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Frost & Sullivan Selects Bone Solutions for Technology Leadership of the Year Award
Date:6/22/2009

orts medicine injury repair, as well as several key segments of orthopedics and orthobiologics.

Over the last decade, end users have increasingly accepted the clinical application of these bone fillers/cements as bone substitutes in trauma and orthopedic surgery. Scientists have intensively investigated Ca-phosphate compounds including tricalcium phosphates, Ca sulfates and hydroxyapatite.

Researchers are also exploring the potential of injectable Ca-based pastes as delivery vehicles for proteins such as bone morphogenetic protein (BMP) 2 for fractures. However, their slow absorption rate and non-adhesive qualities limit their utility to being carriers for other materials that may promote bone formation and providing a scaffold for bony ingrowth. Biomechanically, cements do not offer adhesive properties and are weak under tension.

"Increasing evidence shows that Mg-based implants promote bone formation during healing (osteoconduction), and may ultimately show in future FDA filings the ability of growing new bone (osteogenisis) and Mg-based alloys are being studied as orthopedic biomaterials," notes Shetty. "Looking to the future, BSI is also investigating alternative new products based on its magnesium-oriented technology, as Mg-based bone void filler may be less prone to other complications associated with Ca-based biomaterials such as the activation of clotting."

Owing to the application breadth, BSI has large, fragmented addressable markets, totaling $3 billion globally. The company is exploring licensing or joint venturing for various orthopedic applications, including trauma for synthetic bone grafts, sports medicine, extremities, maxillofacial/cranial, and dental.

Following its FDA 510 (k) clearance, BSI plans to complete a series of four additional 510(k) approvals as bone void filler for cranial applications, for maxillofacial applications, and for non-load bearing spine app
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