Navigation Links
Frontal cortex dysfunction may contribute to compulsive sexual behavior
Date:6/10/2010

Philadelphia, PA, 10 June, 2010 - Sex "addiction" is a concept that has had particularly high visibility recently with the publicity associated with Tiger Woods. Persons with addictive or compulsive disorders frequently display an inability to inhibit behaviors once they become maladaptive, despite adverse consequences of their behavior. The medial prefrontal cortex (mPFC) is a brain region involved in decision-making and behavioral flexibility, and it has been identified as a potential mediator of behavioral inhibition.

In a new study, Dr. Lique Coolen and colleagues tested whether the mPFC is involved in inhibition of sexual behavior when associated with aversive outcomes. Using a carefully-designed experimental paradigm in rats, the researchers found that lesions of the mPFC result in compulsive sexual behavior. In contrast, lesions did not alter sexual performance or the learning associated with reward or aversive stimuli. This indicates that intact mPFC function is not required for normal expression of sexual behavior.

Instead, the results support the hypothesis that the mPFC regulates the execution of behavioral inhibition toward sexual behavior once this behavior is associated with aversive outcomes. The animals with mPFC lesions were likely capable of forming the associations with aversive outcomes of their behavior but lacked the ability to suppress seeking of sexual reward in the face of aversive consequences.

Collectively, these data suggest a general role for the mPFC in regulating the compulsive seeking of reward, and may contribute to a better understanding of a common pathology underlying impulse control disorders.

Compulsive sexual behavior has a high prevalence of co-morbidity with psychiatric disorders, including substance abuse and mood disorders. The current study suggests that mPFC dysfunction may contribute to sexual risk-taking or to compulsive seeking of sexual behavior. Although thought-provoking, we do not yet know whether these findings apply to humans.


'/>"/>

Contact: Maureen Hunter
m.hunter@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related medicine news :

1. Self-Image Linked to Activity in Frontal Lobe of Brain
2. Link established between erectile dysfunction and calcified coronary arteries
3. Pitt researchers discover gene mutation linked to lymphatic dysfunction
4. Skin Condition Vitiligo Tied to Immune System Dysfunction
5. Language dysfunction in children may be due to epileptic brain activity
6. Real Men Don't Take Erectile Dysfunction Drugs Without a Prescription
7. Erectile Dysfunction Plus Heart Disease Raises Death Risk
8. Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction
9. Home Care Delivered, Inc. Launches a New Vacuum Therapy Category to Service Patients with Erectile Dysfunction
10. Erectile Dysfunction Predicts Heart Disease
11. Study links restless leg syndrome with erectile dysfunction in older men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... Virginia Washington, DC (PRWEB) , ... ... ... Media Contact: Claudia Tellez, Executive Director 703.462.0658, ctellez(at)msnva.org , The Medical Society ... for community physicians and their patients , The Medical Society of Northern ...
(Date:5/5/2016)... ... , ... Linfield College Online and Continuing Education is encouraging registered nurses to ... fee for all qualified applicants from May 1–14. Students need only go to the ... . , With the RN to BSN degree program, all core ...
(Date:5/5/2016)... FL (PRWEB) , ... May 05, 2016 , ... In ... is easy to forget the most important arrangement — planning a safe way of ... celebrations and popular tequila drinks. Unfortunately, these celebrations often lead to drunk drivers on ...
(Date:5/5/2016)... ... May 05, 2016 , ... Is the part in your ... just a few days away, it’s a good opportunity to raise awareness about a ... American Academy of Dermatology, 40% of women experience hair loss or ‘thinning’ by the ...
(Date:5/5/2016)... ... May 05, 2016 , ... BloodHub, the nation’s ... service orders. Blood suppliers and their hospitals use BloodHub for order management, ... active users across 2,100 hospitals who use our platform to processes thousands of ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)...  Compass Diversified Holdings (NYSE: CODI ) ... leading middle market businesses, announced today its consolidated operating ... First Quarter 2016 Highlights , Generated ... "Cash Flow") of $13.6 million for the first quarter ... million for the first quarter of 2016; , ...
(Date:5/4/2016)... May 4, 2016 Yissum ... announced today that it had signed an exclusive ... , developer of novel protein degradation and immunomodulatory drugs ... commercialization of drug candidates representing first-in-class therapy for hematologic ... not disclosed. The novel technology was developed ...
(Date:5/4/2016)... May 4, 2016 ... the  "Global Acute Myeloid Leukemia Market and ... their offering.       (Logo: ... Leukemia Market and Competitive Landscape Highlights 2016, ... pipeline products, Acute Myeloid Leukemia epidemiology, Acute ...
Breaking Medicine Technology: