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Frost & Sullivan Recognizes Neotropix's Approach to the Treatment of Small Cell Lung Cancer and Neuroendocrine Cancers
Date:1/13/2009

Innovative Therapy Ensures Greater Patient Compliance, Improves Quality of Life

MOUNTAIN VIEW, Calif., Jan. 13 /PRNewswire/ -- Based on its recent analysis of the biopharmaceuticals market, Frost & Sullivan recognizes Neotropix, Inc. with the 2009 U.S. Frost & Sullivan Award for Product Innovation of the Year. This award acknowledges the company's introduction of the innovative virotherapy NTX-010 (Seneca Valley Virus), an oncolytic picorna virus for treating small cell lung cancer (SCLC) and other neuroendocrine cancers. This state-of-the-art product aids cancer treatment by using a naturally occurring, replication-competent, single-stranded ribonucleic acid (RNA) virus.

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NTX-010's benefits include a convenient once-only dosing and an attractive side effect profile. It has the potential to address unmet needs in the treatment of adults with small cell cancer and carcinoid cancer. It can also potentially treat children with neuroblastoma, Wilms' tumor, Retinoblastoma, Ewing's sarcoma, Rhabdoid tumor, alveolar rhabdomyosarcoma, and glioblastoma.

This virus, through a receptor-mediated process, selectively targets neuroendocrine tumor cells that express at least one of the following three biomarkers: synaptophysin, CD56, or chromogranin A. "NTX-010 is extremely selective and potent for killing tumor cells. In addition, no normal human cell has been shown to be infectable. Furthermore, NTX-010 is non-pathogenic in multiple animals including mice, swine, primates, and humans," says Frost & Sullivan Research Analyst Katheryn Symank.

People with SCLC have very low survival rates and current treatments are limited to surgery, chemotherapy, and radiation. Patients also suffer from the significant toxic effects fr
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