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Frost & Sullivan Lauds OVATION Pharmaceuticals for Its Business Model and Ability to Sustain Growth
Date:3/4/2009

"Many of OVATION's compounds acquired through partner company divestitures or out-license agreements are currently available and being successfully marketed, both locally and globally, or are in the late-stages of clinical trials for approval in the U.S.," says Hughes. "In fact, numerous drugs in OVATION's marketed product portfolio count themselves among the only in the world to effectively treat a broad spectrum of diseases in underserved markets."

Most recently, the company's November 2008 launch of Xenazine, the product of a licensing agreement with Prestwick Pharmaceuticals, a wholly owned subsidiary of Biovail Corp., marked the approval of the first-and-only medication available in the U.S. approved specifically for treating chorea associated with Huntington's disease (HD), a rare neurodegenerative disease affecting fewer than 25,000 Americans.

From OVATION's prolific late-stage CNS development pipeline, three new compounds addressing unmet medical needs are projected to launch over the next two years. Leading the way is Sabril(R) (vigabatrin), a GABA-transaminase inhibitor that is effective in reducing epileptic seizures. The company received unanimous positive recommendations for approval from FDA Advisory Committees in January 2009 on two New Drug Applications (NDAs) for Sabril(R); as adjunctive therapy for adults with refractory Complex Partial Seizures (CPS) and as monotherapy for infants with Infantile Spasms (IS). As there are currently no approved therapies for IS, a devastating form of epilepsy accounting for two percent of all childhood epilepsies, the IS NDA was granted priority review by the FDA. OVATION anticipates that the launch of Sabril(R) for both indications could occur as early as spring 2009.

Further expanding upon Sabril's(R) utility, OVATION, in collaboration with the National Institute on Drug Abuse, is evaluating the safety and efficacy of Sabril(R) in a phase II trial for
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SOURCE Frost & Sullivan
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