Navigation Links
From mother to daughters: A central mystery in cell division solved
Date:12/9/2008

Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have identified a key step required for cell division in a study that could help improve therapies to treat cancer. Their work describing the mechanism of the contractile ring a structure that pinches the mother cell into two daughter cells has been published in the December 5 issue of the journal Science.

The division of one cell into two is accomplished by the contractile ring, which is assembled from two protein filament types, actin and myosin, that are also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle.

As happens during muscle contraction, the myosin filaments move along the actin filaments and constrict the ring. Constriction "tightens the belt," pinching the mother cell into two daughter cells.

"Normally, the contractile ring is built from long, straight actin filaments, which serve as tracks on which myosin filaments move along to drive constriction," said Karen Oegema, Ph.D, assistant professor at the Ludwig Institute and the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine. "We discovered that a key step in ring constriction is turning off a pathway that would form branches on these long filaments, preventing them from being efficient tracks for myosin filament movement."

"This discovery will open the door to further studies of cell division that could improve chemotherapies for cancer," said first author Julie Canman, Ph.D., postdoctoral fellow in the areas of leukemia and lymphoma at UC San Diego and the Ludwig Institute. "Right now, drugs used in chemotherapy affect the division of all the body's cells, leading to adverse side effects,
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Houston Mother Who Nearly Lost Her Daughter to Influenza Joins American Lung Associations Faces of Influenza Campaign to Promote Annual Vaccination
2. Survey Shows Mothers See Value in Influenza Vaccination for Their Families Through the Winter and Spring
3. Sacramento Mother Dee Dee Abdur-Rahim and Deputy District Attorney Robin Shakely Join the American Lung Associations Faces of Influenza Campaign to Promote Annual Vaccination
4. Oncologists Rank Aloxis Marketing Message Most Influential in the Chemotherapy-Induced Nausea and Vomiting Drug Market
5. Mother of Five Wins $5,000 in Minnesota Quit-Smoking Contest
6. TomoTherapy Names Rafael Vaello Vice President of Global Sales : Former Philips Healthcare executive brings proven sales experience in oncology, imaging industries
7. Studies show novel device may enhance chemotherapy treatment in brain tumors
8. Iressa as Good as Chemotherapy for Lung Cancer
9. Chemotherapy plus targeted therapies shows improved survival in advance-stage lung cancer patients
10. Study improves recovery for mothers with depression
11. The Neuropathy Associations Scientific Research Grants Focus: Autoimmune and Chemotherapy-Induced Neuropathies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... school students seem to be satisfied with the healthier school ... of school officials. , , New meal standards -- issued ... in the fall of 2012. At the time, there was ... most of their food. But the new study of nearly ... , "The updated meals standards are resulting in healthier meals ...
(Date:7/28/2014)... 2014 Ticket Down is reliable ... in Dallas, TX at the Cotton Bowl. The 2014 ... USA and it is an eight team tourney. The ... including teams from La Liga, Serie A, English Premier League, ... it out on the pitch include: Manchester United, Manchester ...
(Date:7/28/2014)... 28, 2014 Shofner Vision Center ... June . Renowned LASIK and Cataract Surgeon, Dr. ... significant funds and public awareness for local not-for-profit ... personnel and their families. “This was our 2nd ... nearly $5,000 to a variety of local not-for-profit ...
(Date:7/28/2014)... Braintree, Massachusetts (PRWEB) July 28, 2014 ... the Summit Provider Exchange technology solution ... office integration efforts and support collaboration with their ... 242 bed acute-care medical center located in New ... 800,000 seasonal visitors with a variety of inpatient ...
(Date:7/28/2014)... HealthDay Reporter MONDAY, July ... are at risk of contracting meningitis because of specific ... to updated recommendations from the largest pediatrician group in ... the potentially deadly infection should continue for adolescents and ... In its first statement on meningococcal vaccines since 2011, ...
Breaking Medicine News(10 mins):Health News:Healthy School Lunches Get Thumbs Up From Students 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 3Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 3Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 2Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 3Health News:Doctors Urge Meningitis Shots for Vulnerable Infants, Children 2Health News:Doctors Urge Meningitis Shots for Vulnerable Infants, Children 3
... incidents at the nation’s hospitals rose three percent over ... hospitals had a 40 percent lower rate of medical ... the largest annual study of patient-safety issued today by ... ,The HealthGrades study of 40.56 million Medicare hospitalization ...
... figure out the words' meaning for themselves, research by a ... an undergraduate student in the John Hopkins University and who ... by inference is more powerful for 3-year-olds than just being ... that is particularly exciting about the work Meredith is doing ...
... A homeopathic treatment for cancer is under trial at a ... it would pass muster in the next six months., ... homeopathic medicine have already begun in the United States and ... its efficacy," Dr Susanta K Banerjee, a professor of haematology ...
... the state children’s health insurance program (SCHIP), teens ... eliminated and more preventive care is received. This ... their health care providers about guns, smoking, drugs, ... their long-term health. ,"Adolescents have the ...
... For the first time ever, a team of Toronto ... tests //to screen high-risk pregnant mothers for placental damage. ... be reassured that their placenta is formed and functioning ... tests are done early enough, at 16 to 23 ...
... endogenous pain-inhibitory function and increases spontaneous pain in women//. ... in chronic pain, according to a study published in ... ,The study, conducted by Michael T. Smith, PhD, and ... females, who were studied polysomnographically for seven nights. On ...
Cached Medicine News:Health News:Hospital Errors Rise 3 Percent -- HealthGrades Patient-safety Study 2Health News:Hospital Errors Rise 3 Percent -- HealthGrades Patient-safety Study 3Health News:Learning Words by Inference More Powerful for Toddlers 2Health News:Teens Get Needed Access to Care With State Health Insurance 2Health News:Teens Get Needed Access to Care With State Health Insurance 3Health News:New Placenta Screening for High-risk Pregnancies 2Health News:New Study in SLEEP Finds That Sleep Disturbance Increases Spontaneous Pain in Women 2
(Date:7/28/2014)... FRANCISCO, Calif. , July 28, 2014 ... provided an update on the status of the KB001-A ... with Sanofi Pasteur.  KB001-A Collaboration ... an agreement with Sanofi Pasteur to regain all rights ... and licensing agreement entered into in 2010 has been ...
(Date:7/28/2014)... July 28, 2014 Reportlinker.com announces that ... its catalogue: Portugal Pharmaceuticals and ... http://www.reportlinker.com/p0207141/Portugal-Pharmaceuticals-and-Healthcare-Report-Q3-2014.html Includes 3 ... Faster-than-expected economic growth last quarter has led us ... upwards. As forecast previously, BMI expects ...
(Date:7/28/2014)... 2014  Air Products (NYSE: APD ) ... is vital to any healthcare facility. This understanding has ... improve the efficiency of its oxygen supply systems, but ... systems—including systems for emergency oxygen supply and ... at the 51 st ASHE Annual Conference ...
Breaking Medicine Technology:KaloBios Provides Update on KB001-A Partnership and Clinical Status 2KaloBios Provides Update on KB001-A Partnership and Clinical Status 3KaloBios Provides Update on KB001-A Partnership and Clinical Status 4KaloBios Provides Update on KB001-A Partnership and Clinical Status 5KaloBios Provides Update on KB001-A Partnership and Clinical Status 6Portugal Pharmaceuticals and Healthcare Report Q3 2014 2Portugal Pharmaceuticals and Healthcare Report Q3 2014 3Portugal Pharmaceuticals and Healthcare Report Q3 2014 4Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: