Navigation Links
From blank round to a potently active substance?
Date:4/19/2013

differing mechanism of action

Prof. Hornung believed that the lack of transferability between mice and humans might be associated with the specific target structures that CMA latches on to. The team working with Prof. Hornung was then able to identify the protein to which CMA attaches, its receptor, in mouse cells. However, the human counterpart of this receptor did not respond to CMA. When CMA binds to the receptor in mice, a signal cascade is set into motion that leads to the release of interferons which in turn boost the immune system. However, in order for this to work, CMA and its receptor must fit together like a lock and key. Together with the laboratory of Prof. Dr. Karl-Peter Hopfner from the Gene Center at the Ludwig Maximilian University in Munich, the team from the Bonn University Hospital investigated the receptor variants of mice and humans in cell cultures and as purified proteins.

Animal models cannot easily be transferred to humans

"A few small differences in the receptor make the active substance completely ineffective in humans," reports lead author Taner Cavlar, postgraduate in Prof. Hornung's team. In humans, this prevents CMA from being able to latch its crucial receptor and release interferon, even though immune stimulation occurs in mice. "This is an example of the fact that results from animal models cannot always be easily transferred to humans," says Prof. Hornung. "Comparative investigations on human cells should take place at an early stage of active substance development."

Findings inspire the search for an antiviral drug

Since the scientists were able to figure out the exact structure of the mouse and human receptors, they now have an approach to see if there are conditions under which CMA could also arm the human immune system to fight viruses. This is now the next step which the researchers want to address with their colleagues. However, it will likely take many years u
'/>"/>

Contact: Dr. Veit Hornung
veit.hornung@uni-bonn.de
49-228-287-51200
University of Bonn
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Snowstorms Blanketing the US Causing Major Outbreaks of Dry Skin, Columbia Healing Cream Reveals the Solution
2. Give the Gift of Allergy Free Blankets from Allergy Asthma Technology this Holiday Season
3. Groundbreaking study to transform service users involvement in mental health care
4. Breast Augmentation – Do Women Prefer Round or Shaped Implants?
5. Desert Cancer Foundation Gala Offers a Round For Life by Brad Schmett
6. University of Maine Football Completes Ground-Breaking Team Leadership and Emotional Intelligence Training Program
7. Roundworm Infections Threaten Organ Recipients
8. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Introduces New Diet Plans Built Around an Eating Schedule to Produce the Best Weight Loss with Little Effort
9. Jose Cirino, Director of Operations for GeneCell International, Accentuates the Importance Surrounding the Minority Community
10. Texas physician breaks ground in robotic cervical surgery
11. Shopping Around Brings Steep Prescription Drug Savings, Report Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... San Diego, California (PRWEB) May 29, 2015 ... Common Core” and have joined the national effort to teach ... Many parents in the U.S. have been “sickened” by the ... country. However, love it or hate it, Common Core is ... the District of Columbia. Parents are now seeking ways ...
(Date:5/29/2015)... May 29, 2015 The print component ... a circulation of approximately 250,000 and an estimated readership ... a vast social media strategy, and across a network ... the digital version of the campaign, click here. ... print publication. Inside, the actress, model and producer details ...
(Date:5/29/2015)... Ill (PRWEB) May 29, 2015 OncLive ... , a dozen medical pioneers recognized by a panel ... the course of cancer treatment. Honorees will be introduced ... Cancer Care™ Award Ceremony, held 8:30-11:00 p.m. CDT at ... The 2015 honorees are being recognized for groundbreaking accomplishments, ...
(Date:5/29/2015)... Oaksterdam University, the first cannabis college in America, will return to ... highly demanded Basic and Advanced Classic Seminars on ... pm each day. Certification is available upon completion of the seminars ... June 14 from 12:00 pm to 6:00 pm. Both the seminars ... & Casino in downtown Las Vegas. , Seminar topics ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 Designed with ... teamed up to create an all new, exclusive line ... a formulated with the latest and greatest, high impact, ... proven to be effective. The 24/7 Series can be ... cross-fitters and even the casual fitness enthusiasts. There are ...
Breaking Medicine News(10 mins):Health News:Doctors Discover a Cure for the Common Core 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 3Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 4Health News:Oaksterdam University to Host Educational Cannabis Seminars and Job Fair in Las Vegas June 12 to 15; Training For Those Wanting To Work in Legal Cannabis Industry 2Health News:Oaksterdam University to Host Educational Cannabis Seminars and Job Fair in Las Vegas June 12 to 15; Training For Those Wanting To Work in Legal Cannabis Industry 3Health News:BPI Sports and Bodybuilding.com Partner Up to Bring an Innovative New Line of Supplements 2Health News:BPI Sports and Bodybuilding.com Partner Up to Bring an Innovative New Line of Supplements 3
... ... ROI , ... NY and Piscataway NJ (PRWEB) June 4, 2010 -- UniteU Technologies, Inc., a leading ... solutions for online stores, are announcing the availability of Filtered Navigation Search Express (FNS ...
... first time, scientists have discovered a possible biological culprit ... type of estrogen called estradiol. The groundbreaking pilot ... of one,s genes on eating disorder symptoms was much ... than pubertal girls with lower levels of estradiol. The ...
... researchers say , FRIDAY, June 4 (HealthDay News) ... Wii Sports -- may help overweight seniors become more ... Although not an improvement on real-life gaming and sports ... offer a good alternative for those older individuals for ...
... ... recently selected to receive the AAOMS (American Association of Oral & Maxillofacial Surgeons) Humanitarian Award ... ... been selected to receive the AAOMS (American Association of Oral & Maxillofacial Surgeons) Humanitarian Award ...
... ... virtualisation software SoftXpand, as the exclusive distributor for supplying its award-winning multi-user solution to ... ... been appointed by Miniframe, supplier of innovative desktop virtualisation software SoftXpand, as the exclusive ...
... ... full, four year accreditation by the Board of Vocational Nursing and Psychiatric Technicians (BVNPT). ... Modesto, CA ... that its Modesto and Fresno Campuses, Vocational Nursing Programs have been recently awarded a ...
Cached Medicine News:Health News:UniteU and Celebros Launch Dynamic Cross-Sell and New Version of Filtered Navigation Search 2Health News:UniteU and Celebros Launch Dynamic Cross-Sell and New Version of Filtered Navigation Search 3Health News:MSU researchers discover potential genetic factor in eating disorders 2Health News:Wii Games Can Get Seniors Moving 2Health News:Dr. Randolph C. Robinson Recently Awarded AAOMS (American Association of Oral & Maxillofacial Surgeons) Humanitarian Award 2Health News:Dr. Randolph C. Robinson Recently Awarded AAOMS (American Association of Oral & Maxillofacial Surgeons) Humanitarian Award 3Health News:London Web Expands Green IT with SoftXpand Desktop Virtualisation Solution 2Health News:London Web Expands Green IT with SoftXpand Desktop Virtualisation Solution 3
(Date:5/28/2015)... -- IRIDEX Corporation (NASDAQ: IRIX ) today announced that Chief ... is scheduled to present at the LD Micro Invitational ... Los Angeles . A live ... Event Calendar of the Investors section of IRIDEX,s website at ... available shortly after the conclusion of the presentation and will ...
(Date:5/28/2015)... NEW YORK , May 28, 2015 /PRNewswire/ ... morcellators ( http://www.morcellatorlawsuit2015.com )  in hysterectomies and myomectomies (procedures ... report indicates that the FBI is investigating Johnson ... the largest manufacturer of the devices. According to ... on May 27 th , the FBI is ...
(Date:5/28/2015)... , May 28, 2015 ... announced the addition of the "United States ... report to their offering.      (Logo: ... adhesives in the United States ... 2020 Medical device manufacturers across ...
Breaking Medicine Technology:Power Morcellator Attorneys at Bernstein Liebhard LLP Comment on Report That FBI Is Investigating Ethicon Morcellators 2Power Morcellator Attorneys at Bernstein Liebhard LLP Comment on Report That FBI Is Investigating Ethicon Morcellators 3United States Medical Adhesives Market Forecast and Opportunities, 2020 - New Medical Innovations with 3M, Henkel Adhesive Research, Ethicon and Cyberbond Dominating 2United States Medical Adhesives Market Forecast and Opportunities, 2020 - New Medical Innovations with 3M, Henkel Adhesive Research, Ethicon and Cyberbond Dominating 3
... VALLEY, Pa., Dec. 14, 2011 /PRNewswire-iReach/ -- ... by introducing a collection of EZ Shot 2 single-use ... needles offer excellent puncture capability along with an adjustable ... targeted site. Available in a complete selection of sizes ...
... 14, 2011  The National Association of Drug ... that facilitates cooperation between law enforcement, healthcare ... in the prevention and investigation of drug ... National Precursor Log Exchange (NPLEx) in Indiana ...
Cached Medicine Technology:Olympus Broadens Portfolio With a Suite of New Single-Use Aspiration Needles 2Indiana Stop-Sale System Shows Effectiveness of Real-Time, Blocking Technology in the Fight Against Illegal Sales of Pseudoephedrine 2
Optipress II Automated Blood Component Extractor for the standardized separation of whole blood into high purity individual components...
... Stepper, a lightweight, easy-to-use repeater ... up to 45 times in ... Stepper handle is adapted for ... a dispensing volume range from ...
... The Repeater Plus, a handheld manual dispenser, ... time on long series pipetting. Its increased ... support for research tasks, and its smooth ... repetitive work. The nine Combitips allow a ...
... of its kind, the noncontact EnSite ... cardiac electrical information, translating it into ... electrodes, this unique tool simplifies ablation ... points of electrical data in a ...
Medicine Products: