Navigation Links
Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
Date:7/30/2012

By studying fruit flies, scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have successfully devised a fast and cost-saving way to uncover genetic changes that have a higher potential to cause cancer. With this new approach, researchers will now be able to rapidly distinguish the range of genetic changes that are causally linked to cancer (i.e. "driver" mutations) versus those with limited impact on cancer progression. This research paves the way for doctors to design more targeted treatment against the different cancer types, based on the specific cancer-linked mutations present in the patient. This study published in the prestigious journal Genes & Development could help advance the development of personalised medicine in cancer care and treatment.

The era of genomic sequencing has generated an unparalleled wealth of information on the complexity of genetic changes that occur as cancer develops and progresses. "Many genetic changes arise in cancer cells and changes continue to accumulate during the progression of disease to metastatic cancer [1]. The current challenge is to understand which of the many genetic changes are important drivers of disease progression" said Dr. Stephen Cohen, Principal Investigator at IMCB and team leader of this paper.

Though very different in many ways, fruit flies and humans share similarities in a remarkable two-thirds of their genomes. That is to say, many of the genes found in humans are also present in the flies. Similarly, various signalling pathways involved in tumour formation are also well conserved from fruit flies to humans. In fact, previous studies have shown that about 75 percent of known human disease genes have a recognisable match in the genome of fruit flies [2].

Leveraging on their genetic similarities, Dr Hctor Herranz, a post-doctorate from the Dr Cohen's team developed an innovative strategy to genetically screen the whole fly genome for "cooperat
'/>"/>

Contact: Dr. Sarah Chang
chang_kai_chen@a-star.edu.sg
65-682-66442
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Fruit flies reveal mechanism behind ALS-like disease
2. Exercise and a healthy diet of fruits and vegetables extends life expectancy in women in their 70s
3. For Healthier Eating, Keep Fruits, Veggies Within Reach
4. Here Are Fruits, Veggies That Offer Best Bang for Your Buck
5. Red wine, fruit compound could help block fat cell formation
6. John Theurer Cancer Center researchers shed light on new multiple myeloma therapy
7. Some harmful effects of light at night can be reversed
8. Even Slight Mental Decline Can Harm Health, Studies Suggest
9. Spaceflight may extend the lifespan of microscopic worm
10. Light Fireworks Not Cigarettes this Fourth of July with South Beach Smoke
11. Eczema Non-Profit Seeks To Shine New Light On Overlooked Condition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
(Date:4/24/2015)... 24, 2015 The Fastest Fat Loss Week ... great success of the Xtreme Fat Loss Diet, has been ... fat loss blueprint that claims to help one lose belly ... HealthyandFitZone.com's Stan Stevenson, prompting an investigative review. , "Our ... creators spent years researching and experimenting with these methods on ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Lowcostcarinsuranceprice.com has ... low cost auto insurance for senior citizens . ... drivers, but this does not mean that they cannot ... even senior drivers can find the right coverage for ... insurance brokerage website like http://lowcostcarinsuranceprice.com/ provides free ...
(Date:4/24/2015)... 2015 “Kind,” “selfless,” “the voice of ... ways Denise Weiner described pediatric oncology nurse Laura Vasquez ... daughter, Alexa, during her five-year battle with a malignant ... marrow transplant and numerous experimental treatments, Vasquez continued caring ... when she was not in the hospital and even ...
(Date:4/24/2015)... “ Opera ” was featured on NewsWatch as ... and coolest technology products available to consumers. Andrew Tropeano, a ... and shared with viewers how this is the fastest way ... internet would not be in existence. But each web browser ... is no different. Celebrating their 20th anniversary this year, Opera ...
(Date:4/24/2015)... Pastor and Overseer at The House of Yahweh, has written ... worldwide, and how they would not be necessary if the ... nations have been trained to build up armed defense forces ... and distrust. , “The nations believe they must use ... rules and laws, and the rape of their sons, daughters, ...
Breaking Medicine News(10 mins):Health News:Fastest Fat Loss Week Ever Review Revealed on Healthy & Fit Zone 2Health News:Low Cost Auto Insurance Quotes for Senior Citizens 2Health News:CURE™ Magazine Names Pediatric Nurse Laura Vasquez from Children’s Hospital Los Angeles As Extraordinary Healer™ of 2015 2Health News:CURE™ Magazine Names Pediatric Nurse Laura Vasquez from Children’s Hospital Los Angeles As Extraordinary Healer™ of 2015 3Health News:CURE™ Magazine Names Pediatric Nurse Laura Vasquez from Children’s Hospital Los Angeles As Extraordinary Healer™ of 2015 4Health News:A Web Browser That Connects over 350 Million People was Featured on NewsWatch Television 2Health News:Armed Forces Would Not Be Necessary if Biblical Laws Were Followed, Says Yisrayl Hawkins in New Article 2
... and education complex in Islamabad to cater to the health ... the twin city of Rawalpindi . ,The complex ... a Health and Education City in the capital, and includes ... dentistry. ,Harvard Medical International (HMI) is a ...
... and a standardized rehabilitation protocol are successful in returning ... today at the 2007 Annual Meeting of the American ... Center. ,Dr. Brunt and colleagues studied the ... to evaluate the experience of athletes undergoing tension-free mesh ...
... of the American Orthopaedic Society for Sports Medicine at ... in the arm bone and soft tissue of the ... help protect them against injury. ,Young baseball ... as they mature, says principal investigator Scott D. Mair, ...
... of sex, a move that is proving highly controversial among ... workers more vulnerable . ,Men who buy sex ... fine or face both, under proposed legislation currently under consultation ... the buying of sex, but not the sale. Procuring, or ...
... what Victoria Beckham is really wishing for, is a baby girl ... that she and hubby David Beckham will try to add to ... hoping theyll be bringing back a bundle of pink from the ... little girl, is because after all those boys in the house, ...
... Institute for Learning and Memory have uncovered a molecular ... traumatic events . ,The work could lead ... adults who suffer each year from persistent, debilitating fears ... Iraq and Afghanistan. ,A study conducted by the ...
Cached Medicine News:Health News:Surgical Repair of Athletic Hernia Speeds Return to Play 2Health News:Surgical Repair of Athletic Hernia Speeds Return to Play 3Health News:Shoulder Protection by Throwing Motion in Baseball Players 2Health News:Prostitutes Fume as Norway Bids to Criminalise Sex Purchases 2Health News:Prostitutes Fume as Norway Bids to Criminalise Sex Purchases 3Health News:First Drug for Post-traumatic Stress Disorder 2
(Date:4/23/2015)... Ga. , April 23, 2015 WellStar ... care available to its patients with the most advanced ... in Georgia to offer TomoTherapy ... United States to offer both TomoTherapy and ... TomoTherapy System rotates 360 degrees around the patient, which ...
(Date:4/23/2015)... , April 23, 2015  Hill-Rom Holdings, Inc., (NYSE: ... management presentation at the Deutsche Bank 40 th ... 9:20 a.m. EDT. You are invited to ... at http://ir.hill-rom.com/events.cfm or access it directly at ... will be available one hour after conclusion of the ...
(Date:4/23/2015)... 2015  To commemorate the upcoming 25 th anniversary of ... long-anticipated ADA Legacy Tour will make a stop at ... at the New Jersey Convention & Expo Center in ... will be Friday and Saturday 11 am to 5 pm, and ... Tour is a traveling exhibit designed to raise public awareness and ...
Breaking Medicine Technology:WellStar's New, Highly Targeted Therapy Shortens Cancer Treatment Time 2ADA 25th Anniversary Legacy Tour Stops at Abilities Expo New York Metro, May 1-3 2ADA 25th Anniversary Legacy Tour Stops at Abilities Expo New York Metro, May 1-3 3
... , WILMINGTON, Del., Dec. 8 ... enrolled in the company,s Medicare Part D prescription savings program ... program. , (Logo: http://www.newscom.com/cgi-bin/prnh/20091027/PH99766LOGO ) , ... physician,s offices under the changes to the AZ&Me(TM) Prescription Savings ...
... , WALTHAM, ... leading research and advisory firms for pharmaceutical and healthcare issues, ... levofloxacin, moxifloxacin and piperacillin/tazobactam -- will be the primary factors ... the community-acquired pneumonia drug market though 2018. , The new ...
Cached Medicine Technology:AstraZeneca Medicare Part D Patient Assistance Program No Longer Requires Co-Pays 2Patent Expiries of Blockbuster Antibiotics Will Fuel a Decline of More Than 15 Percent in the Community-Acquired Pneumonia Drug Market 2
... New Sorvall Discovery 90SE ... need to discover more. ... come with top-of-the-line performance, ... ease of use, all ...
... centrifuge continues to raise the standard for ... 1,048,000 x g performance and our new ... sample sizes from 0.2 ml to 8.3 ... direct drive, very quiet operation, rotor imbalance ...
... versatility, and environmental safety are ... LE-80 K Ultracentrifuge from Beckman ... Optima centrifugation technology, the LE-80 ... effectively provide advanced capability for ...
... Capable of generating 694,000 ... to 90,000 rpm, Beckman Coulter's ... to perform more separations in ... model operates with a broad ...
Medicine Products: