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Frequency of alcohol consumption and cardiovascular risk factors
Date:11/20/2012

g). Further, most previous research, including many basic science interventions and limited trials in humans, have shown that the administration (intake) of moderate amounts of an alcoholic beverage leads to more favourable cardiovascular risk factors, and numerous mechanisms have been identified (higher HDL-cholesterol, improved vascular reactivity, improved platelet and other coagulation factors, etc.).

The authors of this paper take an unusual turn when it comes to discussing the implications of their results. They tend to down-play any potential health benefits that may be caused by alcohol or the pattern of drinking and infer instead that the favourable risk factors themselves may lead to the drinking pattern. Forum members disagreed with the implications of the authors on a number of factors: (1) the lack of randomized trials of low-dose alcohol consumption; (2) levels of evidence; (3) drinking frequency and alcohol intake; (4) clustering of lifestyle behaviours; (5) alcohol consumption and CVD-related biomarkers; (6) alcohol intake, cancer and total mortality. Further, Forum reviewers cite a large body of scientific research that refutes some of the conclusions of the authors, which imply that regular moderate alcohol intake does not relate to improved cardiovascular risk factors.

Forum reviewers agree with a concluding statement of the authors about using caution before recommending drinking to the general public. However, they believe that the arguments presented in this paper are not based on a balanced appraisal of available scientific data, and should not be used to support changes in guidelines for the public.


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Contact: R Curtis Ellison
ellison@bu.edu
Boston University Medical Center
Source:Eurekalert

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