Navigation Links
Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers
Date:2/12/2009

LA JOLLA, CAFruit flies and humans share most of their genes, including 70 percent of all known human disease genes. Taking advantage of this remarkable evolutionary conservation, researchers at the Salk Institute for Biological Studies transformed the fruit fly into a laboratory model for an innovative study of gliomas, the most common malignant brain tumors.

"Gliomas are a devastating disease but we still know very little about the underlying disease process," explains John B. Thomas, Ph.D., a professor in the Molecular Neurobiology Laboratory and senior author of the study, which is published in the current edition of the Public Library of Science Genetics. "We can now use the power of Drosophila genetics to uncover genes that drive these tumors and identify novel therapeutic targets, which will speed up the development of effective drugs."

Better models for research into human gliomas are urgently needed. Last year alone, about 21,000 people in this country were diagnosed with brain and nervous system cancers, Senator Edward M. Kennedy the most famous among them. About 77 percent of malignant brain tumors are gliomas and their prognosis is usually bleak. While they rarely spread to elsewhere in the body, cancerous glial cells quickly infiltrate the brain and grow rapidly, which renders them largely incurable even with current therapies.

Gliomas originate in brain cells known as "glia" and are categorized into subtypes based on how aggressive they appear, with glioblastoma being the most common and most aggressive form of glioma. Their diversity is mirrored by the number of different signaling pathways involved in the generation of these tumors, yet aggressive gliomas all seem to have one thing in common: Most, if not all human glioblastomas carry mutations that activate the EGFR-Ras and PI-3K signaling pathways. Such mutations are also thought to play a key role in developing drug resistance.

"Fruit flies
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
2. Scientists detect presence of marburg virus in african fruit bats
3. Pollen, Fruits, Veggies Help Trigger Oral Allergy Syndrome
4. Get Your Fruits & Veggies: CDC
5. Fruity vegetables and fish reduce asthma and allergies
6. P.A.C.K. Week Declared in Support of Fruits & Veggies-More Matters Month
7. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
8. Fruits, Veggies Wont Lower Colon Cancer Risk
9. Fruit and vegetables health
10. Abbott Launches Fruitified(TM) ZonePerfect(R) All-Natural Nutrition Bars
11. Fish, Fruits, Veggies May Cut Dementia Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers
(Date:9/23/2014)... Hills, CA (PRWEB) September 23, 2014 ... of Diabetes and Digestive and Kidney Diseases ... leading to more cases of adults and children developing ... patients from 2005 - 2011 across several U.S. cities, ... Researchers discovered that patients usually sought treatment for kidney ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 Dr. ... on the restoration and replacement of teeth, recently ... of Restorative Dentistry and Prosthodontics (CARDP) annual Scientific ... prosthodontist at the Anacapa Dental Art Institute, on ... Esthetic Implant Supported Maxillary Prostheses” at 2:30 p.m. ...
(Date:9/23/2014)... 2014 Eight-week program, “Healing Female Pain” reaches ... other chronic pelvic or sexual pain, teaching intuitive Mind Body ... the Gallup poll, 1 in 7 women between the ages ... Many of those women suffer in silence, finding it difficult ... type of pain varies from woman to woman and can ...
(Date:9/23/2014)... New York, NY (PRWEB) September 23, 2014 ... managed IT solutions firm based in New York City, ... 7 to approximately 3,000 desktop clients located in the ... The upgrade will help modernize the bank’s corporate and ... their NY Metro branch locations, and their NY Metro ...
(Date:9/23/2014)... Irvine, CA (PRWEB) September 23, 2014 ... encourages personal growth and exploration through the presentation ... available for download in the Apple® App Store. ... to contribute compelling and informative content to the ... to gain new followers and expand audience reach, ...
Breaking Medicine News(10 mins):Health News:New Study Finds Link Between Higher Temperatures and Kidney Stones in the United States 2Health News:New Study Finds Link Between Higher Temperatures and Kidney Stones in the United States 3Health News:Woodland Hills Dental Implant Center Owner, One of Ventura’s Best Cosmetic Dentists, Returns from Prestigious Speaking Engagement to Canada’s Elite Dental Professionals 2Health News:Woodland Hills Dental Implant Center Owner, One of Ventura’s Best Cosmetic Dentists, Returns from Prestigious Speaking Engagement to Canada’s Elite Dental Professionals 3Health News:Woodland Hills Dental Implant Center Owner, One of Ventura’s Best Cosmetic Dentists, Returns from Prestigious Speaking Engagement to Canada’s Elite Dental Professionals 4Health News:Mind Body Expert Launches Pelvic Pain Relief Program 2Health News:Calling All Experts: New Mobile Learning App Accepting Content Contributors 2
... Mylan Inc. (Nasdaq: MYL ) today ... Genpharm ULC received final approvals from the U.S. ... New Drug Applications (ANDAs) for Lamotrigine Tablets. Genpharm ... for a separate Lamotrigine product, Lamotrigine Tablets Chewable ...
... Challenges Venture Industry to Step Up Investments in Healthcare ... States is on the verge of building a "new ... healthcare venture capital firm Psilos Group. But the same ... the Obama administration, the economics of healthcare will not ...
... Dr. Michael Forster of the UNT Health ... University of Southern California,s School of ... be a key to living longer. Their study ... recently published in several scientific journals and articles.The ...
... Resources, Gold Standard for Rheumatoid Arthritis in 2012, ... Mass., Jan. 28 Decision Resources, one of ... pharmaceutical and healthcare issues, finds that surveyed rheumatologists ... signs and symptoms of rheumatoid arthritis at one ...
... -Expects to File Pennsaid FDA Resubmission Within 60 ... Inc. (TSX: NRI), a Canadian drug development company ... products delivered to and through the skin using ... announced that it has successfully completed all of ...
... Jan. 28 BD (Becton, Dickinson and Company) (NYSE: ... for the first fiscal quarter ended December 31, 2008, representing ... This quarter,s growth rate reflects the unfavorable impact from ... nearly 3 percentage points. "BD is off to a ...
Cached Medicine News:Health News:Mylan Receives Final FDA Approvals for Generic Versions of Lamictal(R) Tablets and Lamictal(R) CD 2Health News:Obama Reforms Could Spark 'New Healthcare Economy' If Investors Increase Funding, Says Leading Healthcare Venture Firm 2Health News:Obama Reforms Could Spark 'New Healthcare Economy' If Investors Increase Funding, Says Leading Healthcare Venture Firm 3Health News:Obama Reforms Could Spark 'New Healthcare Economy' If Investors Increase Funding, Says Leading Healthcare Venture Firm 4Health News:UNT Health Science Center Researchers Discover Eating Less May Not Increase Life Expectancy 2Health News:UNT Health Science Center Researchers Discover Eating Less May Not Increase Life Expectancy 3Health News:Current and Emerging Therapies Have No Advantage Over Enbrel in Reducing the Signs and Symptoms of Rheumatoid Arthritis 2Health News:Current and Emerging Therapies Have No Advantage Over Enbrel in Reducing the Signs and Symptoms of Rheumatoid Arthritis 3Health News:Nuvo Research Announces Successful Completion Of All Pennsaid(R) Studies 2Health News:Nuvo Research Announces Successful Completion Of All Pennsaid(R) Studies 3Health News:Nuvo Research Announces Successful Completion Of All Pennsaid(R) Studies 4Health News:BD Announces Results for First Fiscal Quarter 2Health News:BD Announces Results for First Fiscal Quarter 3Health News:BD Announces Results for First Fiscal Quarter 4Health News:BD Announces Results for First Fiscal Quarter 5Health News:BD Announces Results for First Fiscal Quarter 6Health News:BD Announces Results for First Fiscal Quarter 7Health News:BD Announces Results for First Fiscal Quarter 8Health News:BD Announces Results for First Fiscal Quarter 9Health News:BD Announces Results for First Fiscal Quarter 10
(Date:9/23/2014)... 23, 2014   BioLife Solutions , Inc. (NASDAQ: ... marketer of proprietary clinical grade hypothermic storage ... thermal shipping products for cells and tissues  ("BioLife" ... its Scientific Advisory Board.  The new members are ... PhD. Dr. Acker is a Senior Development ...
(Date:9/22/2014)... Spain , September 23, 2014 ... to meet health authorities, increasing rigor for trial master ... life sciences industry,s largest TMF survey to date reveals ... that plan to provide auditors with remote access to ... of TMF owners surveyed in the Veeva ...
(Date:9/22/2014)... The western European automated endoscope reprocessor ... a replacement market with fewer new installations due ... partnerships are redefining competitive landscape in western ... details about revenue forecasts, unit shipments, market share ... country. The changing landscape makes it important to ...
Breaking Medicine Technology:BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 2BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 3BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 4BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 5BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 6BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 7Remote eTMF Access to Double in 2015, Reveals Industry-wide Survey 2Remote eTMF Access to Double in 2015, Reveals Industry-wide Survey 3Remote eTMF Access to Double in 2015, Reveals Industry-wide Survey 4Automated Endoscope Reprocessor Market Trends in Western Europe 2Automated Endoscope Reprocessor Market Trends in Western Europe 3
... 6, 2011 The American Animal Hospital Association ... ) are collaborating on a new series for online ... real-life examples, the "Solve It! Series" combines engaging content ... element of mystery. Designed by a panel of experts, ...
... 6, 2011 ContinuumRx and Mississippi Baptist Health Systems ... new home infusion pharmacy that will serve ... model designed to improve patient outcomes with a more ... partnership will not only improve our core operations and ...
Cached Medicine Technology:American Animal Hospital Association and Heska Corporation Announce New Online Continuing Education Series 2ContinuumRx Forms Healthcare Joint Venture with Mississippi Baptist Health Systems 2
Half pin skeletal traction pins with cove point....
Instera pins are sterile packaged and are available in 0.89, 1.1, 1.5, and 2.0mm diameters....
Knowles Pins are available in 9" (228mm) overall length with 9/64" (3.5mm) shaft diameter and 1/4" (6.4mm) square bead....
Kirschner Wires are available in four point styles ranging from .028 to .062 in. Smooth tip wire available in 4, 6 and 9 in. lengths. Threaded tip available. Material: DePuy certified stainless steel...
Medicine Products: