Navigation Links
Frequent inaccuracies in testosterone testing lead to call for standardization
Date:10/8/2010

Chevy Chase, MDThe use of testosterone assays for patient care and research is on the rise as new research links testosterone to a variety of diseases and conditions. Although the assays are heavily used, discrepancies and inaccuracies in measurements resulting from the various assays are widespread. Seeking to address this critical health issue, a multidisciplinary group of experts convened by The Endocrine Society and the US Centers for Disease Control and Prevention just issued recommendations for improving and standardizing testosterone testing in a consensus statement to be published in the October 2010 issue of The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Testosterone assays are tests that measure testosterone levels which, in turn, are used to diagnose and treat patients with a number of disorders. These disorders may include: testicular or pituitary diseases in men potentially leading to erectile dysfunction and decreased sexual drive; polycystic ovarian syndrome which may cause menstrual disturbances and infertility in women; and early or late pubertal development in children.

"The development of this consensus statement has been a collaborative effort among key stakeholders including professional societies, laboratories and regulatory agencies," said William Rosner, MD, a lead author of the consensus statement and a member of The Endocrine Society. "Not only does this entire group benefit from better assays, but all bear some responsibility in working to improve accuracy."

Aimed at improving the quality of research, patient care and public health through broad implementation of standardized testosterone measurements that are accurate, reliable and comparable over time, the consensus statement recommends the following:

  • All stakeholders should acknowledge the importance of testosterone assay standardization and work closely with the CDC to formulate plans to implement accuracy-based, calibrated testing across the community of assay providers and users;
  • The expert scientific and medical communities should work to:

    • define performance criteria that cover the full range of expected values, from children to adult males and females;
    • define reference intervals for testosterone in adults and children of both sexes; and
    • develop guidelines and protocols to ensure uniform patient preparation and handling of samples before they are assayed.

  • Third-party payers and health care organizations should promote the use of and enable payment for assays that have been standardized through the above mentioned efforts;
  • Funding entities, journals and others involved in research should support the standardization of assays; and
  • Manufacturers and laboratories should continue to develop new methodological approaches ensuring the sensitive, specific, accurate and cost-effective measurement of testosterone.

"The recommendations in this consensus statement emphasize the need for the research, medical and industry communities to each play their part in improving testosterone assays," said Rosner. "High quality testosterone testing will not only provide for better patient care outcomes but will rein in the cost of health care as they will lessen the need for frequent retesting."

The consensus statement has been endorsed by the following organizations:

  • American Association for Clinical Chemistry
  • American Association of Clinical Endocrinologists
  • Androgen Excess/PCOS Society
  • American Society for Bone and Mineral Research
  • American Society for Reproductive Medicine
  • American Urological Association
  • Association of Public Health Laboratories
  • The Endocrine Society
  • Laboratory Corporation of America
  • North American Menopause Society
  • Pediatric Endocrine Society (formerly known as Lawson Wilkins Pediatric Endocrine Society)

The Coalition for Quality Testing, comprising most of the groups listed above and other interested organizations, has been formed to address the technical aspects of reference intervals and performance criteria; to develop guidelines and protocols; and to educate third-party payers, funding entities, journals and other relevant stakeholders.

The statement, "Toward Excellence in Testosterone Testing; A Consensus Statement," will appear in the October 2010 issue of JCEM.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. News brief: Benefit of HPV Vaccination, Frequent Screening for Women over 41 is Likely to be Low
2. MSU researcher links potentially deadly infection, frequent cow exposure
3. Do men with early prostate cancer commit suicide more frequently?
4. The most frequent error in medicine
5. Immigrants with disabilities more frequently employed than US-born persons with disabilities
6. Evidence-based medicine theory can be applied to frequent flying says US professor
7. Botox reduces wrinkles even in less frequent doses
8. Frequent Doctor Visits Help Diabetics Control Blood Pressure
9. Frequent Urination at Night Linked to Raised Death Risk
10. Anxiety/panic disorder most frequent disabling comorbid disorder in TS patients, study finds
11. Adverse childhood experiences linked to frequent headache in adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... cutting edge technology to revolutionize the emergency ambulance transport experience for the millions ... aware of how Uber has disrupted the taxi industry through the use of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology and specialty ... Bracket eCOA (SM) 6.0, at the 52 nd ... in Philadelphia , Pennsylvania.  A demonstration of ... its kind to fully integrate with RTSM, will be held ... a flexible platform for electronic clinical outcomes assessments that is ...
Breaking Medicine Technology: