Navigation Links
From mother to daughters: A central mystery in cell division solved
Date:12/9/2008

Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have identified a key step required for cell division in a study that could help improve therapies to treat cancer. Their work describing the mechanism of the contractile ring a structure that pinches the mother cell into two daughter cells has been published in the December 5 issue of the journal Science.

The division of one cell into two is accomplished by the contractile ring, which is assembled from two protein filament types, actin and myosin, that are also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle.

As happens during muscle contraction, the myosin filaments move along the actin filaments and constrict the ring. Constriction "tightens the belt," pinching the mother cell into two daughter cells.

"Normally, the contractile ring is built from long, straight actin filaments, which serve as tracks on which myosin filaments move along to drive constriction," said Karen Oegema, Ph.D, assistant professor at the Ludwig Institute and the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine. "We discovered that a key step in ring constriction is turning off a pathway that would form branches on these long filaments, preventing them from being efficient tracks for myosin filament movement."

"This discovery will open the door to further studies of cell division that could improve chemotherapies for cancer," said first author Julie Canman, Ph.D., postdoctoral fellow in the areas of leukemia and lymphoma at UC San Diego and the Ludwig Institute. "Right now, drugs used in chemotherapy affect the division of all the body's cells, leading to adverse side effects, like sterility and death of the white blood cells that are essential for immunity," said Canman. "If we could specifically target the dividing cancer cells, we could improve on current chemotherapy to treat cancer with fewer side effects, allowing patients to continue therapy with a higher quality of life."


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Houston Mother Who Nearly Lost Her Daughter to Influenza Joins American Lung Associations Faces of Influenza Campaign to Promote Annual Vaccination
2. Survey Shows Mothers See Value in Influenza Vaccination for Their Families Through the Winter and Spring
3. Sacramento Mother Dee Dee Abdur-Rahim and Deputy District Attorney Robin Shakely Join the American Lung Associations Faces of Influenza Campaign to Promote Annual Vaccination
4. Oncologists Rank Aloxis Marketing Message Most Influential in the Chemotherapy-Induced Nausea and Vomiting Drug Market
5. Mother of Five Wins $5,000 in Minnesota Quit-Smoking Contest
6. TomoTherapy Names Rafael Vaello Vice President of Global Sales : Former Philips Healthcare executive brings proven sales experience in oncology, imaging industries
7. Studies show novel device may enhance chemotherapy treatment in brain tumors
8. Iressa as Good as Chemotherapy for Lung Cancer
9. Chemotherapy plus targeted therapies shows improved survival in advance-stage lung cancer patients
10. Study improves recovery for mothers with depression
11. The Neuropathy Associations Scientific Research Grants Focus: Autoimmune and Chemotherapy-Induced Neuropathies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2017)... ... 28, 2017 , ... Starting in May, patients at The Bay Clinic ... (HRV) diagnostic test. , Nerve-Express, originally designed for the Navy in the 1980s, measures ... a patient’s autonomic nervous system (ANS). The ANS controls all the critical unconscious ...
(Date:5/28/2017)... ... May 28, 2017 , ... Florida ... to announce that Sheldon K. Cho, MD, has joined its Winter Haven practice. ... that concentrates on minimally invasive techniques to treat and manage many types of ...
(Date:5/27/2017)... ... ... visiting the dentist? You should go twice per year for checkups, but if you want ... Here are some dental tips to help out: , 1. Brushing Teeth - Brush your ... or a locker at school for a quick brushing after lunch. Use a small brush ...
(Date:5/27/2017)... CA (PRWEB) , ... May 27, 2017 , ... Most ... for concern, but a new study from the Osteoarthritis Initiative shows that ... developing knee osteoarthritis. Knowing this in advance may give doctors the opportunity to treat ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... Boston CEO 2017 on May 30th and 31st at The Four Seasons Hotel ... leading executives in the life sciences, offering exclusive access to key decision makers ...
Breaking Medicine News(10 mins):
(Date:5/23/2017)... PLEASANTON, Calif. , May 23, 2017 /PRNewswire/ ... world,s most innovative medical devices for pressure ulcer ... at the American Association of Critical Care Nurses, ... Houston May 22-25. The Leaf Patient ... designed specifically for the hospital environment.  The system ...
(Date:5/15/2017)... , May 15, 2017  Amy Baxter MD, ... industry leader in noninvasive pain relief, was awarded a ... magazine. Baxter was recognized at the MM&M Top ... New York City on May 10, 2017. ... the biopharma industry go "beyond the pill."  ...
(Date:5/10/2017)... Global Health Intelligence (GHI), the leading healthcare data analytics ... 2017 ranking of the Best-Equipped Hospitals in Latin America ... GHI,s hospitals database for Latin America , which is ... database covers 86% of the hospitals in Latin ... each institution in key areas such as beds, medical specialties, ...
Breaking Medicine Technology: