ...
Breaking Medicine Technology:Pete Rose bets on Myoflex to relieve aches and pains 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4
... Aug. 6 Marken, a leading logistics specialist supporting the life science ... . The expansion office will handle the growing demand for management and support ... , ... reach of life science companies in Japan and across the ...
... International Corporation (OTC Bulletin Board: MFLU ) announced today the Company will ... ET . , , , ... , , ... , Michael ...
Cached Medicine Technology:Microfluidics International Corporation to Report Second Quarter 2010 Financial Results on August 10, 2010 2Microfluidics International Corporation to Report Second Quarter 2010 Financial Results on August 10, 2010 3Microfluidics International Corporation to Report Second Quarter 2010 Financial Results on August 10, 2010 4
... 1000 Power Instrument System is a small ... with modular and unitized handpieces.,The head modules ... or pneumatic motor, giving you the flexibility ... the motor. Now you can add instruments ...
... SmartDriver System consists of a ... Electric and Battery Power, with ... that can be used in ... applications., ,Smartdriver Handpiece, available ...
... power line from MicroAire. Our new ... electric instruments, offering the ultimate in ... has always wanted with the security ... Power Master oscillating saw, Available with ...
The 7700 Reciprocating Saw completes the large power system with our simple twist-lock blade hub and selection of saw blades....
Medicine Products: