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Frequent Urination at Night Linked to Raised Death Risk
Date:5/30/2010

Study found correlation was strongest for those under 65

SUNDAY, May 30 (HealthDay News) -- People who wake up frequently during the night to urinate are at an increased risk of death even after accounting for chronic conditions that are known to cause the problem, two new studies show.

The findings, scheduled to be presented Sunday at the American Urological Association's annual meeting in San Francisco, suggest that frequent urination at night, or nocturia, is a predictor of mortality in adults of all ages rather than just the elderly, and that other unrecognized medical conditions may be contributing factors.

In the first study, researchers at the New England Research Institutes in Watertown, Mass., examined the health records of nearly 16,000 men and women aged 20 and older, and found that those who woke up to urinate two or more times a night had a higher risk of mortality than those who made less than two nighttime bathroom trips. The association between nocturia and mortality remained even after adjusting for coexisting conditions, such as diabetes and cardiovascular disease, and was stronger in those aged 20 to 64 than it was in those aged 65 and older.

"In the younger age group, those who reported having nocturia had roughly twice the risk of mortality as those without, while in the older age group nocturia increased the risk in the range of 20 to 30 percent," said study author Varant Kupelian, a research assistant at the New England Research Institutes.

Kupelian and colleagues examined records from the Third National Health and Nutrition Examination Survey (NHANES III) conducted between 1988 and 1994, as well as death certificate data in the National Death Index through Dec. 31, 2000. In the study group of 15,988 men and women, the prevalence of nocturia was 15.5 percent among men and roughly 21 percent among women, and increased rapidly with age.

Kupelian said the greater risk of mort
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