Navigation Links
From mother to daughters: A central mystery in cell division solved
Date:12/9/2008

Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have identified a key step required for cell division in a study that could help improve therapies to treat cancer. Their work describing the mechanism of the contractile ring a structure that pinches the mother cell into two daughter cells has been published in the December 5 issue of the journal Science.

The division of one cell into two is accomplished by the contractile ring, which is assembled from two protein filament types, actin and myosin, that are also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle.

As happens during muscle contraction, the myosin filaments move along the actin filaments and constrict the ring. Constriction "tightens the belt," pinching the mother cell into two daughter cells.

"Normally, the contractile ring is built from long, straight actin filaments, which serve as tracks on which myosin filaments move along to drive constriction," said Karen Oegema, Ph.D, assistant professor at the Ludwig Institute and the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine. "We discovered that a key step in ring constriction is turning off a pathway that would form branches on these long filaments, preventing them from being efficient tracks for myosin filament movement."

"This discovery will open the door to further studies of cell division that could improve chemotherapies for cancer," said first author Julie Canman, Ph.D., postdoctoral fellow in the areas of leukemia and lymphoma at UC San Diego and the Ludwig Institute. "Right now, drugs used in chemotherapy affect the division of all the body's cells, leading to adverse side effects,
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Houston Mother Who Nearly Lost Her Daughter to Influenza Joins American Lung Associations Faces of Influenza Campaign to Promote Annual Vaccination
2. Survey Shows Mothers See Value in Influenza Vaccination for Their Families Through the Winter and Spring
3. Sacramento Mother Dee Dee Abdur-Rahim and Deputy District Attorney Robin Shakely Join the American Lung Associations Faces of Influenza Campaign to Promote Annual Vaccination
4. Oncologists Rank Aloxis Marketing Message Most Influential in the Chemotherapy-Induced Nausea and Vomiting Drug Market
5. Mother of Five Wins $5,000 in Minnesota Quit-Smoking Contest
6. TomoTherapy Names Rafael Vaello Vice President of Global Sales : Former Philips Healthcare executive brings proven sales experience in oncology, imaging industries
7. Studies show novel device may enhance chemotherapy treatment in brain tumors
8. Iressa as Good as Chemotherapy for Lung Cancer
9. Chemotherapy plus targeted therapies shows improved survival in advance-stage lung cancer patients
10. Study improves recovery for mothers with depression
11. The Neuropathy Associations Scientific Research Grants Focus: Autoimmune and Chemotherapy-Induced Neuropathies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... 25, 2013 Radius Engineering International ... company in the US and has been building ... over 35 years. M.E. and President, Walton McCarthy, ... NBC Weapon Fundamentals and Shelter Engineering Standards, Sixth ... on shelter engineering. McCarthy is considered the leading ...
(Date:5/25/2013)... 25, 2013 Studies from Johns Hopkins ... carrying excessive weight and their inability to get adequate ... losing weight can naturally relieve many symptoms. , ... in sleep quality was significantly associated with overall weight ... study dated November 6th, 2012, researchers monitored 77 ...
(Date:5/25/2013)... 2013 Providing patients with their best weight ... of weight management professionals. But, aside from educating patients on ... Doc’s hCG diets also provide patients, who have ... like bullying, more control over their lives by achieving their ... the underlying factors of weight gain derived from earlier abuse, ...
(Date:5/25/2013)... (PRWEB) May 25, 2013 Absolute Surgical Specialists, ... many of the NALA’s businesses throughout the country participating in ... to participate in the nationwide event as he understands what ... Colonel in the Army. He said, “I wanted to give ... I serve, but I live here too.” , Shop Local ...
(Date:5/25/2013)... May 25, 2013 On May 20, 2013 ... do not wish to discuss or plan for their eventual ... FuneralFinancials.com released a Must-Do List to help people ... Financials recommends, “Creating a personal fact sheet.” , While not ... financial information and personal data. It may include a ...
Breaking Medicine News(10 mins):Health News:Radius Engineering International Inc. Offers Tools to Stay Safe and Recover From Any Disaster 2Health News:Radius Engineering International Inc. Offers Tools to Stay Safe and Recover From Any Disaster 3Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Newly Improved hCG Diet Plans Capable of Delivering Better Sleep 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 3Health News:Dr. Craig Amshel of Absolute Surgical Specialists Offering Bowel Prep During the Shop Local for a Cause Event 2Health News:FuneralFinancials.com Releases Last Wishes Must-Do List 2
... 2006 issue of the Journal of Adolescent Health by researchers// ... Miriam Hospital and Brown Medical School, suggests that as teens ... and increase their fast food consumption - both behaviors leads ... the transition from adolescence to adulthood appears to be a ...
... poultry farm in south western Japan in Kiyotake, around 750 ... ,This has been reported to the agricultural ministry ... out latest by Friday evening. If bird flu is confirmed, ... ,The farm in question has around 12000 ...
... to toddlers, parents need to be cautious as it may bring ... ,The Centre for Disease Control and Prevention in the US has ... children suffering from cold or cough without consulting their doctor. ... the age group of six months in 2005 revealed that they ...
... whose health and normal life was affected by a parrot was ... of Derbyshire who used to work for a pet shop had ... were very much like ordinary fever. But subsequent diagnosis revealed that ... he did not have direct contact with the sick African Grey ...
... the students gathered for a live chat with Indian American ... as she spoke from her zero-gravity// home among the stars, ... fact they had only read about in books before. ... and speak with three astronauts at the same platform - ...
... of data has revealed that more number of Canadians are ... decade ago. The recovery time for patients after// surgery is ... study of hospitalization and surgery rates undertaken by the Canadian ... patients in the healthcare system. The report showed that the ...
Cached Medicine News:Health News:Skipping Breakfast and Fast Food Consumption - Leads to Weight Gain 2Health News:Skipping Breakfast and Fast Food Consumption - Leads to Weight Gain 3Health News:Indian Students Thrilled to Talk to Sunita Williams 2
(Date:5/24/2013)... CHAPEL HILL, N.C. , May 24, 2013 ... Affairs to the forefront of many organizations, priority ... biopharmaceutical and medical device sectors understand a strong ... meeting current challenges in clinical development, market ... operate effectively to create a vital bridge between ...
(Date:5/24/2013)... N.J. , May 24, 2013  BD (Becton, Dickinson ... medical technology company, announced today that it will present at ... on Thursday, May 30, 2013, at 10:40 a.m. (ET). ... accessed from the BD corporate website at www.bd.com/investors ... 2013.    About BD BD is ...
(Date:5/24/2013)... /PRNewswire-iReach/ -- Phoenix Houses of California ... is hosting its tenth annual "Triumph For Teens" Awards ... 2013.  More than 300 people are expected to attend ... treatment centers, family therapy, and prevention programs of Phoenix ... positive influences on the health and welfare of our community ...
Breaking Medicine Technology:Building Medical Affairs Capabilities to Ensure Organizational Success across Key Operational Areas 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 3
... ATLANTA and IRVINE, Calif., April 18, 2011 CryoLife, ... medical device and cardiovascular tissue processing company, today announced ... part of its definitive agreement with Cardiogenesis Corporation ("Cardiogenesis"), ... 49.9 percent of the outstanding shares of Cardiogenesis. ...
... Benvenue Medical, Inc., a developer of minimally invasive solutions for ... C round of financing.  The proceeds will be used to ... A ugmentation Treatment – A S afety and Effectiveness ...  Benvenue Medical is entering a $9 billion global spinal device ...
Cached Medicine Technology:CryoLife Announces Expiration of Go-Shop Period Related to its Proposed Acquisition of Cardiogenesis Corporation 2CryoLife Announces Expiration of Go-Shop Period Related to its Proposed Acquisition of Cardiogenesis Corporation 3CryoLife Announces Expiration of Go-Shop Period Related to its Proposed Acquisition of Cardiogenesis Corporation 4CryoLife Announces Expiration of Go-Shop Period Related to its Proposed Acquisition of Cardiogenesis Corporation 5CryoLife Announces Expiration of Go-Shop Period Related to its Proposed Acquisition of Cardiogenesis Corporation 6CryoLife Announces Expiration of Go-Shop Period Related to its Proposed Acquisition of Cardiogenesis Corporation 7Benvenue Medical Closes $35.5 Million Series C Financing 2Benvenue Medical Closes $35.5 Million Series C Financing 3
Bougie Urethrotomes for slitting the female urethra and for meatus stenosis in males...
... The USA Elite System™ ... Urethrotomes are utilized for ... and bladder neck contractures ... visual obturator converts the ...
... Cystoscope with Slide-On EndoSheath Technology from ... efficient solution for Urologists in both ... Unlike conventional flexible cystoscopes, which require ... CST-2000 eliminates the need to reprocess ...
... Video Cystoscope from Olympus is a giant ... proprietary video chip technology with an industry-leading ... a flexible video cystoscope with an image ... rod lens system. As a result, this ...
Medicine Products: