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Frost & Sullivan Lauds Toscana Biomarkers' Outstanding Contributions to the R&D of Novel Biomarkers for the Diagnosis of Autoimmune Diseases
Date:1/13/2009

LONDON, Jan. 13 /PRNewswire/ -- Based on its recent analysis of the autoimmune disease diagnostics markets, Frost & Sullivan recognizes Toscana Biomarkers with the 2008 European Frost & Sullivan Excellence in Research Award. The company demonstrated that the incorporation of synthetically modified peptides for the validation and discovery of biomarkers aids effective diagnosis of autoimmune diseases and is also looking to adopt robust methods to identify novel diagnostic solutions.

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Biomarkers have been used extensively in the genetic and molecular analysis of complications such as autoimmune diseases. Toscana Biomarkers focuses on identifying specific biomarkers detectable in patients' serum samples and validating the same with respect to the disease progression and activity.

"Antigenic peptides that can selectively and specifically recognise autoantibodies can be used in immunoenzymatic assays to detect disease biomarkers," says Frost & Sullivan Research Analyst Suraj Ramanathan. "Therefore, the company aims to develop robust biomarkers panel for the diagnosis of autoimmune diseases ranging from rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) to more complex diseases such as multiple sclerosis (MS) and systemic sclerosis."

To complement its focus on the manufacture of novel disease biomarkers, Toscana Biomarkers is working on developing in-vitro diagnostic assays, especially the enzyme-linked immuno sorbent assay (ELISA) for autoimmune diseases.

The company's R&D revolves around a peptide-based reverse approach [chemical reverse approach (CRA)], which indicates that the screening of antigenic probes is primarily guided by the antibodies circulating in a patient's biological fluids. The circulating auto-a
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