Navigation Links
Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
Date:2/5/2014

CAMDEN Diseases like Alzheimer's and Huntington's are often associated with aging, but the biological link between the two is less certain. Researchers at Rutgers UniversityCamden are seeking insight into this connection by studying very small RNA molecules in the common fruit fly.

"As the flies in our experiment age, we're able to detect specific patterns of microRNAs which help to regulate genes when they are bound to specific proteins," says Ammar Naqvi, a doctoral student in computational and integrative biology at RutgersCamden.

Naqvi, a Philadelphia resident, explains that microRNAs are connected to various developmental stages and disease states, and their proper modulation is required for the integrity and maintenance of cells.

The research is being done under the supervision of Andrey Grigoriev, a professor of biology at RutgersCamden, and in collaboration with a research team at the University of Pennsylvania. Computational and bioinformatics analysis for the project is performed at RutgersCamden.

In flies, microRNAs are "loaded" onto one of two protein complexes known as Ago1 or Ago2, which then guide it to repress gene expression. The team found that as fruit flies age, more microRNAs accumulate on the Ago2 protein complex, and therefore impact age-associated events in the flies.

"We were able to connect the two processes," Naqvi says. "Studies have shown that there is some change in the microRNA population with age, but no one was sure how they were partitioned with the protein complexes. We observed such partitioning and also an increase in neurodegeneration, which resulted in a shorter lifespan for these flies."

Grigoriev explains, "Neurodegeneration and aging go hand-in-hand, but we are the first to have shown the details of this change in regulation with aging. This tells us that there are different mechanisms of regulation in different stages of development. Is aging a byproduct of development? I cannot tell you. It's possible that this could be relevant for other diseases. That's what we want to find out."

The study was recently published in a leading journal in the field, Genes and Development.

Naqvi, who is originally from Long Island, New York, received his bachelor's degree from Rochester Institute of Technology and his master's degree from George Mason University. He is the recipient of the prestigious Rutgers Presidential Fellowship, annually awarded to select doctoral students throughout the university to help fund research.

Grigoriev, a Medford (NJ) resident, earned his bachelor's and master's degrees in physics from the Moscow Engineering Physics Institute in Russia. He received his doctoral degree in molecular biology from the Institute of Genetics and Selection of Industrial Microorganisms in Russia.


'/>"/>

Contact: Ed Moorhouse
ejmoor@camden.rutgers.edu
856-225-6759
Rutgers University
Source:Eurekalert

Related medicine news :

1. Research into fruit fly cells could lead to cancer insights
2. “Fruits for Weight Loss,” a New Article on Healthreviewcenter.com, Gives People Fat-Burning Fruits - Health Review Center
3. Scientists at Cancer Prevention Institute of California Find That a Diet High in Fruits and Vegetables May Significantly Reduce Risk of Breast Cancer
4. Just in Time for Halloween—MyClassifiedAds.net Shares Six Successful Tricks to Finding Fruitful Treats Using Newspaper Ads
5. O Cosmedics Takes Multi-tasking to the Next level With Their Newest Edition 3-in-1 Fruit Peel Mask
6. Whole Foods Markets® Exclusive Introduction of U.S. Made Fruitables® Whole Jerky® Dog Treats
7. From Shofar to Shalom and from Symbolic Fruits to Honey, Rosh Hashanah Ecards Feature Them All at 123Greetings.com
8. African Mango Fruit Pros and Cons Examined for Overweight Adults at eHealthMax.com
9. Diet Doc Medical Weight Loss Plans Now Encourages Natural Weight Loss With Fruits and Vegetables that Help Patients Lose Weight Fast and Live Longer
10. Zion Health's Mineral Beauty Balm Contains Natural SunScreen SPF 30 & Anti-Aging Fruit Peptides- Now Available At Green Acres Health Food Store in Wichita, Kansas.
11. Thomas Hoey of Long Island Banana Corp. Defends Nutritional Quality of Fruit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from ... at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center ... care topics including advance care planning, healthcare costs and patient and family engagement. ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
Breaking Medicine Technology: