Navigation Links
Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers
Date:2/12/2009

LA JOLLA, CAFruit flies and humans share most of their genes, including 70 percent of all known human disease genes. Taking advantage of this remarkable evolutionary conservation, researchers at the Salk Institute for Biological Studies transformed the fruit fly into a laboratory model for an innovative study of gliomas, the most common malignant brain tumors.

"Gliomas are a devastating disease but we still know very little about the underlying disease process," explains John B. Thomas, Ph.D., a professor in the Molecular Neurobiology Laboratory and senior author of the study, which is published in the current edition of the Public Library of Science Genetics. "We can now use the power of Drosophila genetics to uncover genes that drive these tumors and identify novel therapeutic targets, which will speed up the development of effective drugs."

Better models for research into human gliomas are urgently needed. Last year alone, about 21,000 people in this country were diagnosed with brain and nervous system cancers, Senator Edward M. Kennedy the most famous among them. About 77 percent of malignant brain tumors are gliomas and their prognosis is usually bleak. While they rarely spread to elsewhere in the body, cancerous glial cells quickly infiltrate the brain and grow rapidly, which renders them largely incurable even with current therapies.

Gliomas originate in brain cells known as "glia" and are categorized into subtypes based on how aggressive they appear, with glioblastoma being the most common and most aggressive form of glioma. Their diversity is mirrored by the number of different signaling pathways involved in the generation of these tumors, yet aggressive gliomas all seem to have one thing in common: Most, if not all human glioblastomas carry mutations that activate the EGFR-Ras and PI-3K signaling pathways. Such mutations are also thought to play a key role in developing drug resistance.

"Fruit flies
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
2. Scientists detect presence of marburg virus in african fruit bats
3. Pollen, Fruits, Veggies Help Trigger Oral Allergy Syndrome
4. Get Your Fruits & Veggies: CDC
5. Fruity vegetables and fish reduce asthma and allergies
6. P.A.C.K. Week Declared in Support of Fruits & Veggies-More Matters Month
7. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
8. Fruits, Veggies Wont Lower Colon Cancer Risk
9. Fruit and vegetables health
10. Abbott Launches Fruitified(TM) ZonePerfect(R) All-Natural Nutrition Bars
11. Fish, Fruits, Veggies May Cut Dementia Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers
(Date:4/18/2014)... device is being prepped to enter the battle ... of certain diseases in remote areas, thanks in ... investigations aboard the International Space Station on the ... concept of capillary flow to diagnose infectious diseases ... Ph.D., a researcher at Northwestern University in Evanston, ...
(Date:4/18/2014)... Hopkins University School of Medicine researchers have been awarded ... diabetes, Novo Nordisk announced this month. Of the 110 ... Obesity Biologics Science Forum Program, only four projects were ... researchers. They are Jonathan Powell, M.D., Ph.D.; G. William ... Jonathan Powell, a professor of oncology, will use his ...
(Date:4/18/2014)... a brain-related discovery that could revolutionize doctors, perception ... opens up the possibility that environmental and/or genetic ... activity that the researchers have identified as helping ... Neuroscience has just published a paper about ... of psychology and his doctoral student John Gaspar, ...
(Date:4/18/2014)... to potential new treatments for breaking the cycle of ... or scarring, is a hallmark of the disease, and ... to serious organ damage and, in some cases, death. ... findings made by Swati Bhattacharyya, PhD, research assistant professor ... protein plays in promoting fibrosis. , "Our results ...
(Date:4/17/2014)... first genetic variant specifically associated with the risk ... 10-15 per cent of all breast cancer cases. ... cancer sub-type, called invasive lobular carcinoma, gives researchers ... particular kind of breast cancer, which can be ... (Thursday) in the journal PloS Genetics , ...
Breaking Medicine News(10 mins):Health News:Space-tested fluid flow concept advances infectious disease diagnoses 2Health News:Space-tested fluid flow concept advances infectious disease diagnoses 3Health News:Scientists discover brain's anti-distraction system 2Health News:New clues on tissue scarring in scleroderma 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3
... long-term contract to provide medical billing services for the Seton Family ... delivering quality service and affordable medical billing solutions are cited in ... , ... Austin, Texas (PRWEB) May 10, 2009 -- ...
... Integrated Solution for Mail Server Data Protection and Quick Recovery ... ... CA and Melville, NY (PRWEB) May 11, 2009 -- MessageSolution, ... solutions for electronic discovery, litigation support, compliance and storage management, ...
... wipes are alcohol based. Over-use of hand sanitizers cause more health ... open a direct pathway to the human bloodstream. Q-Based Healthcare ... ... Erath, Louisiana (PRWEB) May 11, 2009 -- A Louisiana company, ...
... Released During National Women,s Health Week Points to Importance ... released today on gender-based differences in mental health shows ... suffer from major depression. The report addresses many ... trauma and violence can have on long term mental ...
... 11 , - New Hayfever Relief ... Available on the Internet , - With ... 200 years ago, however, it,s believed that,it now affects as many ... do suffer,with hayfever, it,s either complete misery with symptoms such as ...
... areas are more likely to develop late-stage cancer than those ... conclusion of a new study published in the June 15, ... the American Cancer Society. The study,s results indicate a need ... Diagnosing cancer at an early stage can improve outcomes. ...
Cached Medicine News:Health News:AMPM to Provide Medical Billing Services for Seton Community Health Centers in Austin 2Health News:MessageSolution and FalconStor Deliver Turnkey Solution for Enterprise Archiving, DR, and High-Availability 2Health News:MessageSolution and FalconStor Deliver Turnkey Solution for Enterprise Archiving, DR, and High-Availability 3Health News:MessageSolution and FalconStor Deliver Turnkey Solution for Enterprise Archiving, DR, and High-Availability 4Health News:MessageSolution and FalconStor Deliver Turnkey Solution for Enterprise Archiving, DR, and High-Availability 5Health News:Q-Based Healthcare Warns: Hand Sanitizers Increase Risk of Swine Flu Exposure 2Health News:Q-Based Healthcare Warns: Hand Sanitizers Increase Risk of Swine Flu Exposure 3Health News:Women at Greater Risk for Depression and Anxiety 2Health News:Women at Greater Risk for Depression and Anxiety 3Health News:'Qu-Chi' Acupressure Band Gives Hayfever Misery the Elbow 2Health News:'Qu-Chi' Acupressure Band Gives Hayfever Misery the Elbow 3Health News:City-dwellers have higher risk of late-stage cancer than rural residents 2
(Date:1/15/2014)... Jan. 15, 2014  Manufacturers, suppliers and distributors of ... to protect their most important business assets, intellectual ... ) Because of the highly-competitive nature ... one of the most litigious industry sectors of ...
(Date:1/15/2014)... Medical is very pleased to announce the appointment of Mr. ... Officer.  Mark was promoted from his current role of Chief ... facilities in Massachusetts , Mississippi ... in 2012 with 20+ years of broad-based operations, sales, engineering ...
(Date:1/15/2014)... , Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... its Symphony® CGM System as a non-invasive, wireless continuous ... Doman , Executive Chairman and Interim CEO of Echo ... Tenth Annual Equity Conference. Mr. Doman ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
Eliminate preanalytical errors with automated QC module....
Non-invasive and continuous tcpCO2 and tcpO2 patient monitoring....
... Submit your analyzer data via the ... a worldwide peer group. , ... you to perform statistical analysis of ... often as you like. Peer-group data ...
Automated QC module...
Medicine Products: