Navigation Links
Fruit fly microRNA research at Rutgers-Camden offers clues to aging process

CAMDEN Diseases like Alzheimer's and Huntington's are often associated with aging, but the biological link between the two is less certain. Researchers at Rutgers UniversityCamden are seeking insight into this connection by studying very small RNA molecules in the common fruit fly.

"As the flies in our experiment age, we're able to detect specific patterns of microRNAs which help to regulate genes when they are bound to specific proteins," says Ammar Naqvi, a doctoral student in computational and integrative biology at RutgersCamden.

Naqvi, a Philadelphia resident, explains that microRNAs are connected to various developmental stages and disease states, and their proper modulation is required for the integrity and maintenance of cells.

The research is being done under the supervision of Andrey Grigoriev, a professor of biology at RutgersCamden, and in collaboration with a research team at the University of Pennsylvania. Computational and bioinformatics analysis for the project is performed at RutgersCamden.

In flies, microRNAs are "loaded" onto one of two protein complexes known as Ago1 or Ago2, which then guide it to repress gene expression. The team found that as fruit flies age, more microRNAs accumulate on the Ago2 protein complex, and therefore impact age-associated events in the flies.

"We were able to connect the two processes," Naqvi says. "Studies have shown that there is some change in the microRNA population with age, but no one was sure how they were partitioned with the protein complexes. We observed such partitioning and also an increase in neurodegeneration, which resulted in a shorter lifespan for these flies."

Grigoriev explains, "Neurodegeneration and aging go hand-in-hand, but we are the first to have shown the details of this change in regulation with aging. This tells us that there are different mechanisms of regulation in different stages of development. Is aging a byproduct of development? I cannot tell you. It's possible that this could be relevant for other diseases. That's what we want to find out."

The study was recently published in a leading journal in the field, Genes and Development.

Naqvi, who is originally from Long Island, New York, received his bachelor's degree from Rochester Institute of Technology and his master's degree from George Mason University. He is the recipient of the prestigious Rutgers Presidential Fellowship, annually awarded to select doctoral students throughout the university to help fund research.

Grigoriev, a Medford (NJ) resident, earned his bachelor's and master's degrees in physics from the Moscow Engineering Physics Institute in Russia. He received his doctoral degree in molecular biology from the Institute of Genetics and Selection of Industrial Microorganisms in Russia.


Contact: Ed Moorhouse
Rutgers University

Related medicine news :

1. Research into fruit fly cells could lead to cancer insights
2. “Fruits for Weight Loss,” a New Article on, Gives People Fat-Burning Fruits - Health Review Center
3. Scientists at Cancer Prevention Institute of California Find That a Diet High in Fruits and Vegetables May Significantly Reduce Risk of Breast Cancer
4. Just in Time for Halloween— Shares Six Successful Tricks to Finding Fruitful Treats Using Newspaper Ads
5. O Cosmedics Takes Multi-tasking to the Next level With Their Newest Edition 3-in-1 Fruit Peel Mask
6. Whole Foods Markets® Exclusive Introduction of U.S. Made Fruitables® Whole Jerky® Dog Treats
7. From Shofar to Shalom and from Symbolic Fruits to Honey, Rosh Hashanah Ecards Feature Them All at
8. African Mango Fruit Pros and Cons Examined for Overweight Adults at
9. Diet Doc Medical Weight Loss Plans Now Encourages Natural Weight Loss With Fruits and Vegetables that Help Patients Lose Weight Fast and Live Longer
10. Zion Health's Mineral Beauty Balm Contains Natural SunScreen SPF 30 & Anti-Aging Fruit Peptides- Now Available At Green Acres Health Food Store in Wichita, Kansas.
11. Thomas Hoey of Long Island Banana Corp. Defends Nutritional Quality of Fruit
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... Lakeview Health, ... country to celebrate their sobriety and show through pictures what a positive difference ... photos this Thanksgiving with the hashtag #FacesOfGratitude on their Facebook, Twitter, and Instagram ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 23rd 2015 Cozy Products, ... heating products business. Cozy Products explains what this means for business moving forward. , ... the Cozy Products business model: to sell personal heaters that reduce energy consumption, are ...
(Date:11/25/2015)... Livonia, MI (PRWEB) , ... November 25, 2015 , ... ... at Presence Resurrection Medical Center (RMC) in Chicago, IL, UV Angel is evaluating the ... the medical and surgical intensive care units (totaling 30 beds) from May 2014 through ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... found that regular bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. ... , She developed the patent-pending RECOVERY BRA for added comfort and support. The ...
(Date:11/25/2015)... ... , ... Since its launch in 2012, the Regenestem brand ... therapies to patients with chronic degenerative medical conditions. Now, the U.S. Patent and ... , Organizations are required to hold a registered trademark in order to make ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 24, 2015  Thanks to a donor with a ... Medical Center,s Sister Diane Grassilli Center for Women,s Health ... San Francisco . ... forward with a gift of $617,320 that allowed the ... with Tomosynthesis and Whole Breast Ultrasound. Tomosynthesis, three-dimensional (3-D) ...
(Date:11/24/2015)... , Nov. 24, 2015  Array BioPharma Inc. ... Chief Executive Officer, Ron Squarer , will ... in New York.  The public is welcome to ... the Array BioPharma website.Event:Piper Jaffray Annual Healthcare ConferencePresenter:  ... December 2, 2015Time:1:30 p.m. Eastern Time Webcast: ...
(Date:11/24/2015)... Nov. 24, 2015 /PRNewswire/ - ESSA Pharma Inc. ("ESSA" ... announced today that the first patient has been enrolled ... a treatment for metastatic castration-resistant prostate cancer ("mCRPC"). ... --> the United States ... Phase 1/2 clinical trial, ESSA intends to demonstrate the ...
Breaking Medicine Technology: