Navigation Links
Fruit flies reveal mechanism behind ALS-like disease
Date:6/13/2012

Studying how nerve cells send and receive messages, Johns Hopkins scientists have discovered new ways that genetic mutations can disrupt functions in neurons and lead to neurodegenerative disease, including amyotrophic lateral sclerosis (ALS).

In a report published April 26 in Neuron, the research team says it has discovered that a mutation responsible for a rare, hereditary motor neuron disease called hereditary motor neuropathy 7B (HMN7B) disrupts the link between molecular motors and the nerve cell tip where they reside. This mutation results in the production of a faulty protein that prevents material from being transported from the cell's edge, which is located at the muscle and extends back toward its "body" in the central nervous system. In pinpointing how and where this cargo transport is disrupted, the scientists are now closer to understanding mechanisms underlying this condition and ALS.

"An important question we need to answer is how defects in proteins that normally perform important cellular functions for neurons lead to disease," says Alex Kolodkin, Ph.D., a Howard Hughes Medical Institute Investigator and professor of neuroscience at the Johns Hopkins University School of Medicine. "A major issue in understanding neurodegenerative diseases is determining how certain proteins that are expressed in all types of neurons, or even in all cells in the body, can lead to devastating effects in one, or a few, subsets of neurons." Kolodkin notes that many neurodegenerative diseases involve proteins that serve general functions required in nearly every type of cell in the body, including the transport of material between different parts of a cell, yet certain alterations in these proteins can result in specific neurological disorders.

One particular protein, p150glued, is known to play a role in at least two of these disorders, HMN7B, which is similar to ALS, and Perry syndrome, which leads to symptoms similar to Parkins
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Exercise and a healthy diet of fruits and vegetables extends life expectancy in women in their 70s
2. For Healthier Eating, Keep Fruits, Veggies Within Reach
3. Here Are Fruits, Veggies That Offer Best Bang for Your Buck
4. Red wine, fruit compound could help block fat cell formation
5. Novel biomarkers reveal evidence of radiation exposure
6. A closer look at PARP-1 reveals potential new drug targets
7. Biomarkers can reveal IBS
8. Study reveals major funding shortfall and high death rates for emergency laparotomy
9. New Method to Reveal Alzheimers Marker Shows Promise
10. Study reveals how cancer drug causes diabetic-like state
11. Probing the mechanism of ADAM28-mediated cancer metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... 03, 2015 , ... Representatives with Health Food Grocers today announced ... ‘Ask a Nutritionist’ feature on our website is a free service to our community ... and spokeswoman for Health Food Grocers. , Health Food Grocers’ website offers a variety ...
(Date:8/3/2015)... ... August 03, 2015 , ... Code , an industry ... cable , a Bluetooth Code Reader accessory that enables a wireless connection between the ... T500 helps enable a variety of barcode reading applications with iPads, Galaxy Tabs, and ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... the Atlanta Journal Constitution, the new Lifetime reality series, “Atlanta Plastic” is getting ... and who receives plastic surgery, with its predominantly African-American cast of doctors and ...
(Date:8/3/2015)... ... August 03, 2015 , ... They know every second counts. ... Vincent Medical Center offers some of the best care in the nation. For the ... achieved the fastest average blood clot removal time in the country. During the months ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... ruled in favor of the firm’s client Rebecca Hamsher, deciding that in accordance ... must reimburse benefits for Hamsher’s residential treatment for bulimia, depression and other mental ...
Breaking Medicine News(10 mins):Health News:Health Food Grocers Launches "Ask a Nutritionist" Service 2Health News:Health Food Grocers Launches "Ask a Nutritionist" Service 3Health News:Code Launches the T500, an Innovative Code Reader Accessory 2Health News:Code Launches the T500, an Innovative Code Reader Accessory 3Health News:Article on Lifetime’s New “Atlanta Plastic” Reality Series Underlines the Diversity of Today’s Plastic Surgery Patients, Says Plastic Surgeon Dr. J 2Health News:Article on Lifetime’s New “Atlanta Plastic” Reality Series Underlines the Diversity of Today’s Plastic Surgery Patients, Says Plastic Surgeon Dr. J 3Health News:Providence St. Vincent Stroke Care Recognized Among Best in the Country 2Health News:Providence St. Vincent Stroke Care Recognized Among Best in the Country 3Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 2Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 3
... and Podcast VOORHEES, N.J., Feb. 26 The ... is changing and has been marked by increasing ... the epidemic strain continues to be reported in ... States, and worldwide.To address the need for current ...
... Corporation (NYSE: CVS ) today announced ... Officer and Chief Administrative Officer, will be making ... Institutional Investors Conference on March 10, 2009. Mr. ... a.m. EDT. (Logo: http://www.newscom.com/cgi-bin/prnh/20090226/NE75914LOGO )An ...
... for Tired Baby BoomersMINNEAPOLIS, Feb. 26 ... findings indicating that Bioenergy Ribose(TM) lessens fatigue ... at the Scripps Integrative Conference(1). Bioenergy Ribose ... functional ingredient for foods and beverages as ...
... do not save more in treatment costs under ... are healthier, according to a recent study. , ... patients, payers and employers," said Dennis Scanlon, professor ... lead author of the study. "Assessing the financial ...
... appearing in the March 2009 issue of the ... lead to improvements in the efficacy of the current ... a new role for type I interferon, in which ... an immune response against the bacterium known to cause ...
... day be used as an ingredient in sunscreen, researchers say ... suggested that caffeine might offer some protection from skin cancer, ... what we believe to be the mechanism by which caffeine ... Paul Nghiem, an associate professor of dermatology at the University ...
Cached Medicine News:Health News:Interview with GI Experts: Discussions in Clostridium difficile 2Health News:CVS Caremark Corporation to Present at the Raymond James Institutional Investors Conference on March 10th 2Health News:Bioenergy Ribose Found to Improve Vitality, Aerobic Fitness and Mental Outlook 2Health News:Bioenergy Ribose Found to Improve Vitality, Aerobic Fitness and Mental Outlook 3Health News:Team-based diabetes care fetches more value for dollar 2Health News:New discovery gives tuberculosis vaccine a shot in the arm 2Health News:Caffeine May Offer Some Skin Cancer Protection 2Health News:Caffeine May Offer Some Skin Cancer Protection 3
(Date:8/3/2015)... , Aug. 3, 2015  BC Technical, the nation,s ... Ohio Valley Medical Systems, one of the largest MRI ... addition of Ohio Valley Medical Systems allows BC Technical ... Hitachi MRI.   "We couldn,t be more ... President and CEO of BC Technical. "The Ohio Valley ...
(Date:8/3/2015)... HOUSTON and MINNEAPOLIS ... BSX ) has become a significant shareholder ... marketing representative for Preventice Solutions for cardiology-related diagnostic ... marks an important strategic milestone for Preventice Solutions," ... Global Strategy Officer, co CEO, Preventice Solutions.  "We ...
(Date:8/3/2015)... Ill. , Aug. 3, 2015 Your ... problem, and you,re looking for the best possible outcome. ... the best outcome too, and now there,s a ... Following steps recommended by the American Orthopaedic Foot ... surgery can help you avoid complications and heal as ...
Breaking Medicine Technology:BC Technical Acquires Ohio Valley Medical Systems 2Boston Scientific Announces Equity Investment And Sales Cooperation Agreement With Preventice Solutions 2Patient Guide: How to Prepare for Surgery 2
... ROCKVILLE, Md., Oct. 15 Novavax, Inc. (Nasdaq: ... Chief Executive Officer, and members of senior management will provide ... results via a webcast and conference call on Friday, November ... access the live audio webcast of the conference call, or ...
... CareFusion (NYSE: CFN ), a leading, global ... disclosed recall of approximately 17,000 Alaris® PC units model 8015 ... FDA has classified this action as a Class I recall. ... is a reasonable probability that the use of or exposure ...
Cached Medicine Technology:CareFusion Recall of Alaris PC Units Model 8015 Classified as Class I Recall 2CareFusion Recall of Alaris PC Units Model 8015 Classified as Class I Recall 3
Open 14 mm blades with 6 mm lifting wings. Dull finish....
Solid 14 mm blades. Dull finish....
Angled upward 45 degrees for temporal approach. Open 14 mm blades....
Pediatric model. Blades: 10 mm. Solid blades with locking mechanism. Dull finish....
Medicine Products: