Navigation Links
From mother to daughters: A central mystery in cell division solved
Date:12/9/2008

Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have identified a key step required for cell division in a study that could help improve therapies to treat cancer. Their work describing the mechanism of the contractile ring a structure that pinches the mother cell into two daughter cells has been published in the December 5 issue of the journal Science.

The division of one cell into two is accomplished by the contractile ring, which is assembled from two protein filament types, actin and myosin, that are also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle.

As happens during muscle contraction, the myosin filaments move along the actin filaments and constrict the ring. Constriction "tightens the belt," pinching the mother cell into two daughter cells.

"Normally, the contractile ring is built from long, straight actin filaments, which serve as tracks on which myosin filaments move along to drive constriction," said Karen Oegema, Ph.D, assistant professor at the Ludwig Institute and the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine. "We discovered that a key step in ring constriction is turning off a pathway that would form branches on these long filaments, preventing them from being efficient tracks for myosin filament movement."

"This discovery will open the door to further studies of cell division that could improve chemotherapies for cancer," said first author Julie Canman, Ph.D., postdoctoral fellow in the areas of leukemia and lymphoma at UC San Diego and the Ludwig Institute. "Right now, drugs used in chemotherapy affect the division of all the body's cells, leading to adverse side effects,
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Houston Mother Who Nearly Lost Her Daughter to Influenza Joins American Lung Associations Faces of Influenza Campaign to Promote Annual Vaccination
2. Survey Shows Mothers See Value in Influenza Vaccination for Their Families Through the Winter and Spring
3. Sacramento Mother Dee Dee Abdur-Rahim and Deputy District Attorney Robin Shakely Join the American Lung Associations Faces of Influenza Campaign to Promote Annual Vaccination
4. Oncologists Rank Aloxis Marketing Message Most Influential in the Chemotherapy-Induced Nausea and Vomiting Drug Market
5. Mother of Five Wins $5,000 in Minnesota Quit-Smoking Contest
6. TomoTherapy Names Rafael Vaello Vice President of Global Sales : Former Philips Healthcare executive brings proven sales experience in oncology, imaging industries
7. Studies show novel device may enhance chemotherapy treatment in brain tumors
8. Iressa as Good as Chemotherapy for Lung Cancer
9. Chemotherapy plus targeted therapies shows improved survival in advance-stage lung cancer patients
10. Study improves recovery for mothers with depression
11. The Neuropathy Associations Scientific Research Grants Focus: Autoimmune and Chemotherapy-Induced Neuropathies

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2009)...AN FRANCISCO, Nov. 27 Th...that Blair Lambert, CFO/COO, will present at the N...d at the May Fair Hotel in London, England, on Wed... To listen to a live broadcast of The Gymboree Cor...log on to www.gymboree.com, click on "Our Company"...
(Date:11/27/2009)..., NEUILLY-SUR-SEINE, France, Nov. 27 /PRNewswire/ ...essional cycling team dedicated to ethical sportin...ampions, announced today that it will become Team ...s Optical as a new sponsor of the team. Transition...daptive eyewear, offering the most advanced photoc...
(Date:11/27/2009)... XenaCare Holdings has announced that... Foundation, one of the largest nonprofit organiza...ealth education. , Delray...oldings, Inc. (OTCBB: XCHO), a company specializin...umer healthcare products, has announced today that...
(Date:11/27/2009)...s to bring unprecedented medical, economic burdens...althDay News) -- The number of people with diabete...the next 25 years, a new study predicts. , That...on people with the disease, up from 23.7 million t... people with diabetes will triple, the study also ...
(Date:11/27/2009)... Voyant Health™ announced today... licensed its TraumaCad Enterprise orthopedic temp...solution. , (PRWEB) Novem...ay that Spectrum Health (Grand Rapids, Michigan) h...mplating solution and its TraumaCad Extend workflo...
Breaking Medicine News(10 mins):Health News:Team Garmin-Slipstream Officially Re-named Team Garmin-Transitions With Addition of Transitions Optical as New Sponsor 2Health News:Team Garmin-Slipstream Officially Re-named Team Garmin-Transitions With Addition of Transitions Optical as New Sponsor 3Health News:XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation 2Health News:XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation 3Health News:XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation 4Health News:Diabetes Cases Expected to Double in 25 Years 2Health News:Diabetes Cases Expected to Double in 25 Years 3Health News:Voyant Health Announces: Spectrum Health Licenses TraumaCad Enterprise and TraumaCad Extend 2Health News:Voyant Health Announces: Spectrum Health Licenses TraumaCad Enterprise and TraumaCad Extend 3
...ON, Sept. 28 - About a third of American,adults ta...n nearly every,case, the goal is better health, ev...s hope. The absence of benefit is one thing, but t...sk among,men using multivitamins, reports the Octo...
...anies, Church Team Up to Transport Goods to Peru, ... today,teamed up with its largest customer, DHL, t...goods provided by The Church of Jesus Christ of La...ds of,specially processed, ultra-high temperature ...
...URHAM, N.C. -- Determining the genetic profile of ...he crucial decision about which chemotherapy treat...rs from the Duke University Comprehensive Cancer C... chemotherapy drugs. , We were able to predict w...
...IEL, Israel, Sept. 28 The Russell,Investment Grou... ) that,there will be a float weight adjustment ef..., 2007 in the following indexes: Russell 2000,Russ...e Russell Small Cap Completeness Growth. About Pr...
...ement of William V. Corr Executive Director, Campa... Kids, WASHINGTON, Sept. 28 The following is ...or, Campaign for,Tobacco-Free Kids: Last night, t...ax to help fund the State Children,s Health Insura...
...ROSS, Ga., Sept. 28 Immucor, Inc.,(Nasdaq: BLUD ...nt-reagent,systems to the blood transfusion indust... first quarter earnings on Wednesday, October 3, 2...vestors,are invited to participate in this confere...
Other Medicine News:Health News:Excessive Multivitamin Use May Raise Risk for Prostate Cancer, from Harvard Men's Health Watch 2Health News:ASTAR Air Cargo, The Church of Jesus Christ of Latter-day Saints and DHL to Help Peruvian Earthquake Victims 2Health News:ASTAR Air Cargo, The Church of Jesus Christ of Latter-day Saints and DHL to Help Peruvian Earthquake Victims 3Health News:Genomic profiling of lung tumors helps doctors choose most effective treatment 2Health News:Genomic profiling of lung tumors helps doctors choose most effective treatment 3Health News:Russell Investment Group Advises Protalix Biotherapeutics of Index Adjustment 2Health News:President Bush Should Protect Kids, Not Big Tobacco By Signing Bill to Increase Cigarette Tax, Fund SCHIP 2Health News:Immucor Schedules First Quarter Earnings Release and Conference Call 2
(Date:11/25/2009)..., Nov. 25 From November 16-18, Ph...ng solutions, presented the second edition of the ...e special needs of the older population. The confe...d audiology from around the world and more than 25...ith hearing loss for an opportunity to share exper...
(Date:11/25/2009)...5 AMPAC Fine Chemicals LLC (AFC), ...aq: APFC ) announced today that it received the E...rd at the Annual Statewide Environmental Summit, s...ology Association (CMTA), the Industrial Environme...ouncil of California (CICC) held in San Diego. Th...
(Date:11/25/2009)...Newswire-FirstCall/ -- Abaxis, Inc. (Nasdaq: ABAX...-of-care blood analysis systems, announced today t...fficer, will present at the 21st Annual Piper Jaff...2, 2009 at 2:00 p.m. ET. The conference will be he...,, About Abaxis ,, Abaxis develops, manuf...
Breaking Medicine Technology:Phonak Successfully Hosts Hearing Care for Adults 2009 Conference 2Phonak Successfully Hosts Hearing Care for Adults 2009 Conference 3AMPAC Fine Chemicals Receives Prestigious Award at California's Annual Statewide Environmental Summit 2AMPAC Fine Chemicals Receives Prestigious Award at California's Annual Statewide Environmental Summit 3Rotary Declares World Polio Day 59667 1Dartmouth Medical School Faculty Member and Anesthesiologist Invents Revolutionary Catheter System Designed to Increase Rate of Successful IV Insertio 5541 1Dartmouth Medical School Faculty Member and Anesthesiologist Invents Revolutionary Catheter System Designed to Increase Rate of Successful IV Insertio 5541 2Dartmouth Medical School Faculty Member and Anesthesiologist Invents Revolutionary Catheter System Designed to Increase Rate of Successful IV Insertio 5541 3ESC press statement 3A Cigarettes on sale on the internet 59661 1ESC press statement 3A Cigarettes on sale on the internet 59661 2ESC press statement 3A Cigarettes on sale on the internet 59661 3
...N, Pa., March 9 Isolagen, Inc. (Amex: ILE ) tod...logics License Application (BLA) for Isolagen Ther...for the treatment of wrinkles/nasolabial folds, to...Company,s wrinkles/nasolabial folds Phase III tria...sessment. , , "This BLA submission is a significa...
...DIEGO, March 9 Cardium Therapeutics (NYSE Alterne...pies, Inc., today reported that positive clinical ...continence using localized manual cooling techniqu...urgery will be published in the April 2009 issue o.../www.goldjournal.net/article/S0090-4295(08)01953-5...
Other Medicine Technology:Isolagen, Inc. Submits Biologics License Application for the Treatment of Wrinkles to the U.S. Food and Drug Administration 2Isolagen, Inc. Submits Biologics License Application for the Treatment of Wrinkles to the U.S. Food and Drug Administration 3Isolagen, Inc. Submits Biologics License Application for the Treatment of Wrinkles to the U.S. Food and Drug Administration 4Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology 2Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology 3Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology 4Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology 5Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology 6Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology 7Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology 8
OEC UroView 2800
Hydra Vision® Plus DR Urology System
...ect® Heavy Duty is a pressure relief mattress ...rapy specifically to the BariKare® Bed., ,IND...d 650 lbs., Large patients at risk or suffering fr...ic mattress that would benefit from a pressure rel...
...00 is a bariatric bed system which helps provide c... setting, ,INDICATIONS: ,Patients weighing up to ...ame accommodating one or two individuals, dependin...tal weight in excess of 1000 lbs. (including acces...
Medicine Products: