Navigation Links
From blank round to a potently active substance?
Date:4/19/2013

differing mechanism of action

Prof. Hornung believed that the lack of transferability between mice and humans might be associated with the specific target structures that CMA latches on to. The team working with Prof. Hornung was then able to identify the protein to which CMA attaches, its receptor, in mouse cells. However, the human counterpart of this receptor did not respond to CMA. When CMA binds to the receptor in mice, a signal cascade is set into motion that leads to the release of interferons which in turn boost the immune system. However, in order for this to work, CMA and its receptor must fit together like a lock and key. Together with the laboratory of Prof. Dr. Karl-Peter Hopfner from the Gene Center at the Ludwig Maximilian University in Munich, the team from the Bonn University Hospital investigated the receptor variants of mice and humans in cell cultures and as purified proteins.

Animal models cannot easily be transferred to humans

"A few small differences in the receptor make the active substance completely ineffective in humans," reports lead author Taner Cavlar, postgraduate in Prof. Hornung's team. In humans, this prevents CMA from being able to latch its crucial receptor and release interferon, even though immune stimulation occurs in mice. "This is an example of the fact that results from animal models cannot always be easily transferred to humans," says Prof. Hornung. "Comparative investigations on human cells should take place at an early stage of active substance development."

Findings inspire the search for an antiviral drug

Since the scientists were able to figure out the exact structure of the mouse and human receptors, they now have an approach to see if there are conditions under which CMA could also arm the human immune system to fight viruses. This is now the next step which the researchers want to address with their colleagues. However, it will likely take many years u
'/>"/>

Contact: Dr. Veit Hornung
veit.hornung@uni-bonn.de
49-228-287-51200
University of Bonn
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Snowstorms Blanketing the US Causing Major Outbreaks of Dry Skin, Columbia Healing Cream Reveals the Solution
2. Give the Gift of Allergy Free Blankets from Allergy Asthma Technology this Holiday Season
3. Groundbreaking study to transform service users involvement in mental health care
4. Breast Augmentation – Do Women Prefer Round or Shaped Implants?
5. Desert Cancer Foundation Gala Offers a Round For Life by Brad Schmett
6. University of Maine Football Completes Ground-Breaking Team Leadership and Emotional Intelligence Training Program
7. Roundworm Infections Threaten Organ Recipients
8. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Introduces New Diet Plans Built Around an Eating Schedule to Produce the Best Weight Loss with Little Effort
9. Jose Cirino, Director of Operations for GeneCell International, Accentuates the Importance Surrounding the Minority Community
10. Texas physician breaks ground in robotic cervical surgery
11. Shopping Around Brings Steep Prescription Drug Savings, Report Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... FL (PRWEB) August 27, 2014 The ... September 5th, 6th and 7th at the Florida State ... Festival celebrates all Latino art and cultures from around ... present their platinum sponsor Go Smart Mobile and Univision ... Action Festival is expecting an estimate of 4,000 people ...
(Date:8/27/2014)... Dennis Thompson HealthDay Reporter ... who has been mugged in a dark alley will likely ... a fear of being attacked. But neuroscientists working with ... memories are linked with positive and negative emotions. And in ... attached to a memory. In essence, they made once-reluctant ...
(Date:8/27/2014)... 28, 2014 BRIC Laparoscopes Market Outlook ... provides key market data on the BRIC Laparoscopes market. ... volume (in units) and average prices (in US dollars) ... and Flexible Tip Video Laparoscopes), Robotic Surgical Systems and ... of advantages to the patient with laparoscopic surgery versus ...
(Date:8/27/2014)... Dr. Stewart Shofner and Dr. Kevin ... suffering from impaired vision. Some of the most common ... . Recently, Dr. Shofner has noticed a significant increase ... and also online. To help patients understand the facts, ... , 1)    Myth: People with perfect vision won’t develop glaucoma. ...
(Date:8/27/2014)... August 27, 2014 The extensive ... nurses by healthcare research group Black Book Rankings ... not adequately staffed, supplied or built to care ... Book initiated this annual survey to gain stakeholder ... infection control, epidemiology and emergency preparedness systems,” said ...
Breaking Medicine News(10 mins):Health News:Marc Anthony to Perform at "Nieves Productions" Latinos in Action Festival 2Health News:Scientists 'Rewrite' Bad Memories in Mice 2Health News:Scientists 'Rewrite' Bad Memories in Mice 3Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 2Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 3Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 4Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 2Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 3Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 4Health News:American Hospitals Are Vastly Unprepared for Ebola Patients, Reveals Black Book™ Survey of Emergency Physicians, Nurses and Infection Control Practitioners 2Health News:American Hospitals Are Vastly Unprepared for Ebola Patients, Reveals Black Book™ Survey of Emergency Physicians, Nurses and Infection Control Practitioners 3Health News:American Hospitals Are Vastly Unprepared for Ebola Patients, Reveals Black Book™ Survey of Emergency Physicians, Nurses and Infection Control Practitioners 4
... ... in technology will have a bottom-line impact on people’s health. While ... is a new breed of technology aimed at preventative, integrative health solutions. ... tracking tools, providing members ways to track, understand, and improve their health ...
... , Jan. 19 The National Theatre for Children ... with the only global entertainment brand dedicated to kids health, ... healthy exercise to the kids and families who need it most. ... will tour a curriculum-based and interactive live show – performed by ...
... Birth Defect Research Reveals Craniofacial & Brain ... CELEBRATION, Fla. , Jan. 19 Nearly two-thirds of ... Birth Defect Registry (NBDR) also suffer from structural birth defects, ... . The group reported that most of the defects affect the ...
... acids in the solution reduce inflammation, researchers note , ... to intravenous solutions proved beneficial for intensive care patients ... a new study finds. , The study, published Jan. ... 13 patients who received fish oil in the normal ...
... ... Screening and Treatment , ... Heights, NJ (Vocus) January 19, 2010 -- During Glaucoma Awareness Month, Summit Medical Group wants ... the eyes that causes vision loss. Because there often are no symptoms in its early ...
... ... satisfied with their health insurers, according to a study released today by ... employers of all sizes are taking a critical look at their health ... looking to their health plan providers for information, technology and strategies to ...
Cached Medicine News:Health News:Online Tools to Transform the Way People Manage Their Health 2Health News:Online Tools to Transform the Way People Manage Their Health 3Health News:World's #1 Health Brand for Kids Joins Forces With World's #1 In-School Children's Theatre 2Health News:World's #1 Health Brand for Kids Joins Forces With World's #1 In-School Children's Theatre 3Health News:World's #1 Health Brand for Kids Joins Forces With World's #1 In-School Children's Theatre 4Health News:High Rates of Birth Defects Found in Autistic Children 2Health News:Adding Fish Oil to IV May Speed Sepsis Recovery 2Health News:January is Glaucoma Awareness Month 2Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 2Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 3Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 4Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 5Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 6Health News:Employer Satisfaction with Health Insurers is Declining, Finds PricewaterhouseCoopers Study 7
(Date:8/27/2014)... Ambit Biosciences (Nasdaq: AMBI ), a biopharmaceutical ... needs in oncology, autoimmune and inflammatory disease, today announced the ... be held at The New York Palace Hotel in ... Alan Fuhrman , Ambit,s CFO, will provide ... quizartinib, at 1:10 p.m. ET on Wednesday, September 3, 2014.  ...
(Date:8/27/2014)... Aug. 27, 2014  After the February 2014 launch ... billing solution for medical practices and management companies, ... the new software. "The feedback has been ... . "The sheer number of demos and new sign-ups ... was for these types of software features." ...
(Date:8/27/2014)... WARSAW, Ind. , Aug. 27, 2014  Zimmer ... in musculoskeletal care, announced that it will be participating ... the Grand Hyatt in New York, New ... David Dvorak , President and CEO of Zimmer, will ... Binder , President and CEO of Biomet, will join ...
Breaking Medicine Technology:Ambit Announces Participation At Baird 2014 Health Care Conference 2Medical Software Company, Prime Clinical Systems, Sees Excellent Response to their Workers' Compensation Solutions 2Medical Software Company, Prime Clinical Systems, Sees Excellent Response to their Workers' Compensation Solutions 3
... UPPSALA, Sweden, January 13 Beactica AB, the ... research,collaboration agreement with GE Healthcare (Chalfont St. Giles, ... tools, and Uppsala,University (Sweden). The collaboration ... GE Healthcare,s Biacore(TM) technology with,enzymology expertise from ...
... Life League,s historic Personhood Conference is featuring ... cell research and regenerative medicine.(Logo: ... CEO of AVM Biotechnology and President of ... over 17 years of experience in scientific ...
Cached Medicine Technology:Beactica Announces Fragment-Based Drug Discovery Research Collaboration With GE Healthcare and Uppsala University 2Stem Cell Pioneer to Speak to A.L.L. Personhood Conference 2
... head design has been carefully considered with both ... head ensures the optimum viewing angle and the ... laser aligned for perfect focus where it is ... paper. This along with Keeler's wide angle ...
The Beta 200S combines Heine's patented aspherical optics (U.S. Pat. 4.963.014) and a single-step Rekoss disk with a range of 36 to +38 dpt. to provide perfectly-focused images even in cases of high ...
... 200S is the first hand-held ... of patented aspherical optics (U.S. ... of corrective lenses from 36 ... diopter steps. A perfectly-focused image ...
... The ophthalmoscope with superior aspherical optics. ... illumination and observation beam by means of ... iris reflex (Gullstrand-principle). The Beta 200 allows ... illuminated section of the retina even with ...
Medicine Products: