Navigation Links
From a Failed Vaccine, New Insights Into Fighting HIV
Date:4/4/2012

By Randy Dotinga
HealthDay Reporter

WEDNESDAY, April 4 (HealthDay News) -- A new study offers insight into why an HIV vaccine failed to protect most people who received it, but it also points to promising new targets for future vaccine efforts.

Scientists believe an HIV vaccine, designed to prevent infection with the virus that causes AIDS, is still several years away. Tests of experimental vaccines have largely been failures so far.

Nevertheless, the prospect of a vaccine remains tantalizing because it could make a major dent in the spread of HIV and AIDS around the world.

The new research "gives us a handle on how the immune system deals with the virus and is affected by a vaccine," said study lead author Dr. Barton Haynes, director at the Duke Human Vaccine Institute at Duke University in Durham, N.C. "It gives us clues and a firm direction to look into."

The study is based on work by more than 100 scientists from 25 institutions, and appears in the April 5 issue of the New England Journal of Medicine.

Haynes and his colleagues examined the results of a 2009 study of an HIV vaccine in Thailand. In a trial involving more than 16,000 people, the vaccine appeared to cut the risk of infection by only 31 percent. That was still considered a major advance over previous vaccines that didn't work at all, Haynes noted.

The vaccine, called RV144, wasn't ready for prime time because it didn't protect enough people, Haynes said. "You want to get it above 50 percent," he said, and some scientists believe the rate should be even higher than that.

Despite the vaccine's failure, the authors of the new study were able to use the data to learn more about how the immune system deals with HIV and how the vaccine changes the "big picture" of the body's response to the virus.

The new research is an "exhaustive molecular analysis," said Dr. Lindsey Baden, an associate professor of medicine in the infectious disease division at Brigham and Women's Hospital in Boston who co-wrote a commentary accompanying the study.

Haynes said one surprising finding is about an antibody -- a soldier of the immune system -- that helps protect against influenza infection. Ironically, the antibody appears to boost the likelihood of HIV infection, he said.

Another finding was that higher levels of antibodies that home in on a particular region of HIV's outer shell, called V1V2, were associated with lower rates of infection with the virus.

This and other information in the study may help researchers come up with theories about where to go next with vaccine development, Baden said. Among other things, it can reveal parts of the immune system that can be most useful in battling the transmission of HIV.

Vaccines are available to fight other kinds of viruses, such as measles and influenza. HIV is unique, however, because it inserts its genetic material into the body's cells.

"When a person gets infected with HIV, that genetic material goes underground," Haynes said. "It's invisible to the body's immune system."

Another challenge is that the virus mutates, becoming a moving target.

"It changes so rapidly in the person who gets infected that even when the immune system does try to control it, in most people the immune system is always playing catch up," Haynes said.

More information

There's more on HIV/AIDS at the U.S. National Library of Medicine.

SOURCES: Barton Haynes, M.D., director, Duke Human Vaccine Institute, Duke University, Durham, N.C.; and Lindsey Baden, M.D., infectious physician, Brigham and Women's Hospital, Boston. April 5, 2012, The New England Journal of Medicine.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cancer Society Says U.S. Report Failed to Prove Health Risks
2. PCBs Might Be Linked to Failed IVF Attempts
3. Katrinas Aftermath: Failed Pregnancies for IVF Moms Nationwide
4. Hallmark Insights Completes SAS 70 Type II Audit
5. Employers Voice Opinions on Health Care Plans, Gain Insights on Health Care Reform
6. Happy Feet Clinic Now Open in Buffalo Grove, IL; Starting A Business in Impossible Times: Valuable Insights and Experiences
7. Rwandan genocide survivors provide new insights into resilience and PTSD
8. Carefx Delivers Expert Insights on Health Data Sharing, Collaboration, Quality and Meaningful Use
9. ADD Insights, LLC and The New England ADHD Treatment Center Announce a Joint Seminar Series: Mastering One's ADHD
10. Media Alert: Model N and International Medical Device Leader to Share Insights on Maximizing Sales Performance with Revenue Management
11. New Insights Into Whos At Risk With Angioplasty
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
From a Failed Vaccine, New Insights Into Fighting HIV
(Date:9/20/2017)... ... September 20, 2017 , ... Mirror Mirror Beauty Boutique ... Look Awesome This Autumn with CoolSculpting®. Scheduled for Thursday, September 28th, the afternoon ... Mirror Mirror Beauty Boutique is Houston’s largest CoolSculpting provider, holding the ...
(Date:9/20/2017)... ... 20, 2017 , ... Announced that Clear Global ... services market) has entered into an agreement on September 1, 2017 with The ... is the first private Dental School to launch an online, accredited Post Graduate ...
(Date:9/20/2017)... ... September 20, 2017 , ... Compliancy Group ... compliance software, The Guard®, has helped another long-time client pass their Department of ... properly satisfy the law. , Thanks to the help of the Compliancy Group's ...
(Date:9/20/2017)... ... ... In just a short time since going on sale on Wal-Mart Stores-owned ... trying the product for the first time, and others who had already been using ... Moore, MD, for everyone from athletes at risk from multiple concussions to elderly consumers ...
(Date:9/20/2017)... ... September 20, 2017 , ... Five consumer packaged goods (CPG) products were selected ... different categories. Nopavera Plus was named to the short list in the ... West 2017 during presentations at SupplySide Central on Sept. 27 and 28 at Mandalay ...
Breaking Medicine News(10 mins):
(Date:9/1/2017)... Michael Penna , President and CEO ... for growth in his response to the July 13, ... seeking a buyer for eMDs. Penna,s company, Complete HealthCare ... Value Added Reseller and national leader in the independent ... "As the healthcare market continues to dictate consolidation, healthcare ...
(Date:8/29/2017)... ivWatch, LLC, the leading provider of continuous monitoring devices for the ... an Innovative Technology contract from Vizient, Inc., the largest member-driven health ... ... detection of peripheral IV infiltration and extravasation events ... The Innovative Technology contract was awarded to ivWatch based on ...
(Date:8/25/2017)... 2017  Innovation Zed ( www.innovationzed.com ), an Irish medtech company, today ... South Yorkshire and Bassetlaw, England . ... diabetes patients as part of a national NHS Test Bed programme exploring ... Innovation Zed ... InsulCheck Connect, a snap-on accessory for disposable insulin pen users, ...
Breaking Medicine Technology: